Lithium orotate experience: What can you get from taking lithium orotate?

Xuchang Shangke Chemical Co., Ltd
Phcoker www.phcoker.com
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lithium orotate experience: What can you get from
taking lithium orotate?
Reproduce from:
https://www.phcoker.com/product/5266-20-6/
1. What is lithium orotate?.....................................................................................................................2
2. Is Lithium orotate dangerous?............................................................................................................2
3. Lithium orotate supplement- How does it work?.............................................................................. 3
4. Lithium orotate research- what does it do?.......................................................................................4
5. Lithoum orotate effects- What are the benefits of lithium orotate?.................................................4
6. Who can benefits from lithium orotate?..........................................................................................10
7. Lithium food sources?..................................................................................................................... 13
8. Lithium orotate half life - How long does lithium orotate take to work?........................................ 13
9. Lithium orotate experience: How to take lithium orotate?............................................................. 14
How much lithium orotate should I take?.................................................................................. 14
What is the best time to use lithium orotate supplements?......................................................14
How much lithium orotate should I take for depression?.......................................................... 15
How long will you have to take Lithium Orotate?.......................................................................15
10. Is it safe to use Lithium Orotate? Lithium orotate Side Effects and safety.................................... 16
11. The differences between lithium orotate and lithium...................................................................18
12. Lithium orotate vs lithium aspartate.............................................................................................18
13. FAQs of lithium orotate.................................................................................................................. 19

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1. What is lithium orotate?
Lithium Orotate is a compound that consists of orotic acid (a substance produced in
the body naturally) and an alkali metal commonly referred to as Lithium. Lithium is
an element available in the diet, mostly in vegetables and grains.
We have more lithium orotate sources as we will discuss later in this article. This is
why lithium orotate supplement is always known as “nutritional lithium.” Lithium
orotate is popular in the supplements market since it is regarded as a natural
treatment for a broad range of mental health illnesses.
2. Is Lithium orotate dangerous?
Lithium is referred to as a drug because lithium compounds, also referred to
as lithium salts, are basically used as a psychiatric medication. They are basically used
to cure bipolar disorders and manage major depressive illnesses which doesn’t
improve after the application of antidepressants. In these diseases, lithium orotate
high dose lowers the risk of suicide.

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3. Lithium orotate supplement- How does it work?
The orotate ingredient is very crucial since it delivers lithium in its bioactive form
enabling your body to absorb it. Lithium orotate mechanism of action shows in
several levels, from microscopic to macroscopic levels. Lithium orotate modulates
gabaergic neurotransmission and dopaminergic glutamatergic.
Lithium orotate has also demonstrated neuroprotective positive effects in several
brain regions. This is evidenced by changes in the volume of grey matter. Lithium
orotate supplement provides you with both neuroproliferative and neuroprotective
positive effects thanks to its ability to preserve the grey matter.
Lithium orotate also modulates neurotransmitters. It blocks excitatory
neurotransmitters including glutamate and dopamine, while promoting
GABA-mediated neurotransmission.
Lithium orotate causes downregulation of NMDA receptors which is a subtype of
glutamate receptor. Lithium induces the NMDA receptor, raising availability of
glutamate in the postsynaptic neuron.

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4. Lithium orotate research- what does it do?
Prescription-strength lithium orotate is regarded as a potent neuroprotective agent.
It is being widely studied in specific neurodegenerative disorders such as Parkinson’s
disease, Alzheimer’s disease, and ALS (amyotrophic lateral sclerosis). It has been
proved to cause disruption of glycogen synthase kinase-3, which is a crucial enzyme
that causes the development of neurofibrillary tangles and amyloid plaques that are
associated with A.D. (Alzheimer’s disease.)
5. Lithoum orotate effects- What are the benefits of
lithium orotate?
Discussed below are some of the lithium orotate benefits in high dose and low dose.
i. Management of Dementia and Alzheimer’s
Lithium orotate high dose of 10 µg per every liter of water gave a lower rate of
dementia by a whopping 17 percent. However, lithium orotate dosage of 5 to 10 µg
per liter was associated with a 22 percent rise in dementia. This shows that lithium
orotate dosage is highly sensitive and the benefits it provides will largely depend on

