Urolithin A has been demonstrated to stimulate mitophagy and improve muscle health in old animals and in preclinical models of aging. Meanwhile, it also has been shown to cross the blood brain barrier, and may have neuroprotective effects against Alzheimer’s Disease. https://www.phcoker.com/product/urolithin-a/ info@phcoker.com

1. Xuchang shangke Chemical Co., Ltd
Phcoker www.phcoker.com
Email: info@phcoker.com
1
Supplements Urolithin A Reviews: Definition, Mechanism,
Benefits & Side Effects
What is Urolithin A?
Urolithin A is a metabolite compound resulting from the transformation of
ellagitannins by the gut bacteria. It belongs to the class of organic compounds known
as benzo-coumarins or dibenzo-α-pyrones. Urolithin A has been demonstrated to
stimulate mitophagy and improve muscle health in old animals and in preclinical
models of aging. Meanwhile, it also has been shown to cross the blood brain barrier,
and may have neuroprotective effects against Alzheimer’s Disease.
Urolithin A powder is a natural product with antiproliferative and antioxidant activity.
Urolithin A is formed by metabolism from polyphenols found in some nuts and fruits,
particularly pomegranates. Its precursors – ellagic acids and ellagitannins – are
ubiquitous in nature, including edible plants, such as pomegranates, strawberries,
raspberries, walnuts, tea and muscat grapes, as well as many tropical fruits.
Since the 2000s, urolithin A has been subject of preliminary studies regarding its
possible biological effects.
Urolithin A（1143-70-0）Specifications

2. Xuchang shangke Chemical Co., Ltd
Phcoker www.phcoker.com
Email: info@phcoker.com
2
How does Urolithin A work?
Urolithin A is urolithin, a microbial human metabolite of dietary ellagic acid
derivatives (such as ellagic acid). In the intestinal metabolism of bacteria, ellagitannin
and ellagic acid lead to the formation Active urolithins A, B, C and D. Among them,
urolithin A (UA) is the most active and effective intestinal metabolite, which can be
used as an effective anti-inflammatory and antioxidant.
In laboratory studies, it has been shown that urolithin A induces mitochondria, which
is the selective recovery of mitochondria through autophagy. Autophagy is a process
of removing defective mitochondria after injury or stress, and is efficient during aging.
lower and lower. This effect has been observed in different animal species

3. Xuchang shangke Chemical Co., Ltd
Phcoker www.phcoker.com
Email: info@phcoker.com
3
(mammalian cells, rodents and Caenorhabditis elegans).
However, because the source of ellagitannin is different, the composition of each
bacterial group will also be different, so the efficiency of conversion to urolithin A is
very different in humans, and some people may not have any conversion.
Urolithin A benefits
Urolithin A (UA) is a natural diet, a metabolite derived from the microbial community.
It has a variety of health benefits, including reducing inflammatory signaling,
anti-cancer effects and inhibiting lipid accumulation.
As the most active and effective intestinal metabolite, urolithin A (UA) can act as an
effective anti-inflammatory and antioxidant. It can also stimulate mitochondrial
phagocytosis in older animals and preclinical models of aging and improve muscle
health.
Can the Urolithin A be used as supplements?
In 2018, the US Food and Drug Administration classified urolithin A as a safe
ingredient in food or dietary supplement products, with amounts ranging from 250
milligrams to 1 gram per serving.
Is there any side effects of Urolithin A?
Safety studies in older adults have shown that urolithin A is well tolerated. In vivo
studies have not determined whether there are any toxicity or specific adverse effects

4. Xuchang shangke Chemical Co., Ltd
Phcoker www.phcoker.com
Email: info@phcoker.com
4
of dietary urolitin A intake.
Also, long-term safety for supplementation of Urolithin A and pomegranate is not
known, though short-term treatment with pomegranate extract is safe.
Reference:
[1] Garcia-Muñoz, Cristina; Vaillant, Fabrice (2014-12-02). “Metabolic Fate of
Ellagitannins: Implications for Health, and Research Perspectives for Innovative
Functional Foods”. Critical Reviews in Food Science and Nutrition. 54 (12): 1584–1598.
doi:10.1080/10408398.2011.644643. ISSN 1040-8398. PMID 24580560. S2CID
5387712.
[2] Ryu, D. et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans
and increases muscle function in rodents. Nat. Med. 22, 879–888 (2016).
[3] “FDA GRAS notice GRN No. 791: urolithin A”. US Food and Drug Administration. 20
December 2018. Retrieved 25 August 2020.
[4] Singh, A.; Andreux, P.; Blanco-Bose, W.; Ryu, D.; Aebischer, P.; Auwerx, J.; Rinsch, C.
(2017-07-01). “Orally administered urolithin A is safe and modulates muscle and
mitochondrial biomarkers in elderly”. Innovation in Aging. 1 (suppl_1): 1223–
[5] Heilman, Jacqueline; Andreux, Pénélope; Tran, Nga; Rinsch, Chris; Blanco-Bose,
William (2017). “Safety assessment of urolithin A, a metabolite produced by the
human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic
acid”. Food and Chemical Toxicology. 108 (Pt A): 289– doi:10.1016/j.fct.2017.07.050.
PMID 28757461.