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PATOFISIOLOGI SLE
Faktor
Genetik
Faktor
Lingkunga
n
Faktor
Hormonal
Sinar UV
Stres
Berlebihan
Infeksi Obat-
obatan
- Prokainam
id
- Hidralazin
- minosiklin
Lupus eritematosus
yang diinduksi obat
Obat berikatan
dengan kompleks
antibodi
Produksi
estrogen
meningkat
Merangsan
g sistem
imun
Kelainan sistem imun
Respon imun
abnormal
Hiperreaktivitas dan hipersensitivitas limfosit
T dan B
Membentuk kompleks imun
Terjadi Inflamasi
Merusak sel dan
jaringan / organ
SSP Otot dan
kerangka
Mukosa
- Pusing
- Kekacaua
n ingatan
- Gangguan
penglihat
an
- Kejang
- psikosis
Mikrotraum
a
Gastrointestina
l
Pleuriti
s
Paru-paru
Peradangan
selaput
paru-paru
Artritis
- Nyeri
sendi
- Nyeri otot
Keluarnya
nukleus sel
epitel oral
Memicu
respon imun
- Sariawan
- Luka di
mulut
Inflamasi
autoimun pada
kelenjar
lakrimal dari
saliva
Mata dan
mulut
kering
Efek obat-
obatan
glukokortikoid
- Mual
- Muntah
- Nyeri
perut
-
Pneumoniti
s
Efusi
pleura
Penimbunan
cairan antara
paru-paru dan
pembungkusny
a
- Nyeri dada
- Sesak
Jantung
Peradangan
di berbagai
bagian
jantung
- Perikarditis
- Endokarditi
s
- Miokarditis
- Nyeri dada
- Aritmia
Merusak sel dan
jaringan / organ
Ginjal Darah
- Sesak
- Mudah lelah
- Pusing
- Konjungtiva
anemis
Kulit
Penimbunan
protein dalam
sel-sel ginjal
Peradanga
n
Nefritis
lupus yang
menetap
Proses
infiltrasi
terganggu
Urin
mengandung
banyak
protein
(proteinurea)
Urin
mengandung
banyak darah
(hematuria)
Eritrosit
Anemia
Erotrosit ↓
Hb ↓
O2 ↓
Suplai O2
keseluruh
tubuh ↓
Leukost
Leukopeni
a
Mudah
infeksi
Trombos
it
Antibodi
anti
fosfolipid
Trombositope
nia
Pelepasan materi inti oleh
sel kulit yang dirusak cahaya
Alopesia
- Pendarahan
- Mimisan
- Bintik merah di
kulit
Induksi epitop antigen
di dermis atau
epidermis
Pelepasan mediator
imun
Disregulasi sel imun
kulit
- Ruam kupu-
kupu pada
pipi dan
pangkal
hidung
- Ruam di
pergelangan
tangan
- Purpura
Lesi pada
kulit
kepala

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Patofisiologi sle

  • 1. PATOFISIOLOGI SLE Faktor Genetik Faktor Lingkunga n Faktor Hormonal Sinar UV Stres Berlebihan Infeksi Obat- obatan - Prokainam id - Hidralazin - minosiklin Lupus eritematosus yang diinduksi obat Obat berikatan dengan kompleks antibodi Produksi estrogen meningkat Merangsan g sistem imun Kelainan sistem imun Respon imun abnormal
  • 2. Hiperreaktivitas dan hipersensitivitas limfosit T dan B Membentuk kompleks imun Terjadi Inflamasi Merusak sel dan jaringan / organ SSP Otot dan kerangka Mukosa - Pusing - Kekacaua n ingatan - Gangguan penglihat an - Kejang - psikosis Mikrotraum a Gastrointestina l Pleuriti s Paru-paru Peradangan selaput paru-paru Artritis - Nyeri sendi - Nyeri otot Keluarnya nukleus sel epitel oral Memicu respon imun - Sariawan - Luka di mulut Inflamasi autoimun pada kelenjar lakrimal dari saliva Mata dan mulut kering Efek obat- obatan glukokortikoid - Mual - Muntah - Nyeri perut - Pneumoniti s Efusi pleura Penimbunan cairan antara paru-paru dan pembungkusny a - Nyeri dada - Sesak Jantung Peradangan di berbagai bagian jantung - Perikarditis - Endokarditi s - Miokarditis - Nyeri dada - Aritmia
  • 3. Merusak sel dan jaringan / organ Ginjal Darah - Sesak - Mudah lelah - Pusing - Konjungtiva anemis Kulit Penimbunan protein dalam sel-sel ginjal Peradanga n Nefritis lupus yang menetap Proses infiltrasi terganggu Urin mengandung banyak protein (proteinurea) Urin mengandung banyak darah (hematuria) Eritrosit Anemia Erotrosit ↓ Hb ↓ O2 ↓ Suplai O2 keseluruh tubuh ↓ Leukost Leukopeni a Mudah infeksi Trombos it Antibodi anti fosfolipid Trombositope nia Pelepasan materi inti oleh sel kulit yang dirusak cahaya Alopesia - Pendarahan - Mimisan - Bintik merah di kulit Induksi epitop antigen di dermis atau epidermis Pelepasan mediator imun Disregulasi sel imun kulit - Ruam kupu- kupu pada pipi dan pangkal hidung - Ruam di pergelangan tangan - Purpura Lesi pada kulit kepala