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the dosage used. Lithium orotate supplements also provide protective stress
responses and neuroprotection.
ii. Low-dose lithium orotate for mood
Very low doses of lithium assist greatly for complex mood challenges. Low lithium
orotate dosage is enough to really help in the management of depression. Let us
compare the 150 mg, which is the smallest dose made and 900 to 1500 mg per day,
which is one of the highest lithium orotate dosage made.
If you have manic-depressive disease, you need to take lithium orotate high dose to
get enough blood levels. Lithium orotate blood levels varies greatly from an
individual to another, so a few laboratory tests are usually required to ensure your
level is known before taking a dose.
As a usual procedure, when an antidepressant drug for Major Depression has failed
to work alone, addition of low-dose lithium is a standard option. This routine is
incorporated in the international depression treatment guidelines.
iii. Low-dose lithium orotate prevents suicide

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Lithium is always found in the water of various cities around the globe. Surprisingly,
those towns have comparably lower rates of suicide than neighboring cities with no
or little lithium in their water. According to the studies conducted, the higher the
level of lithium, the lower the rate of suicide.
With lithium orotate supplement, people can possibly add some lithium in their
drinking water and this could be beneficial.
Lithium orotate in the management of Neurological conditions
Lithium orotate can be used in the management of various neurological illnesses.
These illnesses include dementia, Alzheimer, ADHD, ADD, aggressive and violent
behaviors.
Different researchers have found out that administering lithium orotate to dementia
patients can assist with biologic and behavioral issues. It can provide positive results
to Alzheimer’s-dementia patients too. It has shown to keep neurons alive in humans
and animals in several studies. Enhanced focus can assist ADD patients and stabilize
those who have ADHD.
iv. Lithium orotate brain positive effects

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One of the most important lithium orotate benefits is that it protects the brain
through the production of new brain cells and protection against the loss of brain
cells. It has also shown to reverse dementia, Parkinson’s, and Alzheimer’s disease.
Animal studies on lithium orotate brain effects showed improvement in strokes and
traumatic brain injuries. It can also provide benefits as a protectant against damage
of the central nervous system due to Lyme disease. Other lithium orotate brain
effects include:
 Protect the brain against brain shrinkage.
 Protects brain cells from toxins and infections
 Boosts growth of new brain cells
v. Lowering Anxiety from PTSD and Management of Bipolar Disorder
People with bipolar disorder may take lithium orotate together with their lithium
drug prescription to lower symptoms. The acid content in lithium orotate may boost
absorption of prescribed lithium carbonate. Lithium orotate supplement may also
assist reduce the prescription version.
Lithium orotate may also help those who are suffering from severe anxiety from
PTSD and may assist as a stabilizer after panic attacks.

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vi. Lithium orotate and alcohol intake management
Daily treatment with lithium orotate helped alcohol addicts who wanted to quit
alcohol intake. Lithium orotate benefits in assisting other addictive behavioral
patterns are there as well. Those who suffer from obsessive and OCD disorders may
benefit from it. Lithium orotate and alcohol intake control has been a major area of
study. Scientists believe lithium orotate can help cope during the process of
rehabilitation besides counseling therapy use.
vii. Low dose lithium orotate can lower inflammation
Lowering inflammation is one of the most crucial lithium orotate benefits to our
health. In these days, we have more toxins in our environment and diet than ever

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before. These toxins raise the level of inflammation causing several
diseases. Research has demonstrated that lithium orotate seems to lower
inflammatory proteins while increasing anti-inflammatory proteins.
In recent research lithium orotate showed neuroprotective effects against
autoimmunity of the nervous system. This study in animals showed that lithium
suppressed the production of IFN-γ, which is associated with A.D (Alzheimer’s
disease.)
viii. Lithium orotate depression lowering effects
Low-dose lithium is very effective in the treatment of depression. Most studies have
found out that low-dose lithium orotate is equally as potent as a high dose with little
to no side effects.
Lithium orotate depression lowering effects are associated with its ability to boost
5-HT neurotransmission (“happy” neurotransmitter) receptors. This effect stimulates
antidepressant action in the brain, combating depression.
ix. Uses of lithium orotate high dose

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For over a century, lithium orotate high dose (typically 300-1200+ mg per day) has
been applied in pharmacological doses to cure bipolar disorders and other mood
related disorders. Lithium orotate high dose is also being studied and used to lower
the progress of dementia, ALS, and Alzheimer’s disease.
6. Who can benefits from lithium orotate?
At least 3 or more groups of people should consider taking lithium orotate. These
groups include:
People whose parents have Alzheimer’s dementia
You have probably heard of a study that proved lithium might decrease the risk of
Alzheimer’s dementia. If you have a parent with Alzheimer’s, you should be
interested in low-risk step which you could take which might lower the chances of
getting this condition yourself.
If your parents became ill while young, or you already see in yourself some signs of
decline in memory, you may feel that you do not have time to wait for more clinical
research.

