2. Definition:
Wound is a discontinuity or break in the surface epithelium.
A wound is simple when only skin is involved.
It is complex when it involves underlying nerves, vessels and
tendons.
6. HEALING OF WOUND:
Healing by primary intention:occurs in clean incised
surgical wound.
Healing by secondary intention: refers a wound which
is infected,discharging pus or wound with skin loss.
8. INFLAMMATORY PHASE
Injury results in the release of inflammatory mediators
mainly histamines from platelets,mast cells and
graunlocytes.
This results in increased capillary permiability.
Later kinins and prostaglandins play a chemotactic role
for white cells and fibroblast.
In 48 hours PMN leucocytes dominate.That leucocyte
play the role of scavengers by removing dead and
necrotic tissue.
9. PROLIFERATIVE PHASE:
Between 3RD And 5TH Days,PMN leucocytes
Monocytes increase (specialised scavenger)
By 5th or 6 th day ,fibroblast appear,proliferate and give rise to
protocollagen which is converted in to collagen.
protocollagen
in presence of protocollagen hydroxylase,o2 ,ferrous
ion and ascorbic aacid.
collagen
10. Epithelialisation : occurs mainly from the edges of the
wound by a process of cell migration and cell
umltiplication.
This is mainly brought about by marginal basal cell.
Thus within first 48 hour entire wound is reepithelised.
11. Remodelling phase:
Starts after 4 days and completed within 14 days
Brought about by specialised fibroblast they are called
myofibroblast because of their contractile nature.
It is the natures way of reducing the size of defect,helping
in wound healing.
Connective tissue formation:formation of granulation is the
most important process in wound healing.
12. Phase of scar formation:
Following changes take place during scar formation:
Collagen is increased
Vascularity becomes less
Epithelialisation continues
Ingrowth of lymphatics and nerve fibres takes place
Reodelling of collagen takes place with
cicatrisation,resulting in scar.
14. General principles of management of open wounds:
WOUND
CLEANING AND
BANDAGE
SPLINT IF THERE IS
FRACTURE
SUTURING TRANSPORT
ACTIVE BLEEDING
STOP THE BLEEDING
IV
LINE,RESUSCITATION
15. Admission and observation in hospital
Monitoring of TPR ,BP
Systemic antibiotic
Injection TT
Treatment in the form of cleaning ,dressing,or
suturing.
Wound closure :by primary suturing and secondary
suturing
16. Factors affecting wound Healing:
Age
Vit c deficiency
Diabetic patient
Jaundiced and uraemic patients
Cytotoxic drugs
Generelised infection and local infection
Corticosteroids
Malnutrition
Poor blood supply
Hypoxia ,ionising radiation
Faulty techniques of wound closure