1. INTRODUCTION OF PELLETS AND
PALLETIZATION PROCESS
Presented by :-
Pralhad D. Shinde
(B.pharma 7th sem)
Roll No. 67
guided by:-
Prof. Mr. V. S. Padghan
M. Pharm (Pharmaceutics)
Shradha Institute of Pharmacy, Kondala Zamre, Washim
Pin :-444402
2023-24
2. Pellets And Pelletization Process
Defination
Size
Advantages and disadvantage
Excipients used in pellets
Pelletization techniques
References
1.
• Objectives • Slide no.
• 2
• 2
• 3
• 4
• 5
• 13
3. Pellets
What are the pellets?
. Multiple unit dosage form
. Small, free flowing, and spherical
Manufactured by agglomeration process
. Size – 0.5-1.5 mm
2.
4. Advantages and disadvantage of
pellets
Advantages
Uniformity of dose
Good flow property
Easy to handle
Prevention of dust formation
Controlled release
Better drug formation
3.
• Disadvantage
• Cost
• Tableting
• Tough
• Equipments
6. Production of Pellets
Drug layering
A) Powder layering
B) Solution/Suspension layering
Extrusion spherionization
Cryopelletization
Compression
Balling
Hot melt extrusion
5.
7. (1) Drug layering
A) Powder layering
It is most widely and easy method which is used in formation of pellets.
Powdered drug and excipients or both preformed to form cores with the aid
of binding liquid.
Both are added simulataneously in a controlled manner.
6.
Fig - 1
9. 2) Extrusion Spherionization
This is the machinery based technique in which drug
solution and Binder solution mixed together and by
compression they are converted into small pellets.
They are smooth and small size pellets.
They are very spherical in nature.
8.
10. 3) Cryopelletization
A process in wgich droplets of liquid formulation are converted in solid
spherical particles or pellets by using liquid nitrogen as the fixing medium.
9.
Fig. - 3
11. 4) Compression
In this method, binder solution and drug solution are mixed
together and form large lumps.
With the help of compression technique, the pressure is
applied and forms small granules or they are converted into
small pellets.
10.
12. 5) Balling
In this technique, binder solution and drug solution binds
together with the help of large machine by the equipments
and converted into the ball form.
11.
13. 6) Hot Melt extrusion
In this technique, the Binder solution is melt at high
temperature.
It is same as bolling process.
In this method, pellets are obtained in the form of balls.
12.
14. References
1. Liberman, Lachman & J. B. Schwartz, Pharmaceutical Dosage Forms -
Tablets, Volume 1-3, P. No.
2. Liberman & Lachman Pharmaceutical Dosage Forms- Parenteral
Medication, Volume- 1& 2, P. No.
https://youtu.be/XAqXaJNL_m0
google.co.in
13.
