Unit Presentation

1. PRESENTATION ON COMPLETE HEMOGRAM AND PERIPHERAL BLOOD SMEAR. Presenter: Dr.Tanoy Bose Moderator: Prof.R.K.Kotokey Department of Medicine, AMCH

11. PERIPHERAL BLOOD SMEAR Microangiopathic hemolytic anemia e.g. Severe burns DIC,TTP,Prosthetic valves Mechanical distortion Distended & fragmnted RBC Schistocyte Fe deficiency, Thalassemia RBC < 7.0 microns Microcyte Megaloblastic anemia (oval ) Liver disease (round ) Alcoholism Some Aplastic anemias MDS, Hydroxyurea Rx Young RBC Abnormal maturation RBC > 8.5 microns Well filled with Hb Macrocyte Fe def. anemia Thalassemia Sideroblastic Decreased hemoglobin synthesis Prominent central pallor Hypochromia Pb toxicity Thalassemia 5’ nucleotidase deficiency Precipitated ribosomes (RNA) Punctate basophilic inclusion Basophilic stippling Abetalipoproteinimia Parenchymal liver disease Post splenectomy. d/t altered membrane lipids Spiculated with dense core Acanthocytes

12. Contd………………. Myelopthesis Myelofibrosis Distorted , drop shaped cells Tear drop cells Liver disease,Post splenectomy, Thalassemia, Hemoglobinopathy Increased membrane redundancy Target like appearance, often hypochromic Target cells Hered. Spherocytosis Immunohemolytic anemia cl.Perfringiens toxin Decreased membrane redundancy Sperical c dense appearance & absent central pallor,usually of decreased diameter Spherocyte HbS disease ( not including trait) Molecular aggregation of HbS Bipolar,spiculated,pointed at both ends Sickle cell

14. THANK YOU