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People who struggled with thoughts regarding suicide
People who struggled with suicide thoughts should consider taking low dose lithium
orotate supplements because small amounts of lithium in an area’s water supply
have been associated with low suicide rates in those areas. You may consider
lithium orotate if you have ever experienced suicide thoughts and you need some
assistance to eliminate the stress.
People suffering from anxiety
Lithium orotate is popular for its antipsychotic positive effects in patients with
bipolar. Because of this, effects of lithium orotate lower doses are being studied in
persons with anxiety. Lithium orotate has been proved in several studies to calm
down manic behavior related to (ADHD) attention deficit disorder, anxiety, and
bipolar disorder.
Even if most of these investigations involve more extreme cases and always apply
lithium carbonate, that is more aggressive form of lithium, many practitioners have
reportedly used low-dose lithium orotate for management of anxiety.

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People who want to boost their cognitive function
Lithium orotate brain effects are simply amazing. Low dose lithium orotate has been
proved to be neuroprotective and to boost cognition.
One of the lithium orotate mechanism of action is to boost BDNF (brain-derived
neurotrophic factor), which is crucial to good brain function. Lithium orotate also
block glycogen synthase kinase-3 action that is involved in intracellular signaling.
Lithium orotate also lowers calcium-dependent stimulation of pro-apoptotic signaling
pathways. This assists to lower the rate of cell death. Lithium orotate longevity
benefits are also supported by its ability to lower the rate of cell death.

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7. Lithium food sources?
Lithium is a light metal which is highly reactive and naturally found in minute levels
throughout the human body. Other lithium orotate sources include:
 Dietary supplements
 Drinking water
 Grains
 Mustard
 Pistachios
 Dairy
 Kelp
 Fish
 Meat
 Vegetables
8. Lithium orotate half life - How long does lithium
orotate take to work?
It normally takes a few weeks for lithium orotate to start working. Your health care
professional will ask for blood tests receiving lithium orotate treatment. This is
because lithium orotate can influence how well your thyroid or kidney functions

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because it functions best if the lithium amount in your system is maintained at a
constant level.
9. Lithium orotate experience: How to take lithium
orotate?
How much lithium orotate should I take?
The daily lithium orotate dosage should be between 0.3 to 5 milligrams. This amount
of lithium could practically protect your brain.
What is the best time to use lithium orotate supplements?
Lithium orotate tablet supplements should be taken one time per day at
night. Lithium liquid supplements are usually taken two times per day.
Lithium orotate level in the blood need to be taken not earlier than five to seven days
after treatment begins.

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How much lithium orotate should I take for depression?
More often than not, the lowest lithium orotate dosage is sufficient to help with
depression. Lithium orotate can therefore be used in lower doses such as 5 mg with
amazing results and without any lithium orotate side effects. A clinical study involving
150 mg daily lithium orotate dosage given four to five times per week, showed a
decrease of depressive and maniac symptoms in patients with depression.
How long will you have to take Lithium Orotate?
Lithium orotate should be taken for at least six months when taking 150mg per
day. An open research involving 42 patients investigated the effects of lithium
orotate 150 mg per day administered over 6 months. The study demonstrated that
this period was enough for lithium orotate to treat depression, alcoholism, and even
migraines.

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10. Is it safe to use Lithium Orotate? Lithium orotate
Side Effects and safety
A majority of lithium orotate side effects may be avoided by taking the correct
lithium dosage or through careful monitoring by a health care professional.
The smaller the amount of active lithium orotate contained in a supplement the
more likely you’re able to avoid possible lithium orotate dangers.
Some people experienced the following lithium orotate side effects after taking the
supplement:
 Headaches

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 Nausea
 Tremors (usually in the hands)
 Vomiting
 Increased thirst
 Constipation
 Dry mouth
 Increased urination
 Stomach discomfort
 Drowsiness
 Acne
 Diarrhea
 Feeling slightly “disconnected.”
It was also reported that lithium orotate cause weight gain when taken in high
amounts. Reducing the dosage may alleviate or lower these lithium orotate side
effects.
There is very little clinical information concerning lithium orotate interactions with
other drugs. More studies in humans will be required to determine lithium orotate
interactions with other drugs.

