8–8.30. Outsmarting Smart Technology to Reclaim our Health and Focus
Dr. Margaret Morris, clinical psychologist, author of Left to Our Own Devices and former senior researcher at Intel
8.45–10.15am. Navigating the Brain Research Landscape
Dr. Peter Whitehouse, Professor of Neurology at Case Western Reserve University
Dr. Nir Grossman, Lecturer in the Division of Brain Sciences at Imperial College London
Dr. Reza Zomorrodi, Project Scientist at University of Toronto’s Centre for Addiction and Mental Health (CAMH)
Chaired by: Rebecca Canter, Associate at the Dementia Discovery Fund (DDF)
Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/
How to address privacy, ethical and regulatory issues: Examples in cognitive ...SharpBrains
How to address privacy, ethical and regulatory issues: Examples in cognitive enhancement, depression and ADHD
Dr. Karen Rommelfanger, Director of the Neuroethics Program at Emory University
Dr. Anna Wexler, Assistant Professor at the Perelman School of Medicine at UPenn
Jacqueline Studer, Senior VP and General Counsel of Akili Interactive Labs
Chaired by: Keith Epstein, Healthcare Practice Leader at Blue Heron
Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/
How will the Clinicians, Patients and Consumers of the Future ensure appropri...SharpBrains
*Dr. Eddie Martucci, Co-Founder and CEO of Akili Interactive Labs
*Dr. Anna Wexler, science writer, filmmaker and postdoc fellow at the Department of Medical Ethics and Health Policy at UPenn’s Perelman School of Medicine
*Dr. Olivier Oullier, President of EMOTIV
*Dr. Peter Reiner, Co-Founder of the National Core for Neuroethics at the University of British Columbia
*Chaired by: Dr. Alison Fenney, Executive Director of the Neurotechnology Industry Organization (NIO)
*Álvaro Fernández, CEO and Editor-in-Chief of SharpBrains
*Sarah Lenz Lock, Senior Vice President for Policy at AARP and Executive Director of the Global Council on Brain Health (GCBH)
*Dr. April Benasich, Director of the Baby Lab at the Rutgers Center for Molecular and Behavioral Neuroscience
*Chaired by: Dr. Cori Lathan, Co-Chair of the World Economic Forum’s Council on the Future of Human Enhancement
Slidedeck supporting session held during the 2017 SharpBrains Virtual Summit: Brain Health & Enhancement in the Digital Age (December 5-7th). Learn more at: https://sharpbrains.com/summit-2017/
How to promote brain health at scale: Examples in the workplace, K12 educatio...SharpBrains
How to promote brain health at scale: Examples in the workplace, K12 education and consumer tech
Louis Gagnon, CEO of Total Brain
Dr. Gregory Rose, Director of the Center for Integrated Research in Cognitive and Neural Sciences at SIU Med
Ariel Garten, Founder and Chief Evangelism Officer of InteraXon
Chaired by: Alvaro Fernandez, CEO and Editor-in-Chief at SharpBrains
Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/
How to intervene early: Examples in depression, epilepsy and smoking cessationSharpBrains
How to intervene early: Examples in depression, epilepsy and smoking cessation
Dr. Walter Greenleaf, Research Scientist at Stanford University’s Virtual Human Interaction Lab
David B. Klein, CEO of Click Therapeutics
Ana Maiques, CEO of Neuroelectrics
Chaired by: Avery Bedows, Neurotechnology Specialist at Loup Ventures
Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/
Building Up the Apollo Brain Data Exchange PortalSharpBrains
We will discuss opportunities and challenges arising from this core initiative, spearheaded by One Mind for Research, to provide open access to vast amounts of data and help close the gap between basic research and health outcomes.
