Powerpoint presentation defining HPI\'s approach and qualifications for our clients

1. Presentation of Our Qualifications on Leadership Solutions through retained search Spring 2010

2. CONTENTS 11 Examples of Completed Work 7 8 9 HPI: Best of Both Large and Small Firms Quality Your HPI Team 4 5 6 Value Proposition Client Service Orientation Geographic Reach 1 2 3 Overview Applied Spine Tech. - Search Target List Our Experience Covers the Value Chain HPI’s Credentials & Approach

3. OVERVIEW: WHAT WE DO The most successful organizations have the most effective leadership teams. The active management of leadership capital has emerged as a critical success factor for all organizations, particularly during times of change and uncertainty. Working with the leadership of global business, we know how to develop and execute comprehensive leadership capital strategies. We help our clients to Acquire, Assess and Develop their top leadership talent. Service Spotlight Team Building From organizational design and benchmarking to recruiting, our consultants have extensive track records including broad functional depth from building Boards and recruiting most line and staff roles – we have completed more than 500 searches during our careers. Executive Assessment We help you better understand the capabilities and potential of your leadership team through competency-based assessments of leaders benchmarked against the industry’s talent Professional Development We work closely with some of the best consultants in the industry to maximize the performance of individuals and teams through executive coaching and education. Strategy Organizational Design Organizational Benchmarking Recruiting Coaching/ Education Leadership Development Organizational Assessment Executive Talent Management Model Page 1 Overview HPI’s Credentials & Approach Quality & Fee Structure Your Search Team Examples of Completed Work

4. INITIAL TARGET LIST Page 2 Initial Target List for Applied Spine Technologies Overview HPI’s Credentials & Approach Quality & Fee Structure Your Search Team Examples of Completed Work

11. Kevin M. Butler Kevin Butler is a co-founder and the President and Managing Partner of Heritage Partners International (HPI), a retainer-based, human capital strategy consultancy with offices in Philadelphia, New Haven and Morristown. Mr. Butler is based in New Haven and concentrates primarily on senior-level life sciences searches and other related human capital issues. During the past 13 years, he has served a broad range of pharmaceutical, biotech and medical device clients around the globe. He has successfully recruited hundreds of non-executive Directors, Chief Executive Officers, Chief Operating Officers and Vice Presidents in most line and staff functions for clients ranging from major multinationals to venture-backed start-ups. Prior to starting HPI, he was the Global Managing Partner for Heidrick & Struggles’ Health Care Practice. Earlier he led the Global Medical Device and Diagnostics Practice at Spencer Stuart. Mr. Butler began his search career with Russell Reynolds where he started and led their Healthcare Information Technology Practice. Before entering search, he had executive roles with Pfizer and Johnson & Johnson, and was a strategic management consultant with Marakon Associates and Dynamics Research Corporation. Mr. Butler spent 8 years on active duty in the US Army as an Armor, Cavalry and Infantry officer serving around the world. A native of Massachusetts, Kevin is a graduate of The US Military Academy at West Point where he received a B.S. in Engineering. He received an MBA from The Wharton School at The University of Pennsylvania. Page 9 Overview HPI’s Credentials & Approach Quality & Fee Structure Your Search Team Examples of Completed Work

12. Tig Conger Tig Conger is a partner in Heritage Partners International's New Haven, CT office. He joined the firm in 2004 following a successful 20 year career in commercial operations with Searle, Aventis and Bayer where he was responsible for the successful management of major product launches in a number of therapeutic areas both in the U.S. and Europe. At HPI his work is focused on pharmaceutical and biotechnology companies with particular expertise in sales and marketing assignments. Most recently he was Vice President of Marketing for Bayer's U.S. Pharmaceutical Division where he was responsible for Anti-Infective and Hospital products and previously their cardiovascular products. At Aventis, Tig was Director of Marketing for Cardiovascular and Allergy products and responsible for the development and management of several strategic alliances. Tig's consulting career began at Hayes/Hill where he was a Senior Associate in the strategy practice. Tig is a member of the Board of Trustees for the National Foundation for Infectious Diseases. Mr. Conger is a graduate of Tulane University where he received a B.S. in Engineering. He received an MBA from Columbia Business School. He resides in Milford, Connecticut with his wife Kathy and their four children. Page 10 Overview HPI’s Credentials & Approach Quality & Fee Structure Your Search Team Examples of Completed Work

13. Representative Search Experiences Page 11 Big Pharma Company Position Astra Zeneca Vice President, Discovery Research Executive Director, Medical Affairs Senior Director, Quality Assurance Bayer Pharmaceuticals Chief Scientific Officer Sr. Vice President, Oncology Vice President, Marketing Oncology Director of Clinical Pharmacology Director of Global e-Business Bayer Diabetes President, Diabetes Care Division Chief Financial Officer Vice President Sales Bayer Consumer Care Division SVP, Chief Scientific Officer VP, Global Medical Affairs and Clinical Research Boehringer Ingelheim Director, Medical Affairs OTC Director, Drug Safety (x2) Overview HPI’s Credentials & Approach Quality & Fee Structure Your Search Team Examples of Completed Work

