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C:\Documents And Settings\Loretta Conners\My Documents\Rasmussen\Assignments\Unit Dose\Lconners Suppositories 012810

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Transcript

  • 1. SUPPOSITORIES
    TYPES AND DEFINITIONS
    COMPOSITION AND INGREDIENTS
    PREPARATION AND COMPOUNDING TECHNIQUES
  • 2. TYPES AND DEFINITIONS
    Solid dosage form used to administer medication by way of the rectum, vagina, or urethral tract
    Melt or undergo dissolution at body temperature, delivering needed drug either locally or systemically
  • 3. Rectal Suppositories
    Tapered at either one end or both
    Adult suppositories weigh approximately 2 grams and are from 1 to 1-1/2 inch long
    Infant suppositories are half the size of adult suppositories
  • 4. Vaginal Suppositories
    Available in a variety of shapes
    Usually weigh 3 to 5 grams each
    Made from water soluble bases such as polyethylene glycols or glycerinated gelatin
    Another form is a compressed tablet, also known as an insert
  • 5. Urethral Suppositories
    Pencil shaped with a 5 mm diameter
    Urethral suppository for a female is 50 mm in length and weighs approximately 2 grams
    Urethral suppository for a male is 125 mm in length and weighs about 4 grams
    Urethral suppositories are rarely prescribed
  • 6. COMPOSITION AND INGREDIENTS
    Bases used in compounding suppositories should be stable, nonirritating, and both chemically and physiologically inactive, and dissolve in the body cavity where inserted
    Choose base, considering patient sensitivities to ingredients, drug-base compatibility, solubility, stability, rate of release of drug, amount of drug to be incorporated, local or systemic effect
  • 7. PREPARATION AND COMPOUNDING TECHNIQUES
    Hand molding suppositories requires skills achieved with experience
    Use cocoa butter as base, cocoa butter is grated, weighed, and mixed with active ingredient using a mortar and pestle
    Mixture becomes a solid form, shape with hands into long cylinder, cut into desire length, and round the tip.
  • 8. PREPARATION AND COMPOUNDING TECHNIQUES
    Fusion method the base is melted using a water bath on a hotplate and poured into pre-calibrated molds.
    Active ingredient and excipients are stirred into the completely liquefied base
    Suppositories are cooled and hardened at room temperature, the excess is trimmed using a clean single-edge razor or heated spatula
  • 9. CONCLUSION
    When preparing suppositories, it is always advisable to prepare 10 percent excess to allow for loss during preparation and for overfilling