- Chair: Alvaro Fernandez, CEO of SharpBrains
- Pete Chiarelli, CEO of One Mind for Research, U.S. Army General (Ret)
Navigating the Brain/ Mind Innovation Landscape & Book presentation El Cerebr...SharpBrains
Navigating the Brain/ Mind Innovation Landscape & Book presentation El Cerebro Que Cura (The Brain That Heals)
By Alvaro Fernandez, CEO and Editor-in-Chief at SharpBrains
Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/
Rethinking and Retooling Brain Health and Mental HealthSharpBrains
8–8.45. Rethinking and Retooling Brain Health and Mental Health
Dr. Tom Insel, Co-founder and President of Mindstrong Health and former Director of the National Institute of Mental Health (NIMH)
9–10.30. How to detect problems early: Examples in Alzheimer’s Disease, Parkinson’s, anxiety and PTSD
Dr. Srijan Sen, Professor of Depression and Neurosciences at University of Michigan
Jan Samzelius, Co-Founder and Chief Scientist of NeuraMetrix
Dr. Tony Chang, Associate at Merck Ventures
Chaired by: Dr. Deanna Belsky, Associate at Dolby Family Ventures
Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/
We will discuss the key highlights and forecasts from SharpBrains’ latest market report “The Digital Brain Health Market 2012–2020: Web-based, mobile and biometrics-based technology to assess, monitor and enhance cognition and brain functioning.”
- Alvaro Fernandez, CEO of SharpBrains
How to address privacy, ethical and regulatory issues: Examples in cognitive ...SharpBrains
How to address privacy, ethical and regulatory issues: Examples in cognitive enhancement, depression and ADHD
Dr. Karen Rommelfanger, Director of the Neuroethics Program at Emory University
Dr. Anna Wexler, Assistant Professor at the Perelman School of Medicine at UPenn
Jacqueline Studer, Senior VP and General Counsel of Akili Interactive Labs
Chaired by: Keith Epstein, Healthcare Practice Leader at Blue Heron
Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/
How will the Clinicians, Patients and Consumers of the Future ensure appropri...SharpBrains
*Dr. Eddie Martucci, Co-Founder and CEO of Akili Interactive Labs
*Dr. Anna Wexler, science writer, filmmaker and postdoc fellow at the Department of Medical Ethics and Health Policy at UPenn’s Perelman School of Medicine
*Dr. Olivier Oullier, President of EMOTIV
*Dr. Peter Reiner, Co-Founder of the National Core for Neuroethics at the University of British Columbia
*Chaired by: Dr. Alison Fenney, Executive Director of the Neurotechnology Industry Organization (NIO)
*Álvaro Fernández, CEO and Editor-in-Chief of SharpBrains
*Sarah Lenz Lock, Senior Vice President for Policy at AARP and Executive Director of the Global Council on Brain Health (GCBH)
*Dr. April Benasich, Director of the Baby Lab at the Rutgers Center for Molecular and Behavioral Neuroscience
*Chaired by: Dr. Cori Lathan, Co-Chair of the World Economic Forum’s Council on the Future of Human Enhancement
Slidedeck supporting session held during the 2017 SharpBrains Virtual Summit: Brain Health & Enhancement in the Digital Age (December 5-7th). Learn more at: https://sharpbrains.com/summit-2017/
How to promote brain health at scale: Examples in the workplace, K12 educatio...SharpBrains
How to promote brain health at scale: Examples in the workplace, K12 education and consumer tech
Louis Gagnon, CEO of Total Brain
Dr. Gregory Rose, Director of the Center for Integrated Research in Cognitive and Neural Sciences at SIU Med
Ariel Garten, Founder and Chief Evangelism Officer of InteraXon
Chaired by: Alvaro Fernandez, CEO and Editor-in-Chief at SharpBrains
Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/
How to intervene early: Examples in depression, epilepsy and smoking cessationSharpBrains
How to intervene early: Examples in depression, epilepsy and smoking cessation
Dr. Walter Greenleaf, Research Scientist at Stanford University’s Virtual Human Interaction Lab
David B. Klein, CEO of Click Therapeutics
Ana Maiques, CEO of Neuroelectrics
Chaired by: Avery Bedows, Neurotechnology Specialist at Loup Ventures
Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/
Building Up the Apollo Brain Data Exchange PortalSharpBrains
We will discuss opportunities and challenges arising from this core initiative, spearheaded by One Mind for Research, to provide open access to vast amounts of data and help close the gap between basic research and health outcomes.
