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University of Miyazaki
Vascular Biology
Vascular Biology
HIGHLIGHTS
- Autopsy cases (a retrospective study) of tumor-associated venous thromboembolism
(TA-VTE) showed the presence of cancer cells in thrombi positive for Tissue Factor (TF)
or Podoplanin (PDPN) at the immunohistochemical analysis.
- In cancer-associated venous thromboembolism (TE), high frequency of TF-positive monocyte
macrophages more than in venous TE without cancer.
- Neutrophil Extracellular Traps (NET) in the thrombi were related to the early phase of the
thrombus-organizing process, apart from the staging of the Patient.
Vascular Biology
BACKGROUND
TF+ Macrophages
(Alveolar wall)
Vascular Biology
BACKGROUND
TF+ Macrophages
(Pancreas AdK)
Vascular Biology
BACKGROUND
TF+ Macrophages
(Pancreas AdK)
Vascular Biology
BACKGROUND
PDPN+ Macrophages
(Cutaneous Squamous Cell Ca.)
Vascular Biology
PDPN+ Macrophages
(Cutaneous Squamous Cell Ca.)
BACKGROUND
Vascular Biology
BACKGROUND
PDPN+ Macrophages
(Cutaneous Squamous Cell Ca.)
Vascular Biology
MATERIALS AND METHODS
Major Resources Table
Vascular Biology
RESULTS
Vascular Biology
RESULTS
Deep Venous Thrombosis
(Pancreas AdK)
DVT (Gastric AdK)
Vascular Biology
RESULTS
Deep Venous Thrombosis
(Pancreas AdK)
DVT (Gastric AdK)
Vascular Biology
RESULTS
Pulmonary Arteries
(Cutaneous Squamous Cell Ca.)
RESULTS
Pulmonary Arteries
(Cutaneous Squamous Cell Ca.)
Vascular Biology
RESULTS
LYTIC NEUTROPHILS
Neutrophils
Extracellular
Traps
(NET)
Vascular Biology
RESULTS
Neutrophils
Extracellular
Traps
(NET)
LYTIC NEUTROPHILS
Vascular Biology
Vascular Biology
FUTURE PERSPECTIVES
- A perspective “in vivo” study;
- A shorter time lapse;
- The use of TF and the “entrapped” neutrophils (+/- neutrophilia) as positive predictive
prognostic factors for DVT and PA-TE in cancer Patients +/- microthrombosis.
Vascular Biology
HIGHLIGHTS
- Autopsy cases (a retrospective study) of tumor-associated venous thromboembolism
(TA-VTE) showed the presence of cancer cells in thrombi positive for Tissue Factor (TF)
or Podoplanin (PDPN) at the immunohistochemical analysis.
- In cancer-associated venous thromboembolism (TE), high frequency of TF-positive monocyte
macrophages more than in venous TE without cancer.
- Neutrophil Extracellular Traps (NET) in the thrombi were related to the early phase of the
thrombus-organizing process, apart from the staging of the Patient.
“QUESTIONS?”
Thank You
Credits: Unicatt
Credits: Miles7one

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Daniele Amato - Cancer-associated Venous Thromboembolism