Chronic Fatique Syndrome

1. CHRONIC FATIQUE
SYNDROME
Ade Wijaya, MD – June 2021

2. Introduction
 Chronic Fatique Syndrome (CFS) = Myalgic
encephalomyelitis
 Definition: a disabling clinical condition
characterized by unexplained and persistent
post exertional fatigue accompanied by a
variety of symptoms related to cognitive,
immunological, endocrinological, and
autonomous dysfunction
 Prevalence: 0.1 – 0.5 %
 Burden for patients and caregivers  public
health problems
Cortes Rivera M, Mastronardi C, Silva-Aldana CT, Arcos-Burgos M, Lidbury BA. Myalgic encephalomyelitis/chronic fatigue syndrome: a comprehensive review. Diagnostics.

3. Pillars of CFS
Cortes Rivera M, Mastronardi C, Silva-Aldana CT, Arcos-Burgos M, Lidbury BA. Myalgic encephalomyelitis/chronic fatigue syndrome: a comprehensive review. Diagnostics.

4. Clinical Manifestation
Cortes Rivera M, Mastronardi C, Silva-Aldana CT, Arcos-Burgos M, Lidbury BA. Myalgic encephalomyelitis/chronic fatigue syndrome: a comprehensive review. Diagnostics.

5. Etiology
 Viral infections
 Immune system problems
 Hormonal imbalances
 Physical and emotional trauma

6. Risk Factors
 Young and middle age
 Female

7. Pathophysiology
 Immune system
 Inflammation and oxidative stress
 NK alteration
 Immunoglobulins
 Autoimmunity
 Genetics
Cortes Rivera M, Mastronardi C, Silva-Aldana CT, Arcos-Burgos M, Lidbury BA. Myalgic encephalomyelitis/chronic fatigue syndrome: a comprehensive review. Diagnostics.

8. CNS Pathophysiology
 Neuroinflammation
 Neuronal sensitization
 Glial activation
 Alterations of Serotonin Transmission
 Neuroendocrine
 Hypocortisolism
Cortes Rivera M, Mastronardi C, Silva-Aldana CT, Arcos-Burgos M, Lidbury BA. Myalgic encephalomyelitis/chronic fatigue syndrome: a comprehensive review. Diagnostics.

9. Treatment
Cortes Rivera M, Mastronardi C, Silva-Aldana CT, Arcos-Burgos M, Lidbury BA. Myalgic encephalomyelitis/chronic fatigue syndrome: a comprehensive review. Diagnostics.

10. Summary
 CNS, Immune, endocrin
 Burden for patients and caregivers  public
health problems
 Prognosis: variable

11. THANK YOU