- Chair: Alvaro Fernandez, CEO of SharpBrains
- Pete Chiarelli, CEO of One Mind for Research, U.S. Army General (Ret)
Navigating the Brain/ Mind Innovation Landscape & Book presentation El Cerebr...SharpBrains
Navigating the Brain/ Mind Innovation Landscape & Book presentation El Cerebro Que Cura (The Brain That Heals)
By Alvaro Fernandez, CEO and Editor-in-Chief at SharpBrains
Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/
Rethinking and Retooling Brain Health and Mental HealthSharpBrains
8–8.45. Rethinking and Retooling Brain Health and Mental Health
Dr. Tom Insel, Co-founder and President of Mindstrong Health and former Director of the National Institute of Mental Health (NIMH)
9–10.30. How to detect problems early: Examples in Alzheimer’s Disease, Parkinson’s, anxiety and PTSD
Dr. Srijan Sen, Professor of Depression and Neurosciences at University of Michigan
Jan Samzelius, Co-Founder and Chief Scientist of NeuraMetrix
Dr. Tony Chang, Associate at Merck Ventures
Chaired by: Dr. Deanna Belsky, Associate at Dolby Family Ventures
Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/
We will discuss the key highlights and forecasts from SharpBrains’ latest market report “The Digital Brain Health Market 2012–2020: Web-based, mobile and biometrics-based technology to assess, monitor and enhance cognition and brain functioning.”
- Alvaro Fernandez, CEO of SharpBrains
A Call to Action: Improving brain & mental health via digital platforms,...SharpBrains
(Session held at the 2014 SharpBrains Virtual Summit; October 28-30th, 2014)
8:15–9:45am. A Call to Action: Improving brain & mental health via digital platforms, neuroplasticity research and the White House BRAIN initiative
- Dr. Thomas Insel, Director of the National Institute of Mental Health (NIMH)
- Dr. Adam Gazzaley, Director of UCSF Neuroscience Imaging Center and Co-founder of Akili Interactive Labs
- Dr. Daphne Bavelier, Head of the Brain & Learning Lab at the University of Geneva & U. of Rochester
- Jack Young, Head of Qualcomm Life Fund
- Chair: Alvaro Fernandez, CEO of SharpBrains
Learn more here:
http://sharpbrains.com/summit-2014/agenda/
At the frontier of Big Data and Brain HealthSharpBrains
During this session we will explore cutting-edge initiatives to accelerate research & development via Big Data, crowdsourcing, technologies for the extended mind, and a range of data-rich pervasive neurotechnologies such as virtual reality.
-Chair: Alison Fenney, Director of Industry Alliances at the Neurotechnology Industry Organization (NIO)
-Dr. Walter Greenleaf, Distinguished Visiting Scholar at Stanford University’s Virtual Human Interaction Lab
-Michael Meagher, President of Cogniciti
-José Barrios, Co-Founder & CEO of Cognilab
-Dr. Peter Reiner, Co-Founder, National Core for Neuroethics at the University of British Columbia
Presentation @ The 2015 SharpBrains Virtual Summit http://sharpbrains.com/summit-2015/agenda
What are most promising lifestyle and tech options to harness lifelong neurop...SharpBrains
*Dr. Álvaro Pascual-Leone, Director of the Berenson-Allen Center for Noninvasive Brain Stimulation at Beth Israel Deaconess Medical Center
*Dr. David Bartrés-Faz, Principal Investigator of the Barcelona Brain Health Initiative (BBHI)
*Dr. Simone Schurle, Assistant Professor for Responsive Biomedical Systems at the Swiss Federal Institute of Technology
*Chaired by: Dr. David Bach, Founder and President of the Platypus Institute
*Álvaro Fernández, CEO and Editor-in-Chief of SharpBrains
*Sarah Lenz Lock, Senior Vice President for Policy at AARP and Executive Director of the Global Council on Brain Health (GCBH)
*Dr. April Benasich, Director of the Baby Lab at the Rutgers Center for Molecular and Behavioral Neuroscience
*Chaired by: Dr. Cori Lathan, Co-Chair of the World Economic Forum’s Council on the Future of Human Enhancement
Slidedeck supporting session held during the 2017 SharpBrains Virtual Summit: Brain Health & Enhancement in the Digital Age (December 5-7th). Learn more at: https://sharpbrains.com/summit-2017/
During Expo Day selected Summit Sponsors will showcase their latest initiatives and solutions:
-- Preview the Future of Brain Health with Anu Acharya, Founder and CEO of Map My Genome
-- The Alzheimer’s Research and Prevention Foundation (ARPF): Discuss new science and prevention initiatives with President Dr. Dharma Singh Khalsa.
