This document provides an overview of Chlamydia and Chlamydophila, including their taxonomy, structure, growth cycle, and role in human disease. It describes how they are small, obligate intracellular bacteria that alternate between infectious elementary bodies and metabolically active reticulate bodies. Key points covered include how they infect epithelial cells and have a unique developmental cycle, as well as the different species and strains that cause diseases like trachoma, pneumonia, and sexually transmitted infections.
1. A Presentation by M. Isaac Umapathy, Dept. of Microbiology & Parasitology, Faculty of Medicine, International Medical & Technological University, Dar-Es-Salaam, Tanzania . CHLAMYDIA & CHLAMYDOPHILA
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17. Comparison of Chlamydial Elementary Body & Reticulate Body More Few Projections & rosettes Sensitive Resistant Trypsin digestion Active, replicating stage Relatively inactive Metabolic activity 3:1 (increased ribosomes) 1:1 (condensed DNA core) RNA:DNA ratio Non-infectious Infectious Infectivity to host Fragile, pleomorphic Electron dense core; rigid Morphology 1 µm 0.2 - 0.3 µm Size Reticulate Body Elementary Body Characteristic