Prabhakar Singh- IV_SEM-DISORDER OF LIPIDS

1. TEJASVI NAVADHITAMASTU
“Let our (the teacher and the taught) learning be radiant”
Let our efforts at learning be luminous and filled with joy, and endowed with the force of purpose
Paper XII: CLINICAL AND DIAGNOSTIC BIOCHEMISTRY
Dr. Prabhakar Singh. D.Phil. Biochemistry
Department of Biochemistry, VBSPU, Jaunpur
DISORDER OF LIPIDS

2. LIPOPROTEINS
A lipoprotein basically
consists of a neutral lipid
core (with triacylglycerol
and/or cholesterylester)
surrounded by a coat shell of
phospholipids, apoproteins
and cholesterol. The polar
portions (amphiphilic) of
phospholipids and
cholesterol are exposed on
the surface of lipoproteins
so that lipoprotein is soluble
in aqueous solution.
Lipoproteins are molecular complexes of lipids with proteins. They are the transport
vehicles for lipids in the circulation. There are five types of lipoproteins, namely
chylomicrons, very low density lipoproteins (VLDL), low density lipoproteins (LDL),
high density lipoproteins (HDL) and free fatty acid albumin complexes.
A general structure of lipoprotein complex. (Note : For the sake of
clarity, only a part of the shell and core are filled with the constituents)

3. CLASSIFICATION OF LIPOPROTEINS

5. METABOLISM OF LIPOPROTEINS LCAT
LCAT is a plasma enzyme, synthesized by the liver. It
catalyses the transfer of fatty acid from the second
position of phosphatidyl choline (lecithin) to the
hydroxyl group of cholesterol.
HDL-cholesterol is the real substrate for LCAT and this
reaction is freely reversible. LCAT activity is associated
with apo-A1 of HDL.
The cholesterol (cholesteryl) ester forms an integral part
of HDL. In this manner, the cholesterol from the
peripheral tissues is trapped in HDL, by a reaction
catalysed by LCAT and then transported to liver for
degradation and excretion. This mechanism is
commonly known as reverse cholesterol transport
High density lipoproteins (HDL) and the enzyme
lecithin-cholesterol acyltransferase (LCAT)are
responsible for the transport and elimination of
cholesterol from the body.

6. DISORDERS OF PLASMA LIPOPROTEINS

9. Disorder Of Sphingomyelins Metabolism
DISORDER OF GLYCOLIPIDS METABOLISM
Disorder Of Cerebrosides Metabolism

12. CHOLESTEROL

13. HYPERCHOLESTEROLEMIA

14. CONTROL OF
HYPERCHOLESTEROLEMIA

15. FATTY LIVER

17. KETONE BODIES

19. DISORDER OF KETONE BODIES