Cell biology Want to know the difference between Centrioles and Centrosome? Check this ppt to know more about it! -- Importance of these cellular organelles in a life. -- Disorders related to these organelles. -- Recent advancements in the field of Cancer and Cell biology. By Mohammed Valikarimwala SY BSc Biotechnology Fergusson college, Pune.

1. MOHAMMED VALIKARIMWALA
FERGUSSON COLLEGE, PUNE
CELL BIOLOGY CENTRIOLE AND
CENTROSOME

2. • A centriole is a small set of microtubules arranged in a specific way.
• There are nine groups of microtubules.
• When two centrioles are found next to each other, they are usually at right angles.
• The centrioles are found in pairs and move towards the poles (opposite ends) of the nucleus
when it is time for cell division.
• During division, you may also see groups of threads attached to the centrioles. Those threads
are called the mitotic spindle.
About Centrioles…

3. • The centrosome, a key microtubule
organizing centre, is composed of
centrioles, embedded in a protein-rich
matrix.
• Centrosomes control the internal spatial
organization of somatic cells, and as such
contribute to cell division, cell polarity
and migration.
• Every animal-like cell has two small
organelles called centrioles.
• One bundle has a set of three
microtubules, which are made from a
protein called tubulin.

5. • When mutations occur in the genes that are responsible for the proteins found in
centrioles, problems and genetic diseases can happen.
• It is important to note that in a fertilized egg the centrioles only come from the male’s
sperm because a female’s egg does not contain them.
• Researchers have found that the original centrioles from the sperm are able to survive
multiple cell divisions in the embryo.
• Although centrioles do not carry genetic information, their persistence in a developing
embryo means they can contribute other types of information.
Centrioles and Diseases
Centrioles are important organelles inside cells. They are part of cell division, cilia and
flagella. However, when problems occur, they can lead to several diseases.

6. • Researchers have discovered that cancer cells often have more centrioles than necessary.
• Not only do they have extra centrioles, but they also have longer ones than normal.
• However, when scientists removed centrioles from cancer cells in a study, they found that
the cells could continue to divide at a slower rate.
• They learned that cancer cells have a mutation in p53, which is a gene that codes for a
protein responsible for controlling the cell cycle, so they can still divide.
• Scientists believe this discovery will help improve cancer treatments.
Centrioles and Cancer
“Abnormal Rise in the Number of Centrioles can Induce Cancer” –28th Mar, 2018.
Medindia.net

7. Recent studies on Centrioles and it’s related
disorders

8. References
• Centrioles, Centrosomes and Cilia in Health and Disease (Eric and Jordan,2009)
• https://www.medindia.net/news/abnormal-rise-in-the-number-of-centrioles-
can-induce-cancer-178248-1.htm
• http://www.biology4kids.com/files/cell_centriole.html
• https://sciencing.com/happens-child-born-extra-chromosome-23rd-pair-
15692.html
• https://royalsocietypublishing.org/doi/full/10.1098/rstb.2013.0468#d3e273
• https://www.genengnews.com/topics/translational-medicine/cancers-of-many-
kinds-give-centriole-amplification-starring-role/
• https://www.ncbi.nlm.nih.gov/pubmed/29593297