MOLECULAR BIOLOGY

1. DNA REPARATION
MARIA CATALINA SOTO LOPEZ
MEDICINE STUDENT

4. INTRODUCTION

5. STUDY CHARACTERIZES KEY
MOLECULAR TOOL IN DNA
REPAIR ENZYMES
University of North Carolina at
Charlotte.
(2017,january 6).

6. STUDY CHARACTERIZES KEY
MOLECULAR TOOL IN DNA REPAIR
ENZYMES
The DNA needs constant maintenance for it have found a set of molecules that
detect oxidative damage to sections of DNA molecules

7. STUDY CHARACTERIZES KEY
MOLECULAR TOOL IN DNA REPAIR
ENZYMES
• The Zf-GRF is found in
several molecules that
work for the maintenance
of DNA including APE2
which is an enzyme that is
activated when DNA
damage occurs and
subsequently generate its
repair

8. STUDY CHARACTERIZES KEY
MOLECULAR TOOL IN DNA REPAIR
ENZYMES
If DNA repair is not generated after
suffering oxidative damage this can
contribute to the appearance of
various diseases such as cancer

9. STUDENT´S OPINION
• It seems to me very important because having
knowledge on this subject could be of great help to
intervene in the progression of cancer or other
diseases related to oxidative stress and possible
solutions would be obtained on the therapeutic
measures of these diseases in the near future.

10. PEOPLE WITH FORMS OF
EARLY-ONSET PARKINSON'S
DISEASE MAY BENEFIT FROM
BOOSTING NIACIN IN DIET
University of Leicester.
(2017,January 10).

11. PEOPLE WITH FORMS OF EARLY-ONSET
PARKINSON'S DISEASE MAY BENEFIT FROM
BOOSTING NIACIN IN DIET
Niacin is necessary for the proper
functioning of the brain since it
intervenes in the process of synthesis
of certain neurotransmitters such as
serotonin being thus partly
responsible for our good mood. In
addition to being very useful in cases
of schizophrenia, psychosis ...

12. PEOPLE WITH FORMS OF EARLY-ONSET
PARKINSON'S DISEASE MAY BENEFIT FROM
BOOSTING NIACIN IN DIET
• In some cases Parkinson's disease may occur due to a defect in the PINK1
gene, which is found on the outer membrane of the mitochondria, and this is
where the researchers' effect of niacin

13. PEOPLE WITH FORMS OF EARLY-ONSET
PARKINSON'S DISEASE MAY BENEFIT FROM
BOOSTING NIACIN IN DIET
• After the study it can be
determined that niacin would allow
the mitochondria to be maintained
in a good state and with it the more
controlled family parkinson's
disease

14. STUDENT´S OPNINION
• It seems to me a very good research since
although it is not the cure for the disease, it is
an improvement for the quality of life that
these patients lead mainly because of the easy
obtaining of the NAD since it would not be at
the hand of some Few, but the therapeutic
effect would be available to all.

15. MEDICAL UTILITY

16. MEDICAL UTILITY
• Finding therapeutic pathways in a
disease such as Parkinson's is very
useful because it would have a great
impact on the deteriorated quality
of life that these patients carry.

17. MEDICAL UTILITY
Discovering this type of enzymes such as Zf GRf can be very useful as they can be
manipulated to intervene in the evolution of some disease such as cancer

18. MEDICAL UTILITY
• Both investigations, especially that
of the enzyme, may have an
impact on morbidity rates,
increase the half-life in a patient
suffering from cancer or other
disease related to oxidative
damage

19. BIBLIOGRAPHY
University of North Carolina at Charlotte. (2017 January 6) "Study characterizes key molecular tool in
DNA repair enzymes." ScienceDaily. Retrieved february 5, 2017 from
<www.sciencedaily.com/releases/2017/01/170106150915.htm>.
University of Leicester.(2017 January 10) "People with forms of early-onset Parkinson's disease may
benefit from boosting niacin in diet, research suggests.". ScienceDaily. Retrieved February 5,2017 from
<www.sciencedaily.com/releases/2017/01/170110092059.htm>.