The document summarizes brachial plexus anatomy and entrapment neuropathies of the upper limb. It describes the anatomy of the brachial plexus and its branches. It then discusses various entrapment neuropathies including carpal tunnel syndrome, anterior interosseous syndrome, pronator teres syndrome, cubital tunnel syndrome and others. For each neuropathy, it describes the anatomy, risk factors, clinical features, diagnostic tests and management approaches.
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Entrapment neuropathies
1. BRACHIAL PLEXUS ANATOMY AND ENTRAPMENT
NEUROPATHIES OF UPPER LIMB
Dr Ankit Kumar Garg
Moderator : Dr Md Zackariya Sir
2. Past Year DNB Questions
• Define entrapment syndrome. (June2018)
Enumerate various entrapment syndromes. (June2018)
• Anatomy & contents of carpal tunnel with suitable diagram(s). (June-2017)
Etiopathogenesis, clinical features. diagnosis and management of carpal tunnel
syndrome. (2+2+3+3) (Dec2015)
Clinical features and management of carpel tunnel syndrome.(6) (June2018)
Clinical features, diagnosis, treatment of Carpal tunnel syndrome. (2+2+2) (June
2015)
• Anterior Interosseous Nerve Syndrome(5) (June 2016-2B2), (5) (Dec 2013)
Enumerate its etiology and clinical features (4) (Dec 2017)
What are the diagnostic tests for it? (3) (Dec 2017)
Its treatment protocol? (3) (Dec 2017)
3. BRACHIAL PLEXUS
• The brachial plexus is a network of nerves formed by the union of
the anterior rami (branches) of C5 – C8 & T1 spinal nerves.
• It originates in the neck, passes laterally & inferiorly over the first
rib & enters the axilla.
• All major nerves of the upper limb originate from parts of the
brachial plexus
4. PREFIX / POST FIX
• C5 usually receives some fibers from C4, and T1 usually receives fibers from T2.
• The formation of the brachial plexus begins just distal to the scalene muscles.
6. Roots
• Long thoracic nerve (C5, C6, C7)- supplies serratus anterior
• Dorsal scapular nerve (C5)- supplies levator scapulae, rhomboidus major and minor
Trunks
• Suprascapular nerve(C5,C6)- branch of upper trunk; supplies supra and infraspinatus
• Nerve to subclavius(C5,C6)- Supplies subclavius
Division
No Branch
7. Branches of lateral cord (LML)
• Lateral pectoral n.(C5-C7)
• Pectoralis major and minor
• Musculocutaneous n.(C5-C7)
• Biceps
• Brachialis
• Coracobrachialis
• Lateral root of median nerve(C5-C7)
8. Branches of medial cord (M4U)
• Medial pectoral nerve(C8,T1)-sternoclavicular
head of pectoralis major
• Medial cutaneous nerve of arm(C8,T1)
• Medial cutaneous nerve of forearm
• Medial root of median nerve(C8,T1)
• Ulnar nerve(C7,C8,T1)
9. Branches from Posterior cord (ULNAR)
• Upper subscapular nerves(C5,C6)
• Lower subscapular nerves
supply subscapularis and teres major
• Nerve to Latissimus dorsi. (C6,C7,C8)
(thoracodorsal nerve)
• Axillary nerve(C5,C6)
• teres minor
• deltoid muscles
• patch of skin over deltoid
• Radial nerve(C5-C8,T1)
• continuity of posterior cord
11. Pathophysiology of compression neuropathies
• Hampers intraneural blood flow & transfer of oxygen and
micronutrients
Venous flow stops at 20-30 mm Hg
Frank ischemia at 60-80 mm Hg
Ischemia impairs myelination ; demyelination seen
• Direct injury to axons
• Interferes with axoplasmic flow- at 50 mm Hg, metabolites
distribution is disturbed, complete conduction block at 130 mm Hg
12. Median Nerve
• Root Valve : C5-T1
• Median Nerve : Flexor Digitorum Superficialis