-- FitBrains (a Rosetta Stone company): Explore ongoing big data research with Conny Lin, Data Research Scientist & Policy Analyst.
Presentation @ The 2015 SharpBrains Virtual Summit http://sharpbrains.com/summit-2015/agenda
How can Big Data help upgrade brain care?SharpBrains
Current standards of brain and mental care often rely on trials of insufficient scale, which not only limits our ability to diagnose, prevent, treat and personalize care but often leads to incorrect conclusions and undesirable results. What tools and data are becoming available via large-scale web-based and mobile applications, and how can researchers, innovators and practitioners connect with these initiatives?
- Chair: Alvaro Fernandez, CEO of SharpBrains, YGL Class of 2012
- Daniel Sternberg, Data Scientist at Lumosity
- Joan Severson, President of Digital Artefacts
- Robert Bilder, Chief of Medical Psychology-Neuropsychology at UCLA Semel Institute for Neuroscience
What do 7.5 billion human brains need to thrive in the Digital Age, and what ...SharpBrains
*Álvaro Fernández, CEO and Editor-in-Chief of SharpBrains
*Sarah Lenz Lock, Senior Vice President for Policy at AARP and Executive Director of the Global Council on Brain Health (GCBH)
*Dr. April Benasich, Director of the Baby Lab at the Rutgers Center for Molecular and Behavioral Neuroscience
*Chaired by: Dr. Cori Lathan, Co-Chair of the World Economic Forum’s Council on the Future of Human Enhancement
Slidedeck supporting session held during the 2017 SharpBrains Virtual Summit: Brain Health & Enhancement in the Digital Age (December 5-7th). Learn more at: https://sharpbrains.com/summit-2017/
Brain Health in the Pervasive Neurotechnology EraSharpBrains
Description: How to harness neuroplasticity and digital tools to enhance work and life. Led by decision-makers at the frontier of innovation, we will discuss how to guide interventions and measure progress using real-life outcomes such as safe driving and workplace/ sports performance.
- Chair: J. Peter Kissinger, President and CEO of the AAA Foundation for Traffic Safety
- Dr. Peter Delahunt, Research Scientist at Posit Science
- Dr. Ruth Wolever, Chief Science Officer at eMindful
- Danny Dankner, CEO of Applied Cognitive Engineering (ACE)
- Brig. General Pete Palmer (Retired), Director of the EDGE Innovation Network
Presentation @ The 2015 SharpBrains Virtual Summit http://sharpbrains.com/summit-2015/agenda
Update by Marcel Legrand, Chief Revenue Officer of Total BrainSharpBrains
During Expo Day selected Summit Sponsors and Partners showcased their most promising brain health & wellness initiatives and solutions.
Marcel Legrand, Chief Revenue Officer of Total Brain, will provide an overview of their new platform to better assess, understand and improve brain capacities.
Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/
Top Brainnovations to monitor and improve Brain HealthSharpBrains
Given the success of the first Brainnovations Pitch Contest, the 2019 Summit hosted a second Brainnovations edition for selected startups to pitch their innovative solutions to Summit participants and to our distinguished Judges — our very own “Sharp Tank.”