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11. The differences between lithium orotate and
lithium
Lithium orotate and lithium differ in that lithium orotate is a supplement or
over-the-counter nutraceutical which consists of orotic acid and lithium while lithium
is an alkali metal. Orotic acid which is a component of lithium orotate is produced in
the body naturally. Orotic acid is inactive but is used in this compound to act as a
carrier for the active component which is lithium. On the other hand, lithium as an
alkali metal is normally present in the diet, mainly in vegetables and grains. Lithium
element is also present in our drinking water. That’s basically how lithium orotate
and lithium differ.
12. Lithium orotate vs lithium aspartate
Lithium aspartate is another low-dosage lithium route. Whereas lithium orotate is
marketed for the special ability of orotate to deliver lithium, aspartate on the other
hand is not regarded as special. Aspartate is just another ion that carries lithium, just
like the carbonate ion present in the normal prescription lithium.
You can also buy lithium aspartate online. After aspartate leaves lithium aspartate
ion is left in the body in small amounts. As with carbonate, aspartate is safe because
it is an amino acid which we take in proteins all the time.

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Since there’s no enough clinical data to show how effective lithium aspartate is, the
safest route for now is to use low-dose lithium orotate.
13. FAQs of lithium orotate
–Take lithium orotate supplement will cause the weight gain?
The claim that lithium orotate cause weight gain is true to some extent. Although
there is possibility of weight gain while taking lithium orotate, this side effect doesn’t
affect every person who takes the supplement.
–How does lithium orotate do the brain?
Lithium Orotate has been proven to support memory and mood while improving
cognition and overall brain health. Lithium orotate also protects the brain cells
against damage.
– Does lithium orotate help with anxiety?

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Yes, lithium orotate powder has been used to lower anxiety for many years. It has
also been highly effective in the management of mood swings, attention deficit
disorders as well as anger and aggression.
– Does lithium orotate make you sleepy?
Lithium orotate is very useful in the regulation of sleep-wake cycle. However, high
doses may cause drowsiness which may make you feel sleepy.
– Can Lithium Orotate help depression?
Yes, Lithium orotate is very useful in lowering depression. Clinical experiments
involving lithium orotate 150 mg daily dose administered four to five times per week,
showed a remarkable decrease in symptoms associated with depression.
– Does lithium orotate affect thyroid?
Lithium orotate low dosage doesn’t cause much risk to thyroid. But lithium at a
slightly higher dose can cause thyroid issues either getting too low which is known as
hypothyroid or in rare cases getting too high which is known as hyperthyroid. Ten
percent of people may get this problem.

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– Is Lithium Orotate (LO) supplementation safe for everyone?
When taken in low doses, Lithium Orotate (LO) supplementation is safe for everyone.
All clinical studies carried out shows that lithium orotate dangers are very rare and
the supplement is highly effective in neuroprotection functions.
–What is lithium orotate half life?
Lithium orotate half life is 24 hours.
– Lithium orotate for sale - Where to buy lithium orotate powder?
You can buy lithium orotate powder online or from your local foods and supplement
store. If you want to place a lithium orotate powder bulk order, feel free to do so
from our website. We are a reliable and experienced lithium orotate powder supplier
who has the ability to deliver the lithium orotate supplement to your location.
【References】

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1. Chiu CT and Chuang DM. Neuroprotective action of lithium in disorders of the
central nervous system. Zhong Nan Da Xue Xue Bao Yi Xue Ban,
2011;36(6):461-76.
2. Nunes, M.A., et al., Chronic Microdose Lithium Treatment Prevented Memory
Loss and Neurohistopathological Changes in a Transgenic Mouse Model of
Alzheimer’s Disease. PLoS One, 2015. 10(11): p.e0142267.
3. Smith, D. F.; Schou, M. (March 1979). “Kidney function and lithium
concentrations of rats given an injection of lithium orotate or lithium
carbonate”. The Journal of Pharmacy and Pharmacology. 31 (3): 161–163.
4. Ina Bach; Otto Kumberger; Hubert Schmidbaur (1990). “Orotate complexes.
Synthesis and crystal structure of lithium orotate( – I) monohydrate and
magnesium bis[ orotate( – I)] octahydrate”. Chemische Berichte. 123 (12):
2267–2271.
5. lithium orotate

Lithium orotate experience: What can you get from taking lithium orotate?

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Lithium orotate experience: What can you get from taking lithium orotate?