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Leukocyte adhesion deficiency HY

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Rickettsia Rickettsii
Rickettsia Rickettsii

Leukocyte adhesion deficiency

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Leukocyte adhesion deficiency Pathophysiology • Defect in CD18-containing integrins • Impaired leukocyte adhesion & endothelial transmigration Clinical features • Skin & mucosal infections (eg, cellulitis, periodontitis) without pus formation • Impaired wound healing • Delayed umbilical cord separation (age >3 weeks) Laboratory findings • Leukocytosis & neutrophilia

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Leukocyte adhesion deficiency HY

  • 1. Leukocyte adhesion deficiency Pathophysiology • Defect in CD18-containing integrins • Impaired leukocyte adhesion & endothelial transmigration Clinical features • Skin & mucosal infections (eg, cellulitis, periodontitis) without pus formation • Impaired wound healing • Delayed umbilical cord separation (age >3 weeks) Laboratory findings • Leukocytosis & neutrophilia