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UGI REACTION: A MULTI-COMPONENT REACTION
1. AMITY INSTITUTE OF PHARMACY
UGI REACTION
Submitted to Submitted by
Dr. Neerupma Dhiman Firuj Ahmed
Department of Pharmaceutical Chemistry Master of Pharmacy
1st Year
3. UGI REACTION:
A multi component reaction.
Multi Component reaction: A multi component reaction are those
reaction where three or more reactants come together in a single
reaction vessel to form a new product.
It is the most studied and used multi component reaction.
Ugi reaction takes place between a ketone or aldehyde, an amine, an
isocyanides and a carboxylic acid to form a bis amide.
Reported first by prof. Ivar Karl Ugi in the year 1959.
4. CHARACTERISTICS:
1.It is exothermic reaction.
2.Usually completes in minutes after isocyanide addition.
3.This is an uncatalyzed reaction.
4.Has high atom economy as only a molecule of water is lost.
5.High chemical yield.
10. SYNTHETIC APPLICATION OF THE UGI REACTION:
1.Synthesis of a synthetic opioid analgesic norsufentanil derivative: Fentanyl or fentanyl is a synthetic
opioid analgesic used as a pain medication to relieve pain after different treatments.
Novel substituted amino acid –tethered norsufentanil derivatives 2 were synthesized by Ugi reaction utilizing
the Carboxylic acid-tethered norsufentanil 1 with a variety of aldehydes, amines, and isocyanides to produce
a library of the desired norsufentanil derivatives compounds 2.
1 2
11. GENERAL APPLICATIONS:
1.It is used to develop chemical libraries.
2.It is used to synthesized a different number of compounds in
one reaction.
3.Crixivan(brand name for Indinavir) can be prepared by using ugi
reaction(used to treat HIV/AIDS)
4.Many of the caine-type anaesthetics are synthesized using this
reaction.
Ex– Lidocaine and Bupivacaine.
12. REFERENCE:
Boukis A.C., et al., “Multicomponent Reactions Provide Key
Molecules for Secret Communication”, Nature Communications,
2018, 9:1439.
https://www.organic-
chemistry.org/namedreactions/ugireaction.shtm
https://www.organic-reaction.com/organic-reaction/multi-
component-reactions/ugi-reaction/