1–2.30pm. Top Brainnovations to monitor and improve Brain Health
Finalist: Kate Sharadin, Founder & CEO of eQuility
Finalist: Nickolai Vysokov, Co-Founder & CEO of BrainPatch
WINNER: Richard Hanbury, Founder & CEO of Sana Health
Judged by: Alexandra Morehouse, Chief Marketing Officer at Banner Health; Dr. Robert Bilder, Chief of Medical Psychology-Neuropsychology at UCLA; Elan Tye, Investor at JAZZ Venture Partners; Dr. Evian Gordon, Founder, Chairman and CMO of Total Brain; Dr. Hagit Alon, VP Scientific Affairs at Joy Ventures; John Cammack, Angel Investor; Kathleen Herath, Vice President Health & Productivity at Nationwide Insurance
Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/
During Expo Day selected Summit Sponsors showcased their latest initiatives and solutions:
-- Baycrest: Meet the new $100m+ Canadian Centre for Aging and Brain Health Innovation, with Dr. Randy McIntosh, Vice-president of Research and Director of Baycrest’s Rotman Research Institute.
-- Lumosity: Discuss emerging standards for cognitive research with Dr. Glenn Morrison, Director of Clinical Trials.
-- BrainBaseline: Explore the latest in mobile cognitive assessments with Joan Severson, President of Digital Artefacts.
-- Help improve and expand The SharpBrains Guide to Brain Fitness with co-author Alvaro Fernandez.
Presentations @ The 2015 SharpBrains Virtual Summit http://sharpbrains.com/summit-2015/agenda
Pervasive Neurotechnology: The Digital Revolution Meets the Human BrainSharpBrains
Slidedeck from June 30th, 2015 webinar, with Alvaro Fernandez and Nikhil Sriraman. to discuss the key take-aways from the new market report Pervasive Neurotechnology: A Groundbreaking Analysis of 10,000+ Patent Filings Transforming Medicine, Health, Entertainment and Business. To learn more: http://sharpbrains.com/pervasive-neurotechnology/
Agenda:
1–1.20pm ET: Five Key Trends Driving Neurotechnology to Become Pervasive
1.20–1.40pm ET: How Nielsen, Advanced Neuromodulation Systems, Medtronic, Microsoft and Brainlab emerged as leading IP Holders
1.40-2pm ET: Q&A
The three Finalists were:
*WEKIT — Wearable Experience for Knowledge Intensive Training — pitch by Paul Lefrere, Innovation Lead
*Sapien Labs (WINNER) — pitch by Tara Thiagarajan, Founder & Chief Scientist
*MyndYou — pitch by Shira Yama Nir, Project Manager
*Judged by: Bill Tucker, Senior Advisor to the K12 Education Program at the Bill & Melinda Gates Foundation; Eduardo Briceño, CEO and Co-founder of Mindset Works; John Cammack, Angel Investor; Neil Allison, Director of Business Model Innovation at Pearson North America
*Álvaro Fernández, CEO and Editor-in-Chief of SharpBrains
*Sarah Lenz Lock, Senior Vice President for Policy at AARP and Executive Director of the Global Council on Brain Health (GCBH)
*Dr. April Benasich, Director of the Baby Lab at the Rutgers Center for Molecular and Behavioral Neuroscience
*Chaired by: Dr. Cori Lathan, Co-Chair of the World Economic Forum’s Council on the Future of Human Enhancement
Slidedeck supporting session held during the 2017 SharpBrains Virtual Summit: Brain Health & Enhancement in the Digital Age (December 5-7th). Learn more at: https://sharpbrains.com/summit-2017/
The Clinical Practice Guidelines produced by the departments of Defense and Veterans Affairs provide a framework for ensuring evidence-based care for patients with mTBI. This webinar will demonstrate two mobile applications produced by the National Center for Telehealth & Technology that offer providers evidence-informed tools for the treatment and engagement in clinical care of patients with mTBI.
Best practices to assess and enhance brain function via mobile devices and ...SharpBrains
(Session held at the 2014 SharpBrains Virtual Summit; October 28-30th, 2014)
8:15–9:45am. Best practices to assess and enhance brain function via mobile devices and wearables
- Corinna E. Lathan, Founder and CEO of AnthroTronix
- Eddie Martucci, VP Research & Development at Akili Interactive Labs
- Alex Doman, Co-Founder of Sleep Genius
- Joan Severson, President of Digital Artefacts
- Chair: Keith Epstein, Senior Strategic Advisor at AARP
Learn more here:
http://sharpbrains.com/summit-2014/agenda/
Expo Day: Neuroenginnering, BPI, Arrowsmith Program & ARPFSharpBrains
Selected Summit Sponsors and Partners showcase their most promising brain health & enhancement initiatives and solutions.
