Cancer-associated VTE is a critical complication in patients with cancer. However the pathological findings of VTE are limited. Here are investigated the histopathological features of cancer-associated VTE in human autopsy cases.
3. Vascular Biology
HIGHLIGHTS
- Autopsy cases (a retrospective study) of tumor-associated venous thromboembolism
(TA-VTE) showed the presence of cancer cells in thrombi positive for Tissue Factor (TF)
or Podoplanin (PDPN) at the immunohistochemical analysis.
- In cancer-associated venous thromboembolism (TE), high frequency of TF-positive monocyte
macrophages more than in venous TE without cancer.
- Neutrophil Extracellular Traps (NET) in the thrombi were related to the early phase of the
thrombus-organizing process, apart from the staging of the Patient.
18. Vascular Biology
FUTURE PERSPECTIVES
- A perspective “in vivo” study;
- A shorter time lapse;
- The use of TF and the “entrapped” neutrophils (+/- neutrophilia) as positive predictive
prognostic factors for DVT and PA-TE in cancer Patients +/- microthrombosis.
19. Vascular Biology
HIGHLIGHTS
- Autopsy cases (a retrospective study) of tumor-associated venous thromboembolism
(TA-VTE) showed the presence of cancer cells in thrombi positive for Tissue Factor (TF)
or Podoplanin (PDPN) at the immunohistochemical analysis.
- In cancer-associated venous thromboembolism (TE), high frequency of TF-positive monocyte
macrophages more than in venous TE without cancer.
- Neutrophil Extracellular Traps (NET) in the thrombi were related to the early phase of the
thrombus-organizing process, apart from the staging of the Patient.