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Microelectrode Arrays for
   Retinal Prosthesis
    M. Tech. Project Presentation
             under the guidance of

             Prof. D K Sharma


                     By
          Dilawar Singh (07307011)
Objectives

• Fabrication of micro-electrodes arrays
  for retinal tissue characterization.
• Fabrication of micro-electrode arrays
  of needle like electrodes (for
  prosthesis).
Introduction
• Diseases like retinitis
  pigmentosa and AMD destroys
  the photo-receptors (rods and
  cones) but leaves the ganglion
  cells unharmed. These tissue
  can be electronically stimulated
  via microelectrodes arrays.
• Microelectrode with needle like
  stuctures are needed since they
  can penetrate the outer layer of
  the retina to reach the ganglion
  cells.




                                 source :
                                 internet.
Microelectrode arrays with
  needle like electrodes
• Needle length of about 5-10 um is desired so it
  can reach the randomly distribution ganglion
  cells.
• Needle were grown on Si and on Si-Oxide-
  polySi in HW-CVD by selective Liquid-vapor-
  Solid (LVS) growth method.
Fabrication Steps
• RCA cleaning of the wafer.
• Wet thermal oxidation (1-2 um).
• polySi deposition after oxidation
  in CVD; approximately 300 nm.
  Immediately given for
  lithography.
• Gold dots of 2, 4 and 10 um
  were deposited by liftoff method.
  DSA exposure was used.
• Needle grown in HW-CVD using
  VLS.
• Grass like growth seen.
Results: After the Au-liftoff




                                   Gold strip.

Peeling off of the gold dot when                 Gold dot 2 um after 2nd lifoff
liftoff is done just after the
deposition.                                      done
Liffoff showed nice results when                 2 days after Au-deposition.
done
after 2 days.
Results HW-CVD (1)




First sample : only flake were   Needle grown on
seen                             Si.
on the poly-Si. Perhaps due to
the
porous poly-Si deposition.
HW-CVD results (2)




Needle on the 4 um gold
dot.                           No growth seen on the gold dots. Needle
Si wafer without poly on it.   grown on
                               the gold-strip. No furthur experiment carried
                               out on
                               polySi.
HW-CVD results (3)




Needles grown on Gold strip.
Diameter approx is 0.25 um. Right side is the zoom in picture.
HW-CVD results (4)




Needles grown in 4 um Au dots arrays. Right hand side
Is the angular view of the single dot.
HW-CVD results (5)




Needle grown in 2 um diameter gold dot.
Right hand side shows the angular view.
Parameters used in various
      experiments
Results summaried
MEA with needles..
  proprosed fabrication plan
• Interconnects.
• Oxide deposited thermally
  and n+ doped after removing
  oxide from active region.
• CVD oxide layer. Etching of
  this layer and subsequent W
  wiring.
• Passivation oxide layer by
  CVD.
Mircroelectrode Array on
    ITO coated glass
              MEA geometry (CAD file)
              256 electrode with 6 um diameter.
              Average separation is 25 um.
Process steps
Results

          After ITO etching..
ITO -MEA

           ITO coated MEA.
           Without
            electroplating.
Simplified Retinal Model
Model Equations




The basic network of the retina: (1) is receptor cell, (2) is a
bipolar cell, (3) is a horizontal cell, (4) is a amacrine cell,
(5) is a ganglion cell, and f1 is the input.

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Towards Microelectrode Arrays for Retinal Prosthesis

  • 1. Microelectrode Arrays for Retinal Prosthesis M. Tech. Project Presentation under the guidance of Prof. D K Sharma By Dilawar Singh (07307011)
  • 2. Objectives • Fabrication of micro-electrodes arrays for retinal tissue characterization. • Fabrication of micro-electrode arrays of needle like electrodes (for prosthesis).
  • 3. Introduction • Diseases like retinitis pigmentosa and AMD destroys the photo-receptors (rods and cones) but leaves the ganglion cells unharmed. These tissue can be electronically stimulated via microelectrodes arrays. • Microelectrode with needle like stuctures are needed since they can penetrate the outer layer of the retina to reach the ganglion cells. source : internet.
  • 4. Microelectrode arrays with needle like electrodes • Needle length of about 5-10 um is desired so it can reach the randomly distribution ganglion cells. • Needle were grown on Si and on Si-Oxide- polySi in HW-CVD by selective Liquid-vapor- Solid (LVS) growth method.
  • 5. Fabrication Steps • RCA cleaning of the wafer. • Wet thermal oxidation (1-2 um). • polySi deposition after oxidation in CVD; approximately 300 nm. Immediately given for lithography. • Gold dots of 2, 4 and 10 um were deposited by liftoff method. DSA exposure was used. • Needle grown in HW-CVD using VLS. • Grass like growth seen.
  • 6. Results: After the Au-liftoff Gold strip. Peeling off of the gold dot when Gold dot 2 um after 2nd lifoff liftoff is done just after the deposition. done Liffoff showed nice results when 2 days after Au-deposition. done after 2 days.
  • 7. Results HW-CVD (1) First sample : only flake were Needle grown on seen Si. on the poly-Si. Perhaps due to the porous poly-Si deposition.
  • 8. HW-CVD results (2) Needle on the 4 um gold dot. No growth seen on the gold dots. Needle Si wafer without poly on it. grown on the gold-strip. No furthur experiment carried out on polySi.
  • 9. HW-CVD results (3) Needles grown on Gold strip. Diameter approx is 0.25 um. Right side is the zoom in picture.
  • 10. HW-CVD results (4) Needles grown in 4 um Au dots arrays. Right hand side Is the angular view of the single dot.
  • 11. HW-CVD results (5) Needle grown in 2 um diameter gold dot. Right hand side shows the angular view.
  • 12. Parameters used in various experiments
  • 14. MEA with needles.. proprosed fabrication plan • Interconnects. • Oxide deposited thermally and n+ doped after removing oxide from active region. • CVD oxide layer. Etching of this layer and subsequent W wiring. • Passivation oxide layer by CVD.
  • 15. Mircroelectrode Array on ITO coated glass MEA geometry (CAD file) 256 electrode with 6 um diameter. Average separation is 25 um.
  • 17. Results After ITO etching..
  • 18. ITO -MEA ITO coated MEA. Without electroplating.
  • 20. Model Equations The basic network of the retina: (1) is receptor cell, (2) is a bipolar cell, (3) is a horizontal cell, (4) is a amacrine cell, (5) is a ganglion cell, and f1 is the input.