Nanotechnology is a dynamic and multi-disciplinary field here is the well explained PPT by Ashwini Sonawane from AISSMS College Of Pharmacy which is best pharmacy college in Pune.

1. RECENT ADVANCES
IN
NANOTHERAPEUTICS

2. Recent advances
in
Nanotherapeutics
Presented by: Ashwini Sonawane
M Pharm (SY- Pharmaceutics)
Guided by: Dr. Monica RP Rao
Department of Pharmaceutics
AISSMS COLLEGE OF PHARMACY

3. Introduction
• Nanotechnology is a dynamic and multi-disciplinary field
• Profound impact on drug delivery, diagnostics, nutraceuticals
• Tiny particles 5-200 nanometers (nm)
• Site specific and targeted drug delivery

4. Types of nanostructures
• Self assembled : Liposomes , polymeric micelles
• Superparamagnetic nanostructures
• Gold nanoparticles
• Solid lipid nanoparticles
• Polymeric nanoparticles
• Aptamers
• Quantum dots

6. Liposomes
• Artificially constructed vesicles consisting of the phospholipid bilayer.
• Ability to trap both hydrophobic and hydrophilic compounds.
• Liposomal encapsulation of drug and protein shows improved drug efficacy.
• E.g. Rifampicin and protein to improve antimicrobial efficiency.
• Applications: cardiovascular & neurodegenerative diseases, diabetes, cancer.
• Many applications in pulmonary drug delivery system.

7. Polymeric micelles
• Amphiphilic molecules or copolymers.
• Organized core structure in aqueous media above Critical Micelle Concentration.
• Ability to entrap hydrophobic drugs
• Achieve site-specific delivery and enhance their bioavailability.
• Promising drug delivery platform for ocular diseases of posterior segments.
• Age-related macular degeneration, diabetic retinopathy, and glaucoma.
• Applications in gene delivery and diagnostic imaging.

8. Superparamagnetic nanoparticles
• Superparamagnetic iron oxide nanoparticles (SPIONs) consisting of iron oxide core with
paramagnetic properties
• Guided to target area within our body through external magnets.
• Applications from diagnosis to advanced cancer therapy, magnetic fluid hyperthermia,
magnetic drug targeting, and theranostics.
• Some of the toxicological aspects associated with SPIONs are
• Protein aggregation due to iron accumulation,
• Oxidative stress,
• Altered cellular responses.

9. Gold nanoparticles
• Gold core which is typically surrounded by organic monolayer.
• Nanostructures such as nanoshells, nanorods, and nanocages
• Used for photo thermal ablation of cancer cells with near-infrared light without
damaging normal human tissues.
• Multifunctional coated gold nanoshells used for examination of head and neck cancers.
• Antioxidant properties
• Promising candidates for skin immunization and transdermal delivery system.

10. Aptamers
• Well-defined, folded, three dimensional structures.
• Small single-stranded nucleic acids.
• Intracellular, extracellular and cell surface targeting.
• Mucin1 (MUC1) aptamer-Dox conjugates for lung cancer targeting
• Prostate specific membrane antigen (PSMA) aptamer-doxorubicin conjugates for
prostate cancer targeting.

11. Quantum dots
• Fluorescent, inorganic, semiconductor nanoparticles
• Diameter 2-10 nm.
• Carbon dots or C-dots emerging as versatile nanomaterials.
• Used to image cancer cells due to superior fluorescent properties.
• Chitosan encapsulated zinc oxide quantum dots formulated for tumor targeting.

12. FDA approved nanomedicine
Technology Formulation Name of the
Product
Company Approval year
Liposome Vincristine Marqibo® Onco TCS 2012
Polymeric
Micelles
Estradiol Protein
NPs.
Estrasorb™ Novavax 2003
SPION Dextran Feridex®/
Endoderm®
Endoderm®
AMAG
2008
Gold
Nanoparticles
Silica nanoparticle
with gold shell
AuroShell® Nanospectra
Bioscience
2012

13. THANK YOU
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