Mesenchymal stem cells surpassed hematopoietic stem cells as the most frequently cited stem cell type in scientific publications in 2015. This is the first time mesenchymal stem cells have exceeded hematopoietic stem cells in scientific literature. Additionally, mesenchymal stem cells were the only stem cell type to see an increase in publications from 2014 to 2015, while the other four stem cell types analyzed decreased over this period. These findings indicate research companies should prioritize product development, marketing, and relationships for mesenchymal stem cells.

1. Mesenchymal Stem Cells Surpass Hematopoietic Stem Cells in the
Scientific Literature for the 1st
Time in History
Five of the most commonly used stem cell types that are used for research purposes are
embryonic stem cells, mesenchymal stem cells, hematopoietic stem cells, neural stem cells, and
induced pluripotent stem cells. Therefore, the analysis below considers trends in scientific
publication rates for these five stem cell types, over a trailing five-year history. PubMed.gov
scientific publication rate data is used for this analysis because of its comprehensive nature.
1
PubMed is a service of the U.S. National Library of Medicine and the National Institutes of Health
(NIH) that includes over 19 million citations from MEDLINE and other life science journals that
date back to the 1950s.
2
It is the leading search engine through which to search scientific
publications, as NIH researchers are mandated by law to submit their research and most external
research is submitted as well, either voluntarily or by mandate.
3
TABLE. Comparison of Stem Cell Publication Rates, by Stem Cell Type (Five-Year Historical)
YEAR
Embryonic
Stem Cells
Mesenchymal
Stem Cells
Hematopoietic
Stem Cells
Neural Stem
Cells
Induced
Pluripotent
Stem Cells
2011 2,573 2,898 4,215 1,374 969
2012 2,640 3,536 4,519 1,533 1,234
2013 2,701 4,089 4,667 1,696 1,534
2014 2,500 4,283 4,776 1,700 1,565
2015 2,081 4,435 3,797 1,330 1,499
1
Source: Pubmed, http://www.ncbi.nlm.nih.gov/pubmed/. Search Terms: 1) “Embyronic Stem Cell” OR “Embryonic Stem Cells”; 2)
“Mesenchymal Stem Cell” OR “Mesenchymal Stem Cells”; 3) “Hematopoietic Stem Cell” OR “Hematopoietic Stem Cells”; 4) “Neural Stem Cell”
OR “Neural Stem Cells”; 5) “Induced Pluripotent Stem Cell” OR “Induced Pluripotent Stem Cell” OR “iPSC” OR “iPSCs”. Search Executed: January
24, 2106.
2
Ncbi.nlm.nih.gov. 2014. Home - PubMed - NCBI. Available at: http://www.ncbi.nlm.nih.gov/pubmed/. Web . 29 Jan. 2016.
3
Science Codex. Available at: http://www.sciencecodex.com/public_access _mandate_made_law. Web. 29 Jan. 2016.

2. As observed in the graph above, hematopoietic stem cells were the most frequent type of stem
cells to be cited in the scientific literature through 2014. Mesenchymal stem cells were the second
most common stem cell type through 2014.
In 2015, mesenchymal stem cells surpassed hematopoietic stem cells for the first time in
history, to become the most common stem cell type to appear within the scientific
literature.
Additionally, mesenchymal stem cells are the only stem cell type of the five analyzed that had an
increase in scientific publications from 2014 to 2015. All four of the other stem cell types
decreased in scientific publication frequency during that period.
Embryonic stem cell research came in third place among the five stem cell types that were
analyzed, while neural stem cells and induced pluripotent stem cells both showed lower rates of
scientific publications over a trailing five-year period.
These finding have significant implications for research supply companies, because they will
direct company management to:
 Prioritize product development for mesenchymal stem cell products
 Prioritize a marketing budget for existing mesenchymal stem cell products
 Prioritize relationships with mesenchymal stem cell researchers
 Qualify and optimize products for use with mesenchymal stem cells
0
1000
2000
3000
4000
5000
6000
2011 2012 2013 2014 2015
Year-Over-Year Comparison of Stem Cell Scientific
Publications, by Stem Cell Type
Embryonic Stem Cells
Mesenchymal Stem Cells
Hematopoietic Stem Cells
Neural Stem Cells
Induced Pluripotent Stem Cells

3. About BioInformant.com
BioInformant Worldwide, LLC, is the first and only market
research firm to specialize in the stem cell industry.
BioInformant research has been cited by prominent news
outlets that include the Wall Street Journal, Nature
Biotechnology, CBS News, Yahoo Finance, Medical Ethics,
MarketWatch, the Center for BioNetworking, and more.
Our management team comes from a Bioinformatics
background – the science of collecting and analyzing
complex genetic codes – and we are trained in applying
these advanced data analysis techniques to the field of
market research.
Serving Fortune 500 companies that include Pfizer,
Goldman Sachs, GE Healthcare, Becton Dickinson, and
many more, BioInformant is your global leader in stem cell
industry data.
For more about our company and clients, visit
www.BioInformant.com.
BioInformant Worldwide, LLC
BioInformant.com