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Dual function camera webinar presentation for webpage

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Whiteboard2Boardroom presents innovations from regional universities, hospitals, research organizations to encourage commercialization.

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Dual function camera webinar presentation for webpage

  1. 1. Dual Function Camera-cytology Device for Gastrointestinal Diagnosis & Imaging June 18, 2020
  2. 2. What is the problem? • By 2030, in many countries, 1 in 100 men may develop esophageal cancer (American Journal of Gastroenterology). • Rise in the prevalence of conditions affecting the upper gastrointestinal tract including • gastroesophageal reflux disease • Barrett’s esophagus • eosinophilic esophagitis • squamous dysplasia of the esophagus • Patients with gastroesophageal reflux disease (GERD) or Barrett’s esophagus have an increased risk of developing cancer of the esophagus and therefore must be monitored carefully. • The current protocol for biopsies of the esophagus only collects 5% of the esophageal mucosa. • There is a need for a low cost screening tool for these conditions that has the potential to reduce human suffering globally.
  3. 3. How does product solve problem? • Small camera/collection device that collects samples all along the surface of the esophagus, increasing disease detection rate. • Small (pill-sized) retractable capsule device containing a tiny balloon that can be inflated to project a set of integrated plastic strip brushes with medical grade nylon bristles. Once the balloon deflates, the sample is kept safely protected within the capsule. • The capsule also has a micro-CMOS camera attached to the front, which takes pictures of the esophagus as it travels down. The camera that is connected digitally to a computer to monitor and record live video. Prototypes in Development
  4. 4. How does product solve problem? • The present invention is designed to be portable and easy to perform by a nurse or health care worker (non-professional) during a regular patient visit. • Sedation and/or anesthesia are not expected to be necessary with use of this device. It reduces the – (1) the requirement for physical location (2) the need for a physician to perform the procedure (3) the inconvenience and secondary effects on patients Prototypes in Development
  5. 5. What is the market use? • Device features both camera and cytological “collectors” activated via pressurized air. The device allows direct visualization and tissue sampling of the esophagus and the stomach lining. • The functionality of the device is similar to an endoscope, but likely much less invasive with increase in detection rates • The procedure should not require sedation and can be done by a nurse or health care worker at a regular patient visit. • Unique “pneumatically activated cytology” demonstrates novel approach. Improves simplicity, safety, and patient comfort over other methods • In the case of cancer, this device can provide a minimally invasive method to monitor progression and/or regression of the disease throughout treatment.
  6. 6. What competition exists? • Dual functions – imaging and cell collection – combined in one device • The brushes that project from the balloon are conceivably an improvement over the current endoscopic tweezers and needles that are used to collect cells. • A broad collection of cells occurs with use of a brush, that reduces the sampling error significantly and therefore disease detection rates may be increased. • Polymer components drastically reduce costs allowing for a completely disposable device. Allows for broad utilization in low-income markets (Asia, Africa) • This procedure collects much more of the mucosa and increases chances of detecting cancer earlier and reduces sampling error. • Eliminates need for endoscopy in order to diagnose conditions affecting the upper gastrointestinal tract
  7. 7. What is the status of the intellectual property? United States Patent Application Publication # 20190387961 entitled “Imaging and Collection Device and Related Systems and Methods” filed January 31, 2017
  8. 8. What is the stage of development? Prototype of the device available and tested in vitro In vivo testing in animals is in progress
  9. 9. What is needed for further development? • Determine most effective “cell collector” design via further in vitro testing • Improve camera integration within custom parts (mounting, image quality. etc) • Address all safety concerns regarding class II FDA approvals • Develop relationships with vendors and suppliers to acquire parts/improve processes • Preliminary in vivo animal testing, refinement • Clinical trials
  10. 10. Questions?

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