Flexor Carpi Radialis Longus
Palmaris Longus
• Ain : Flexor Pollicis Longus
Fdp Of Index , Middle Finger
Pronator Quadratus
• Motor Branch: Thenar Muscles( Only Sup.Fpb)
Lateral 2 Lumbricals
19. Carpal tunnel pressure
• Normal – 2.5 mm Hg
• 20-30 mm Hg- reduces venule flow in epineurium, nerve oedema
• > 30 mm Hg- decreases nerve conduction
• In chronic CTS- higher compression needed to produce symptoms
20. Types of presentation
Acute onset
• Trauma,
• infection,
• Hematoma,
• Injections
Needs urgent decompression
Chronic
• MC idiopathic
• hypertrophy of fibrous tissue+ chronic
edema+ minimal inflammation of nerve
• MC site of compression 1cm distal to
proximal edge of ligament (thickest part)
• female predominant
21. FACTORS AFFECTING CARPAL TUNNEL
Anatomy
Decrease in Size of Carpal Tunnel
■ Bony abnormalities of the carpal bones
■ Acromegaly
■ Flexion or extension of wrist
Increase in Contents of Canal
■ Forearm and wrist fractures (Colles fracture, scaphoid
fracture)
■ Dislocations and subluxations (scaphoid rotary subluxation, lunate volar
dislocation)
■ Posttraumatic arthritis (osteophytes)
26. Diagnosis- mainly clinical
• “Nocturnal acroparesthesia”-
disturbs sleep
also in daytime by provocative
postures- keyboard, hyperflexion of
wrist, praying, sewing
• Bilateral common – 87%, but
mostly one side predominant
• Chronic cases- grip & pinch loss
• Autonomic dysfunction
• Thenar atrophy- very late
KATZ AND STIRRAT HAND DIAGRAMS
31. Investigations
Electrodiagnostic studies- NCV
• Sensitive in clinically silent
patients
• Rule out other causes
• Quantifies severity of damage,
and recovery
• In early irritative stage- false
negative due to excess
excitability & ectopic impulse
generation
Diagnostic criteria for CTS
• Sensory fiber compression- Delayed/
absent motor nerve sensory action
potential(SAP) >3.4ms latency
Increased median to ulnar latency
difference 4th finger SAP >0.5ms
• Motor fiber compression – Distal
motor latency >4.2ms.
Denervation signs in APB muscle
32. MRI
• Flattening of median nerve at hook of hamate level
• Cross sectional diameter ratio of median nv at level of pisiform : distal
radius – Normal is 1, Increases in CTS
• Inflammatory fluid
• Fatty infiltration
• Space occupying lesions
• Scarring
33. Management
• Non surgical Injections Surgical CTR including arthroscopy
• Poor outcome indicators
Diabetics
Workman compensation
No response to steroid injections and orthosis
Prolonged duration >3 years
Thenar atrophy
34. Non surgical
• 80 % respond to night wrist splinting and intermittent day
splinting
• Lowest pressure in 2 ± 9ᵒ extension and 2 ± 6ᵒ ulnar
deviation : keeps lumbricals out of tunnel
• Most helpful in Phalen positive
• NSAIDS, Pyridoxine, Methylcobalamine
• Oral steroids and diuretics for fluid retention
• Laser, UST,
35. • Starting point- 4th finger flexed
towards distal wrist crease
• Incision ulnar to thenar crease
and 2mm ulnar to 4th ray
• Keep dissection lateral to avoid
injury to thenar and palmar
cutaneous branch
• No internal neurolysis- leads to
neurodermodesis &
algoparesthesia
36. Surgical release
• Open Mini-open Endoscopic
• Endoscopic release allows earlier return to work and improved
strength during the early postoperative period.
• Results at 6 months or later were similar according to current data
except that patients with endoscopic release are at greater risk of
nerve injury and lower risk of scar tenderness compared with open
release.
