Holobiome final presentation 7

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  • 7/31/13-Shoko edits in red
  • 7/31/13-Shoko edits in red
  • 7/31/13-Shoko edits in red
  • 7/31/13-Shoko edits in red
  • 7/31/13-Shoko edits in red

Transcript

  • 1. HOLOBIOME [Dx.3] Holobiome Envisioning a healthy microbiome for everyone 1.4 Million IBD patients Mild/Moderate patients Internet access
  • 2. HOLOBIOME Holobiome Kei Fujimura Post-doc at UCSF, Microbial ecologist Picker/Hustler Shoko Iwai Post-doc at UCSF, Microbial ecologist, Bioinformatics Hacker/Hustler Yosuke Kamimura Post-doc at UCSF, Immunologist, Virologist Designer/Hustler David Hanzel Diagnostics expert Mentor Envisioning a healthy microbiome for everyone
  • 3. IBD patients Physicians Week 1 Joint venture with Metabolon, who will provide metabolomic data. Buyer / suppliers: Illumina, MoBio . • Generate personalized baseline reports and track changes over time. • Online lifestyle diary to track effects of meds and diet on biome over time Physician organizations: Inflammatory Bowel Disase Center @ UCSF CPMC Research Institute Patient organizations and patient advocates: Crohns & Colitis Foundation Fixed costs: • Lab space and/or office space • Salaries • Server • Website maintenance • Lab equipment • Access to sample processing equipment (e.g. thermocycler, sequencer, biosafety cabinet) and lab technician or outsource all lab work • Computers / servers • Pipelines • Data analysts Sample processing: • Sample processing kits • Stool collection kits • Risk reduction for patients and physicians • Provide personalized prognositic for IBD patients in order to subvert flares and foresee colorectal cancer symptoms. • Reduce risk of misdiagnsosis and time through a noninvasive and safe diagnostic tool. • value-driven • Variable costs based on service levels • • Dedicated personal assistance Online community Personal physicians • Dedicated e-commerce • Direct sales. • Posts by patient advocates on Crohns & Colitis Foundation forums, patientslikeme.com, etc. • Web account and app • Seminars led by local thought leaders • MD to MD connections • Subscription fee (multiple samples) • Batch ordering for physicians • Fixed menu pricing. • Inflammatory Bowel Disease (IBD) Patients • General practice MDs, DOs, Gastroenterologists, Naturopaths
  • 4. IBD patients Physicians Week 1 Joint venture with Metabolon, who will provide metabolomic data. . • Generate personalized baseline reports and track changes over time. • Online lifestyle diary to track effects of meds and diet on biome over time • • • Dedicated personal assistance Online community Personal physicians VP CS Risk reduction for patients and •• Dedicated e-commerce Direct sales. • Inflammatory Buyer / suppliers: Illumina, physicians MoBio Bowel Disease • Provide personalized prognositic for Physician organizations: (IBD) Patients Inflammatory Bowel Disase IBD patients in order to subvert flares Center @ UCSF and foresee colorectal cancer CPMC Research Institute • Posts by patient symptoms. • General practice • Access to sample Patient organizations and patient advocates: Crohns & Colitis Foundation Fixed costs: • Lab space and/or office space • Salaries • Server • Website maintenance • Lab equipment processing equipment (e.g. thermocycler, sequencer, biosafety cabinet) and lab technician or outsource all lab work • Computers / servers • Pipelines • Data analysts advocates on Crohns & Colitis Foundation forums, patientslikeme.com, etc. • Web account and app MDs, DOs, Gastroenterologi sts, Naturopaths • Reduce risk of misdiagnsosis and time through a non-invasive and safe diagnostic tool. • Seminars led by local Sample processing: • Sample processing kits • Stool collection kits • value-driven • Variable costs based on service levels thought leaders • MD to MD connections • Subscription fee (multiple samples) • Batch ordering for physicians • Fixed menu pricing.
  • 5. Week 1-4: Our products were not ready for doctors and unnecessary for IBD patients Our Hypothesis Patients and doctors want the patients’ gut microbiome monitored in order to predict their next flares. What we found out… Interesting, but we need evidence. (19/19) I’m not interested. I want solutions, not another monitoring device! (5/7) -patient with mild or moderate IBD http://www.assetprotectionlawjournal.com/articles/physician-asset-protection/ http://www.cdc.gov/ibd/
  • 6. HOLOBIOME We were depressed……. Envisioning a healthy microbiome for everyone Explore other customer segments! Breakfast meeting
