Transaminases or aminotransferases are enzymes that catalyze a transamination reaction between an amino acid and an α-keto acid. They are important in the synthesis of amino acids, which form proteins

1. Aminotransferases
- Alex Thomas
02.06.2018
Basics

2. Do you Know?
• What is meant by transamination?
• What is the relation between AST, ALT, 1954 and Arthur Karmen?
• Why the name serum glutamic oxaloacetic transaminase?
• Why the name serum glutamate-pyruvate transaminase

3. Transamination
 Transfers an amino group to a ketoacid to form a new amino acid
Transaminases
Amino acid
Amino acidKeto acid
Keto acid

4. Aspartate transaminase (serum glutamic oxaloacetic transaminase)
• Arthur Karmen (1954)
AST
Glutamate
Oxaloacetate
α-Ketoglutarate
Aspartate

5. Alanine transaminase ( serum glutamate-pyruvate transaminase)
ALT
Glutamate
Pyruvate α-Ketoglutarate Alanine

6. Other Transaminases
 Cysteine transaminase
 Glycine transaminase
 Tyrosine transaminase
 Leucine transaminase
 Kynurenine--oxoglutarate transaminase
 2,5-diaminovalerate transaminase
 Histidinol-phosphate transaminase
 Acetylornithine transaminase
 Alanine--oxo-acid transaminase
 Ornithine aminotransferase
 Asparagine--oxo-acid transaminase
 Glutamine--pyruvate transaminase
 Glutamine--fructose-6-phosphate transaminase (isomerizing)
 Succinyldiaminopimelate transaminase
 Beta-alanine--pyruvate transaminase and many more

7. Thank You