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1. GURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE AND
TECHNOLOGY
TOPIC : Overview about Mass Transfer Coefficient
NAME OF THE STUDENT : ANKIT GHOSH
UNIVERSITY ROLL NUMBER : 31308421036
ACADEMIC SESSION : 2023-24
PAPER NAME : INDUSTRIAL MICROBIOLOGY
PAPER CODE : CMc 502
Maulana Abul Kalam Azad University of Technology

2. B. Sc./ SEM 5/2023-2/ / INDUSTRIAL MICROBIOLOGY / CMc 502 /Presentation_1
• Mass transfer may occur in a gas mixture, a liquid solution or
solid.
• Movement of the molecule occurs due to concentration gradient
known as molecular diffusion
• The basic mechanisms are the same whether the phase is a gas,
liquid, or solid.
• The transfer of mass within a fluid mixture or across a phase
boundary is a process that plays a major role in many industrial
process.
INTRODUCTION

3. B. Sc./ SEM 5/2023-24 / INDUSTRIAL MICROBIOLOGY / CMc 502 /Presentation_1
Mass Transfer Coefficient
The mass transfer coefficient is a diffusion rate constant that relates the mass transfer rate,
mass transfer area, and concentration change as driving force
Where:
• is the mass transfer coefficient [m/s]
• is the mass transfer rate [mol/s]
• is the effective mass transfer area [m2]
• is the driving force concentration difference [mol/m3]
The units will vary based upon which units the driving force is expressed in. The driving force shown
here as is expressed in units of moles per unit of volume, but in some cases the driving force is
represented by other measures of concentration with different units.

4. B. Sc./ SEM 5/2023-24 / INDUSTRIAL MICROBIOLOGY / CMc 502 /Presentation_1
Quantifying mass transfer allows for design and manufacture of separation process equipment
that can meet specified requirements.
Mass transfer coefficients can be estimated from many different
theoretical equations, correlations, and analogies that are functions of material
properties, intensive properties and flow regime (laminar or turbulent flow).
This can be used to quantify the mass transfer between phases, immiscible and partially
miscible fluid mixtures (or between a fluid and a porous solid).
The volumetric mass transfer coefficient, (KLa) indicates the rate of oxygen used for
fermentation, taking into account all oxygen-consuming variables in the bioreactor.
The equations describing oxygen transfer are based on dissolved oxygen concentration.
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5. CONCLUSION
B. Sc./ SEM 5/2023-24 / INDUSTRIAL MICROBIOLOGY / CMc 502 /Presentation_1
The determination of the KLa value for fermentation is important in order to
maintain adequate transfer of oxygen in a bioreactor, for laboratory scale use or
when scaling up to a larger process
KLa values are used in scaling up from laboratory scale to pilot scale or
production scale bioreactors
The determination of the KLa of a fermenter is essential in order.
The equations describing oxygen transfer are based on dissolved oxygen
concentration
The solubility of oxygen is affected by dissolved solutes therefore pure water and
a fermentation medium saturated with oxygen have different dissolved oxygen
concentrations

6. B. Sc./ SEM 5 /2023-24 / INDUSTRIAL MICROBIOLOGY / CMc 502 /Presentation_1
REFERENCE
• Welty, James R.; Wicks, Charles E.; Wilson, Robert Elliott (1976). Fundamentals of
momentum, heat, and mass transfer (2 ed.). Wiley. ISBN 9780471022497.
• Seader, J. D.; Henley, Ernest J. (23 January 1998). Separation Process Principles. New
York: Wiley. ISBN 0-471-58626-9.