Noon-1pm. From tomorrow’s neuroengineering to today’s brain health
*Dr. Randal Koene, Lead Scientist at Kernel, discusses future directions of neuroenginnering and human computer interfaces.
*Dr. Leanne Young, Executive Director of the Brain Performance Institute at UT-Dallas Center for BrainHealth presents the new 62,000-square-foot Brain Performance Institute.
1-1.30pm. Debbie Gilmore, Executive Director of The Arrowsmith Program, will present plans to better equip 100+ schools helping students with special needs.
1.30-2pm. Dr. Chris Walling, Chairman of the Educational Advisory Committee at The Alzheimer’s Research and Prevention Foundation (ARPF), will present the new Brain Longevity Therapy Training.
*Álvaro Fernández, CEO and Editor-in-Chief of SharpBrains
*Sarah Lenz Lock, Senior Vice President for Policy at AARP and Executive Director of the Global Council on Brain Health (GCBH)
*Dr. April Benasich, Director of the Baby Lab at the Rutgers Center for Molecular and Behavioral Neuroscience
*Chaired by: Dr. Cori Lathan, Co-Chair of the World Economic Forum’s Council on the Future of Human Enhancement
Slidedeck supporting session held during the 2017 SharpBrains Virtual Summit: Brain Health & Enhancement in the Digital Age (December 5-7th). Learn more at: https://sharpbrains.com/summit-2017/
How can front-line professionals incorporate the emerging brain health ...SharpBrains
(Session held at the 2014 SharpBrains Virtual Summit; October 28-30th, 2014)
12:30-2pm. How can front-line professionals incorporate the emerging brain health toolkit to their practices?
- Elizabeth Frates, Director of Medical Student Education at the Institute of Lifestyle Medicine
- Dr. Catherine Madison, Director of the Ray Dolby Brain Health Center at California Pacific Medical Center
- Barbara Van Amburg, Chief Nursing Officer at Kaiser Permanente Redwood City
- Dr. Wendy Law, Clinical Neuropsychologist at Walter Reed National Military Medical Center
- Chair: Dr. Michael O’Donnell, Editor-In-Chief of the American Journal of Health Promotion
Learn more here:
http://sharpbrains.com/summit-2014/agenda/
Scaling up meditation and mindfulness via wellness programs and biofe...SharpBrains
(Session held at the 2014 SharpBrains Virtual Summit; October 28-30th, 2014)
12:30-2pm. Scaling up meditation and mindfulness via wellness programs and biofeedback sensors
- Dr. Douglass Ziedonis, Professor and Chair of the Department of Psychiatry at UMass Medical School
- Dr. Dharma Singh Khalsa, President of the Alzheimer’s Research and Prevention Foundation
- Ariel Garten, CEO of InteraXon
- Dr. Evian Gordon, Executive Chairman of Brain Resource
- Chair: Rajiv Pant, Chief Technology Officer of The New York Times
Learn more here:
http://sharpbrains.com/summit-2014/agenda/
Update by Mel Barsky, Director at Centre for Aging + Brain Health Innovation ...SharpBrains
During Expo Day selected Summit Sponsors and Partners showcased their most promising brain health & wellness initiatives and solutions.
Mel Barsky, Director at Centre for Aging + Brain Health Innovation (CABHI), will introduce a new call for innovation where CABHI will be funding novel ideas from point-of-care workers that can help to improve brain health in older adults.
Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/
Health IT Summit Beverly Hills 2014 – Case Study “The Progression of Predictive Analytics: The Rothman Index” with Mark Headland, VP & CIO, Children’s Hospital of Orange County
This webinar is part of a 2-hour monthly series hosted by the Neurotechnology Innovation Network: https://ktn-uk.org/health/neurotechnology/
Each webinar features expert speakers and focusses on a new development in a different technology area.
The third topic in this series is Dementia treatment using a biodesign approach. Dementia can have enormous effects, not only to those suffering but also family members and others
caring for them, but there are currently no effective therapies available. Neurotechnology offers a new way of treating dementia.