38. • Pure motor
• AIN arises 4cm distal to medial
epicondyle
beneath the fibrous arch of FDS
• Descends on anterior aspect of
interosseous
membrane along with artery
• Between FDP and FPL
ANTERIOR INTEROSSEOUS SYNDROME
39. ENTRAPMENT SITES
• Between 2 heads of pronator
teres
• FDS arcade
• Edge of lacertus fibrosus
• Anomalous structures-
Supracondylar spur with
accessory bicipital aponeurosis
Gantzers muscle – accessory head
of FPL
Anomalous heads of PT
40. Clinical features
• Complete/ Incomplete
• Motor palsy
• Fatigue pain and dyskinesia
in proximal volar forearm
after repititve work
• Martin Gruber anastomosis-
incomplete palsy
41. Management
• EMG- FPL, index FDP, middle FDP, pronator quadratus
• Non operative
Splint in supination
Correct DM, hypothyroid, alcohol
Pyridoxine
• Operative
Failed conservative
Anatomical causes- spurs, SOL
44. • Between 2 heads of PT
• Females in 5th decade
• Males- atheletes, bodybuilders
• Fibrous bands between 2 heads
• Thickened or tight bicipital aponeurosis
(lacertus fibrosus)- lacertus fibrosus
syndrome in venepuncture/ exercise
• Supracondylar process + Ligament of
Struthers
• FDS aponeurotic arch
• Anomalous heads of PT
• Iatrogenic- tight casts
45. Clinical features
• Aching pain in volar proximal forearm aggravated by pronation, elbow flexion
• Paraesthesia's and hypesthesia's in median nv sensory distribution similar to CTS
• Tenderness on median nerve in proximal forearm
• Weakness of all muscles supplied by median nv
• Tinel's sign in proximal forearm- after 4-5 mths
• Resisted elbow flexion in supination – at bicipital aponeurosis
• Resisted pronation in elbow flexion- between 2 heads of PT
• Resisted middle finger FDS contraction- at FDS arch
• Pressure over pronator teres increases paraesthesia
• Associated medial epicondylitis
46. Carpal Tunnel Syndrome vs Pronator teres syndrome
CTS PTS
Forearm painfree Aching over proximal volar
forearm
Palmar cutaneous nerve
spared
Palmar cutaneous territory
affected
Night paresthesia Lack of night symptoms
Symptoms aggravate by wrist
hyperflexion
By forearm flexion and
repititive prono-supination
47. Management
CTS PTS
• Nonoperative- successful in 50
%
• Rest, splinting and NSAIDs for
3- 6 months
• Avoid forearm pronation
• Operative-successful in 90 %
• Decompress all possible sites
48. ULNAR NERVE ( MUSICIAN NERVE)
• ROOT VALUE : C7,C8,T1
• MUSCLE SUPPLY : FLEXOR CARPI ULNARIS
FLEXOR DIGITORUM PROFUNDUS
4 PALMAR + 4 DORSAL INTEROSSEI
MEDIAL 2 LUMBRICALS
HYOTHENAR MUSCLES
ADDUCTOR POLLICIS
DEEP HEAD OF FLEXOR POLLICIS BREVIS
51. • 55 % cross sectional area reduction in flexion
• Olecranon advances 5 mm / 45ᵒ flexion
• Elongation stretch of 47 mm in flexion
• Pressure 9mm Hg to 63 mm Hg, + FCU contraction= 209 mm Hg
52. Common sites of compression
• Between 2 heads of FCU/ aponeurosis- Most
common
• Arcade of Struthers- 70 % incidence; 8-10 cm
prox to medial epicondyle; medial head
triceps medial intermuscular septum
• Hiatus in medial intermuscular septum
• Between Osborne ligament and MCL
• Medial head triceps
• Anconeus epitrochlearis- medial olecranon
medial epicondyle
• Fractures, malunions, Cubitus varus/valgus,
Tardy ulnar palsy
• Osteophytes, myositis ossificans
• Tumors, cysts, medial epicondylitis
• Iatrogenic- Intercondylar fixations, Radial
head excision
53.