14. Representative Search Experiences Page 12 Big Pharma - continued Company Position Pharmacia Director, Clinical Development Director, Talent Management Sanofi General Manager, Oncology Vice President, Medical Urology Vice President, Managed Care Vice President, New Product Development Senior Director, Marketing Overview HPI’s Credentials & Approach Quality & Fee Structure Your Search Team Examples of Completed Work

15. Representative Search Experiences Page 13 Bio Pharmaceutical Company Position ABC Laboratories Chief Executive Officer Achillion Pharmaceutical Chief Operating Officer Chief Financial Officer Boston Life Sciences Clinical Director, Neurology Clinical Director, Oncology Director, Regulatory Affairs CuraGen Chief Executive Officer Board Member (2) Elusys Vice President, Finance Emisphere Technologies Board Member Chief Operating Officer Director, Marketing Director, Information Systems Enzon Board of Director Chief Executive Officer Vice President, Controller Overview HPI’s Credentials & Approach Quality & Fee Structure Your Search Team Examples of Completed Work

16. Representative Search Experiences Page 14 BioPharmaceutical – cont’d Company Position Exact Sciences Board Member Chief Financial Officer Iomai Vice President, Business Development Histogenics Chief Executive Officer HistoRX Vice President, Sales & Business Development The Jackson Laboratory Associate General Manager, Product Development MMRF/RC President Mojave Therapeutics Chief Scientific Officer Oxford Glycosciences Chief Operating Officer Vice President, Commercial Operations Vice President, Research & Development Optherion Chief Executive Officer Chief Financial Officer Paratek Pharmaceuticals Chief Financial Officer Praecis Pharmaceuticals Senior Vice President, Technology Partnerships Serono Senior Vice President, Neurology Vice President, Neurology Sales Overview HPI’s Credentials & Approach Quality & Fee Structure Your Search Team Examples of Completed Work

17. Representative Search Experiences Page 15 BioPharmaceutical – cont’d Company Position Sopherion Therapeutics Chief Executive Officer Chief Financial Officer Talecris Director, Marketing Tengion Chief Executive Officer Chief Financial Officer Vice President, Manufacturing Vice President, Business Development Vice President, Science & Technology Vice President, Process Research Vice President, Quality Assurance Vion Chief Financial Officer ViroPharma Chief Scientific Officer Overview HPI’s Credentials & Approach Quality & Fee Structure Your Search Team Examples of Completed Work

18. Representative Search Experiences Page 16 Specialty Pharma Company Position Aegerion Vice President, Regulatory Affairs Biovail Vice President, Managed Care Vice President, Manufacturing Cambrex Chief Executive Officer Eyetech Chief Financial Officer Ivax Pharmaceuticals Vice President, Development – Europe Kos Pharmaceuticals Vice President, Business Development Director, Medical Affairs Purdue Pharma Vice President, Corporate Security Executive Director – Quality Assurance Executive Director – Corporate Compliance Senior Director, Manufacturing Compliance Savient Pharmaceuticals Board Member Vice President, Sales Teva Pharmaceuticals Chief Financial Officer Vice President, Human Resources – North America Senior Vice President, Finance and Business Development GM- TSP Head of Respiratory Director, Communications Overview HPI’s Credentials & Approach Quality & Fee Structure Your Search Team Examples of Completed Work

19. Representative Search Experiences Page 17 Devices Company Position Bausch & Lomb Category Leader Category Leader Baxter Health Care Vice President, Manufacturing Vice President, Supply Chain 454 Life Sciences Chief Executive Officer Vice President, Marketing Director, Marketing Fisher Healthcare Vice President, Marketing Kinetic Concepts Chief Executive Officer Division President Vice President, Sales Operations Vice President, Research & Development Smith Industries, PLC Managing Director, Life Sciences Songbird Hearing Chief Executive Officer Thermo Electron Vice President, Marketing Zimmer Board Members (3) Overview HPI’s Credentials & Approach Quality & Fee Structure Your Search Team Examples of Completed Work

20. Representative Search Experiences Page 18 Service Companies Company Position Cobra BioManufacturing Global Head, Business Development Director Sales, Eastern Region Director Sales, Western Region Edelman Worldwide President, International Managing Director, UK International Business Director, Healthcare Institute for Cancer Prevention Chief Development Officer Parexel Consulting Vice President, North American Account Management PHT Laboratories Chief Executive Officer and President Rexam Medical Packaging President, North America SCA Chief Financial Officer Vice President, Human Resources Overview HPI’s Credentials & Approach Quality & Fee Structure Your Search Team Examples of Completed Work

21. Representative Search Experiences Page 19 Technology Platforms Company Position Aderis Pharmaceuticals Vice President, Medical Affairs Director, Business Development Althexis Chief Executive Officer and President Alkermes Vice President, Medical Affairs Genelabs Vice President, Business Development Impath Laboratories Board Member Overview HPI’s Credentials & Approach Quality & Fee Structure Your Search Team Examples of Completed Work

22. Representative Search Experiences Page 20 Other Company Position Barnev Chief Executive Officer Empower Health (VC) Chief Financial Officer Innomed Ventures (VC) General Partner Schroder Ventures General Partner Sharp (VC) Chief Executive Officer SSG (VC) Chief Operating Officer Chief Financial Officer Overview HPI’s Credentials & Approach Quality & Fee Structure Your Search Team Examples of Completed Work