ACTIVE CONSTITUENT OF DRUGS USED IN DIABETIC THERAPY, GYMNEMA SYLVESTRE, GYMNEMIC ACID, SALACIA RETICULATE, CHEMICAL CONSTITUENT, MECHANISM OF ACTION, USES.
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ACTIVE CONSTITUENT OF DRUGS USED IN DIABETIC THERAPY
1. ACTIVE CONSTITUENT
OF
DRUGS USED IN DIABETIC THERAPY
Presented by,
ASWINI SASIDHARAN
DEPT. OF PHARMACEUTICAL CHEMISTRY
GRACE COLLEGE OF PHARMACY, PALAKKAD
2. DIABETIC THERAPY
• Diabetes is a heterogeneous group of syndromes.
• Characterized by elevated blood glucose or absolute deficiency
of insulin.
3. Gymnema Sylvestre [milk weeds]
• Family - Apocynaceae.
• Biological Source - Obtained from the leaf,
root, stem & flower of the
Gymnema plant.
- Perennial woody wine
native to Asia, Africa &
Australia.
4. CHEMICAL CONSTITUENTS
• Contain Triterpene saponins belonging to Oleanane
and Dammarane classes.
• Oleanane saponins are:
1. Gymnemic acid
2.Gymnemagasaponin
Gymnemic acid
Gymnemagasaponin
7. Mechanism Of Action- Gymnemic acid
There are some possible mechanisms by which the leaves and especially
Gymnemic acids from G. sylvestre exert its hypoglycemic effects are:
• It increases secretion of insulin.
• It promotes regeneration of islet cells.
• It increases utilization of glucose.
• It causes inhibition of glucose absorption from intestine.
8. Uses
• Used in treatment of blood pressure.
• Used for weight loss.
• Lowering serum cholestrol and triglycerides.
• Decreasing Glycosylated haemoglobin.
• Used in glycosuria.
• anti inflammatory, anti helminthes, expectorant and snake bites.
9. Salacia Reticulate
• Family - Celastraceae.
• Biological Source - Obtained from the
bark, leaf, flower & fruit
of the plant Salacia.
- Native to Srilanka &
Andaman Islands.
13. Other Uses
• Used as an anti-inflammatory agent.
• Treatment of asthma.
• Treatment of Amenorrhea.
• Treatment of Rheumatism.
• Treatment of Dysmenorrhea.