54. Clinical features
• Ulnar paresthesia on elbow flexion
• Involvement of ulnar dorsal hand
rules out Guyon canal involvement
• Night symptoms due to elbow flexion
• Atrophy of 1st webspace and
interossei
• Ulnar clawing
• Weak grasp- loss of MCP flexion
• Weak pinch- 70 % loss due to
adductor pollicis
57. • Tinel's sign over cubital tunnel
• Elbow flexion X 60 s
• Compression on cubital tunnel
• EMG- adductor policis, FCU
• Non operative management
Night splint in extension and
neutral rotation
• Operative
In-situ decompression
Anterior transposition
Medial epicondylectomy
58. Cubital tunnel decompression
Medial incision 5-10 cm long
Avoid too proximal release- causes ulnar
subluxation
Release all possible entrapping structures
Best results in compression restricted to Osborne
fascia
Poor results
Presence of muscle atrophy (chronic)
Compression secondary to elbow deformity
Compression by tumours and cyst
59. Ulnar nerve decompression and anterior
transposition
Indications
• Failed in situ release
• Intractable long standing neuritis
• Throwing athlete
• Metabolic/ Granulomatous
neuropathy
• ORIF of intra-articular fractures
• Elbow reconstruction &
arthroplasty
Types of ulnar nerve transposition
• Subcutaneous
• Submuscular
• Intramuscular
64. Etiology
Anatomical
• Ganglion cyst- Most common
nontraumatic cause
• Lipoma/ Neurilemmoma
• Fibrous bands
• Pisiform – hamate coalition
• Accessory FDM, palmaris brevis
or palmaris longus
Traumatic
• Nonunion or # hook of hamate
• Handlebar palsy
• Pisiform dislocation
Systemic
• Diabetes
• Alcoholism
• Hypothyroid
Hypothenar hammer syndrome-
ulnar artery thrombosis
Calcinosis
PVNS
65. Clinical features
• Pure motor
• Pure sensory
• Mixed
• Wrist pain and ulnar
paresthesias/ numbness
• Ulnar clawing
• Intrinsic paralysis
• Weak grasp and pinch
• Froment sign
• Bunnel O sign
• Scratch collapse test
66. Diagnosis
• Plain Xray
• MRI
Main DD- Cubital tunnel syndrome
• Less clawing- long flexor involve
• Positive elbow flexion test
• Motor deficit in FDP, FCU
• Sensory deficit in ulnar dorsum
of hand
• Tinels positive at elbow
67. Treatment
Non operative
Operative
• For clawing
• Loss of grasp and pinch
• Local decompression incision in
line radial aspect 4th digit
• Done sequentially zone 123
• Tendon transfers- for claw
• Lasso procedure- use FDS 4 or
ECRB
68. RADIAL NERVE
• ROOT VALVE (C5-C8,T1)
• MUSCLE SUPPLY : BSG- LONG & MED. HEAD OF TRICEPS
SG - LATERAL HEAD & ANCONEUS
ASG- BRACHIALIS,BR,ECRL
• PIN MUSCLE SUPPLY:ECRB,SUPINATOR,ED,EDM,ECU
APL,EPB,EPL,EXTENSOR INDICIS
70. • Combined sensory motor
• Just after radial nerve splits into
PIN and RSN
• Not a true compressive
neuropathy because
Prominent focal tenderness
Normal neurology
No confirmatory EMG
• Medial wall- Brachialis, biceps
tendon
• Lateral wall & roof- ECRL, ECRB,
EDC
• Floor- Capsule of radiocapitellar
joint
71.
72. Sites of compression
5 potential sites
• Between brachialis and BCR
• Leash of Henry
• Origin of ECRB
• Arcade of Frohse
• Distal edge of supinator
73. Etiology of compression
• Repetitive prono-supination
• Monteggia/ radial head fractures
• Space occupying lesions
• Rheumatoid synovitis of radio-capitellar joint
• Iatrogenic
74. Clinical features
• Pain in forearm and wrist
• Night pain
• Pronation and wrist extension aggravates the pain
• Motor weakness
• Weakness of wrist extension in ulnar deviation- ECU
• Painful resisted supination- arcade of Frohse
• Painful resisted middle finger extension- ECRB and BR
75. Treatment
• Non operative- wrist splinting in
15ᵒ extension ± elbow flexion
• Avoid provocative activities
• UST, Cryotherapy
• Stretching ex
• Local steroid injections
• Operative-
Resistant cases
Compression by mass detected on
MRI
Anterior approach between
brachioradialis and biceps tendon
Posterior approach between ECRB
and EDC or BR and ECRL
All possible sites are
decompressed
77. Cheiralgia paresthetica/ Handcuff neuropathy/
Wristwatch neuritis
• Pure sensory – RSN involvement
• During pronation, scissoring
between BR and ECRL is main
cause
• Fascial bands
• Trauma
• Anatomic variations in BR
• Lipoma
• Diabetes
78. Clinical features
• History of handcuff or tight
wristwatch use
• Ill defined pain over dorsoradial
hand
• Avoids wearing watch
• Paresthesia in dorsal hand
radially aggravates by wrist
flexion and ulnar deviation
• Tinel's sign over wrist radial