  • 7. Week 5: So then…we decided to include Joint venture with Metabolon, who will provide metabolomic data. Buyer / suppliers: Illumina, MoBio Validation that Risk reduction for their lifestyle patients and physicians reflects healthy Provide personalized gut •microbiome prognositic for IBD . • Generate personalized baseline reports and track changes over time. • Online lifestyle diary to track effects of meds and diet on biome over time • • Dedicated personal assistance Online community Personal physicians • Dedicated e-commerce • Direct sales. CPMC Research Institute • Access to sample processing equipment (e.g. thermocycler, sequencer, biosafety cabinet) and lab technician or outsource all lab work • Computers / servers • Pipelines • Data analysts • Reduce risk of misdiagnsosis and time through a noninvasive and safe diagnostic tool. • Posts by patient advocates on Crohns & Colitis Foundation forums, patientslikeme.com, etc. • Web account and app Sample processing: • Sample processing kits • Stool collection kits • value-driven • Variable costs based on service levels General practice MDs, DOs, Gastroenterolog ists, Naturopaths • Seminars led by local thought leaders • MD to MD connections http://www.9lot.com/2013/04/important-nutritionalproducts-needed-today.html Fixed costs: • Lab space and/or office space • Salaries • Server • Website maintenance • Lab equipment Health Inflammatory Bowel Disease conscious (IBD) Patients people patients in order to subvert flares and foresee colorectal cancer symptoms. Physician organizations: Inflammatory Bowel Disase Center @ UCSF Patient organizations and patient advocates: Crohns & Colitis Foundation • IBD patients Physicians Health conscious people • Subscription fee (multiple samples) • Batch ordering for physicians • Fixed menu pricing.
  • 8. HOLOBIOME Week 5: Health conscious people were not interested Our Hypothesis Health conscious people may want to know gut microbiome as a marker for healthiness. Envisioning a healthy microbiome for everyone What we found out… I’m not interested. I feel great and have no GI issues. (8/8)
  • 9. Week 6: Switched to Quantified Selfies who love data about Inflammatory Joint venture with Metabolon, who will provide metabolomic data. Buyer / suppliers: Illumina, MoBio . • Generate personalized baseline reports and track changes over time. • Online lifestyle diary to track effects of meds and diet on biome over time CPMC Research Institute Fixed costs: • Lab space and/or office space • Salaries • Server • Website maintenance • Lab equipment Risk reduction for patients and physicians Quantify • Provide personalized microbiome as prognositic for IBD patients in a token oforder to subvert flares and foresee colorectal healthiness cancer symptoms. Physician organizations: Inflammatory Bowel Disase Center @ UCSF Patient organizations and patient advocates: Crohns & Colitis Foundation • • Access to sample processing equipment (e.g. thermocycler, sequencer, biosafety cabinet) and lab technician or outsource all lab work • Computers / servers • Pipelines • Data analysts Sample processing: • Sample processing kits • Stool collection kits • Reduce risk of misdiagnsosis and time through a noninvasive and safe diagnostic tool. • value-driven • Variable costs based on service levels • • Dedicated personal assistance Online community Personal physicians • Dedicated e-commerce • Direct sales. Bowel Disease (IBD) Patients Quantified Self practice General • Posts by patient advocates on Crohns & Colitis Foundation forums, patientslikeme.com, etc. • Web account and app • Seminars led by local thought leaders • MD to MD connections • Subscription fee (multiple samples) • Batch ordering for physicians • Fixed menu pricing. MDs, DOs, Gastroenterolog ists, Naturopaths
  • 10. Week 6: QS’s value propositions were too diverse Our Hypothesis Quantified self want to monitor their gut microbiome HOLOBIOME Envisioning a healthy microbiome for everyone I want to track… Diet (2/9) Exercise (2/9) Mood (1/9) Sleep cycle (2/9) Blood pressure (2/9) Ketones (1/9) Heart rate (1/9) Blood glucose levels (1/9) Weight (2/9) http://www.innovation-alliance.net/
  • 11. HOLOBIOME We got depressed again…… Back to square one… Envisioning a healthy microbiome for everyone Patients want to remain in remission ‘naturally’ without side effects
  • 12. HOLOBIOME Week 7: Provide specialized probiotics Envisioning a healthy microbiome for everyone
  • 13. Final canvas: Specialized probiotics for IBD patients Suppliers: Metabolon will provide metabolomic data. Suppliers: SeqWright will provide DNA isolation and sequencing. Suppliers: KLAIRE LABS will grow bacteria and formulate into pills FDA Fixed costs: • Lab space and/or office space • Salaries • Server and website maintenance Research and publish Online lifestyle diary to track effects of meds and diet on biome over time GET: Ads on patient foundation Remain in remission GET: Clinical and scientific presentation Cost savings GET: Dossier to medical director GET: KOLs of GI specialist KEEP: Dedicated personal assistance KEEP: Customer surveys HR: Bioinformatics & Data analysts Computers/servers Pipelines Patent Trade secret (probiotics composition) Finance: Research grants • Shipping and handling • Value-driven • Variable costs based on service levels Inflammatory Bowel Disease (IBD) Patients Insurance company GROW: Referrals Dedicated Ecommerce Direct Sales GI doctors prescribe probiotics Direct Sales Fixed menu pricing: $200/month Get our codes covered
  • 14. HOLOBIOME What we found out overall…. • IBD patients want solutions not another way to monitor. Envisioning a healthy microbiome for everyone • For our goals reflected in our mission statement, the science of using the microbiome is still ~ 5-10 years away.
  • 15. Our Investment Readiness Level 3. Product/Market Fit 2. Problem/Solution 1. Hypotheses (Canvas) • Now! Technology Readiness Level 1 & 2. Basic Technology Research • Research Company