styloid
• Dellon’s provocative test- wrist
flexion, ulnar deviation and
pronation X 1 min
• Finkelstein test +ve in 95 % due
to traction on RSN
84. • Mixed nerve, c5-c6 roots
• Passes under omohyoid and
anterior border of trapezius to
reach suprascapular notch
85. Etiology
• Trauma- direct injury to Erbs point, scapula #, malunion
• Traction- volleyball players, scapular instability
• Entrapment under scapular notch- ganglions, lipoma, synovial
sarcoma, Ewings sarcoma or in spinoglenoid notch by ganglion
cysts
Clinical features
• Vague pain in posterolateral aspect of shoulder radiates across
scapula
• Paresthesia and burning pain
• Pain brought about by crossbody adduction and external rotation
• Supraspinatus and infraspinatus atrophy in chronic
86. • Pure motor type seen in professional volleyball players , involvement at
spinoglenoid notch and spares the sensory branch
• Scapular dyskinesia
Investigations
• MRI
• EMG
Treatment
Conservative:
• Steroid injections
• Scapular stabiliser strengthening exercises
• Restrict overhead strenuous activities
87. Surgical management
• Removal of underlying pathology
• Posterior Swafford and Lichtman approach- oblique incision along
spine of scapula
• Trapezius elevated subperiosteally
89. superior - subscapularis and teres minor
inferior - teres major
medial - long head of triceps brachii
lateral - surgical neck of the humerus
QUADRILATERAL SPACE SYNDROME
90. Etiology of compression
Compression and reduction of
quadrangular space due to
• Tight fibrous bands, muscular
hypertrophy
• Paralabral cysts (most commonly
inferior labral tears)
• Trauma (scapular fracture,
shoulder dislocation)
• Benign or malignant masses
Pathomechanics
• greatest amount of compression
occurs when the arm is positioned
in the late cocking phase of
throwing (abduction and external
rotation)
91. Clinical features
• 20-40 year age
• Dominant shoulder
• Throwing atheletes- basketball, volleyball
• Poorly localized pain of the posterior/lateral shoulder
• Often worse at night
• Worse with overhead activity or late cocking/acceleration phase of throwing
• Non-dermatomal distribution of paraesthesia along the lateral shoulder and
arm
• Shoulder external rotation weakness
92. • Atrophy of the teres minor and deltoid (chronic)
• Point tenderness over the quadrangular space
• External rotation weakness with the arm abducted in throwing position
• Pain exacerbated by active and resisted abduction and external rotation
of the arm
Neurological examination
• usually normal
• have mild sensory changes in the axillary nerve distribution
93. Investigations
Xrays- shoulder series (AP, lateral, axillary
views)
• usually normal
• used to rule out pathologic entities
MRI
• often used to rule out rotator cuff
pathology
• may show atrophy of teres minor (axillary
innervation)
• may show compression of the
quadrilateral space
• may show inferior paralabral cyst
associated with labral tear
Arteriogram
• may shows lesion in posterior humeral
circumflex artery
EMG
• used to confirm diagnosis
• will show axillary nerve involvement
94. Treatment
Non operative
NSAIDS, activity restriction, physiotherapy
• glenohumeral joint mobilization and strengthening
• posterior capsule stretching
• massage
• most people improve with 3-6 months of nonoperative treatment
Operative- open release of quadrilateral space +/- arthroscopic repair of labral tear
• failure of nonoperative management
• significant weakness and functional disability
• decompression of space-occupying lesion
Accompanies brachial artery in the arm, crossing it during its course (lateral to medial) approximately 15 cm from the medial epicondyle
Supplies some branches to the elbow joint but has no branches in the arm itself
Medial to brachial artery and superficial to brachialis muscle as it passes
In forearm, the median nerve splits the two heads of the pronator teres and then runs between the FDS and FDP. Supplies all the superficial flexor muscles of the forearm except the FCU.
Anterior interosseous nerve branches 4 cm distal to elbow and runs between the FPL and FDP, supplies all the deep flexors except the ulnar half of the FDP. Terminates in the pronator quadratus (PQ).
Palmar cutaneous branch arises approximately6 cm proximal to radial styloid and passes superficial to the flexor retinaculum to innervate the thenar skin.
Median nerve passes through the carpal tunnel between FDS and flexor carpi radialis (FCR) to supply the radial lumbricals, thenar musculature via a deep recurrent branch, and sensation to the volar aspect of thumb, index, long, and radial half of the ring fingers.
Accompanies brachial artery in the arm, crossing it during its course (lateral to medial) approximately 15 cm from the medial epicondyle
Supplies some branches to the elbow joint but has no branches in the arm itself
Medial to brachial artery and superficial to brachialis muscle as it passes
In forearm, the median nerve splits the two heads of the pronator teres and then runs between the FDS and FDP. Supplies all the superficial flexor muscles of the forearm except the FCU.
Anterior interosseous nerve branches 4 cm distal to elbow and runs between the FPL and FDP, supplies all the deep flexors except the ulnar half of the FDP. Terminates in the pronator quadratus (PQ).
Palmar cutaneous branch arises approximately6 cm proximal to radial styloid and passes superficial to the flexor retinaculum to innervate the thenar skin.
Median nerve passes through the carpal tunnel between FDS and flexor carpi radialis (FCR) to supply the radial lumbricals, thenar musculature via a deep recurrent branch, and sensation to the volar aspect of thumb, index, long, and radial half of the ring fingers.
Accompanies brachial artery in the arm, crossing it during its course (lateral to medial) approximately 15 cm from the medial epicondyle
Supplies some branches to the elbow joint but has no branches in the arm itself
Medial to brachial artery and superficial to brachialis muscle as it passes
In forearm, the median nerve splits the two heads of the pronator teres and then runs between the FDS and FDP. Supplies all the superficial flexor muscles of the forearm except the FCU.
Anterior interosseous nerve branches 4 cm distal to elbow and runs between the FPL and FDP, supplies all the deep flexors except the ulnar half of the FDP. Terminates in the pronator quadratus (PQ).
Palmar cutaneous branch arises approximately6 cm proximal to radial styloid and passes superficial to the flexor retinaculum to innervate the thenar skin.
Median nerve passes through the carpal tunnel between FDS and flexor carpi radialis (FCR) to supply the radial lumbricals, thenar musculature via a deep recurrent branch, and sensation to the volar aspect of thumb, index, long, and radial half of the ring fingers.
Accompanies brachial artery in the arm, crossing it during its course (lateral to medial) approximately 15 cm from the medial epicondyle
Supplies some branches to the elbow joint but has no branches in the arm itself
Medial to brachial artery and superficial to brachialis muscle as it passes
In forearm, the median nerve splits the two heads of the pronator teres and then runs between the FDS and FDP. Supplies all the superficial flexor muscles of the forearm except the FCU.
Anterior interosseous nerve branches 4 cm distal to elbow and runs between the FPL and FDP, supplies all the deep flexors except the ulnar half of the FDP. Terminates in the pronator quadratus (PQ).
Palmar cutaneous branch arises approximately6 cm proximal to radial styloid and passes superficial to the flexor retinaculum to innervate the thenar skin.
Median nerve passes through the carpal tunnel between FDS and flexor carpi radialis (FCR) to supply the radial lumbricals, thenar musculature via a deep recurrent branch, and sensation to the volar aspect of thumb, index, long, and radial half of the ring fingers.
Accompanies brachial artery in the arm, crossing it during its course (lateral to medial) approximately 15 cm from the medial epicondyle
Supplies some branches to the elbow joint but has no branches in the arm itself
Medial to brachial artery and superficial to brachialis muscle as it passes
In forearm, the median nerve splits the two heads of the pronator teres and then runs between the FDS and FDP. Supplies all the superficial flexor muscles of the forearm except the FCU.
Anterior interosseous nerve branches 4 cm distal to elbow and runs between the FPL and FDP, supplies all the deep flexors except the ulnar half of the FDP. Terminates in the pronator quadratus (PQ).
Palmar cutaneous branch arises approximately6 cm proximal to radial styloid and passes superficial to the flexor retinaculum to innervate the thenar skin.
Median nerve passes through the carpal tunnel between FDS and flexor carpi radialis (FCR) to supply the radial lumbricals, thenar musculature via a deep recurrent branch, and sensation to the volar aspect of thumb, index, long, and radial half of the ring fingers.