There is growing evidence that technologies such as deep brain stimulation and transcranial magnetic stimulation could help treat some of the effects of dementia and brain-computer interfaces are now able to detect the first signs of dementia years before symptoms appear.
In collaboration with UK Dementia Research Institute this webinar explores novel neurotechnologies to treat dementia, discuss barriers to adoption and new opportunities in the field.
Magnets - Not Drugs: TMS IMMH San Antonio 2014Louis Cady, MD
In this talk, Dr. Cady covers a remarkable new treatment for depression: transcranial magnetic stimulation. The historical roots of this treatment are traced, followed by a review of the literature in terms of the proven efficacy of this treatment. A comparison with ECT shows that TMS has a very favorable profile, with remarkably fewer side effects and incredibly better tolerated side effects compared to ECT. Given that this was a "CME" talk, off-label uses of TMS were reviewed, including stepping stones for future avenues to explore
A Call to Action: Improving brain & mental health via digital platforms,...SharpBrains
(Session held at the 2014 SharpBrains Virtual Summit; October 28-30th, 2014)
8:15–9:45am. A Call to Action: Improving brain & mental health via digital platforms, neuroplasticity research and the White House BRAIN initiative
- Dr. Thomas Insel, Director of the National Institute of Mental Health (NIMH)
- Dr. Adam Gazzaley, Director of UCSF Neuroscience Imaging Center and Co-founder of Akili Interactive Labs
- Dr. Daphne Bavelier, Head of the Brain & Learning Lab at the University of Geneva & U. of Rochester
- Jack Young, Head of Qualcomm Life Fund
- Chair: Alvaro Fernandez, CEO of SharpBrains
Learn more here:
http://sharpbrains.com/summit-2014/agenda/
At the frontier of Big Data and Brain HealthSharpBrains
During this session we will explore cutting-edge initiatives to accelerate research & development via Big Data, crowdsourcing, technologies for the extended mind, and a range of data-rich pervasive neurotechnologies such as virtual reality.
-Chair: Alison Fenney, Director of Industry Alliances at the Neurotechnology Industry Organization (NIO)
-Dr. Walter Greenleaf, Distinguished Visiting Scholar at Stanford University’s Virtual Human Interaction Lab
-Michael Meagher, President of Cogniciti
-José Barrios, Co-Founder & CEO of Cognilab
-Dr. Peter Reiner, Co-Founder, National Core for Neuroethics at the University of British Columbia
Presentation @ The 2015 SharpBrains Virtual Summit http://sharpbrains.com/summit-2015/agenda
What are most promising lifestyle and tech options to harness lifelong neurop...SharpBrains
*Dr. Álvaro Pascual-Leone, Director of the Berenson-Allen Center for Noninvasive Brain Stimulation at Beth Israel Deaconess Medical Center
*Dr. David Bartrés-Faz, Principal Investigator of the Barcelona Brain Health Initiative (BBHI)
*Dr. Simone Schurle, Assistant Professor for Responsive Biomedical Systems at the Swiss Federal Institute of Technology
*Chaired by: Dr. David Bach, Founder and President of the Platypus Institute
*Álvaro Fernández, CEO and Editor-in-Chief of SharpBrains
*Sarah Lenz Lock, Senior Vice President for Policy at AARP and Executive Director of the Global Council on Brain Health (GCBH)
*Dr. April Benasich, Director of the Baby Lab at the Rutgers Center for Molecular and Behavioral Neuroscience
*Chaired by: Dr. Cori Lathan, Co-Chair of the World Economic Forum’s Council on the Future of Human Enhancement
Slidedeck supporting session held during the 2017 SharpBrains Virtual Summit: Brain Health & Enhancement in the Digital Age (December 5-7th). Learn more at: https://sharpbrains.com/summit-2017/
During Expo Day selected Summit Sponsors will showcase their latest initiatives and solutions:
-- Preview the Future of Brain Health with Anu Acharya, Founder and CEO of Map My Genome
-- The Alzheimer’s Research and Prevention Foundation (ARPF): Discuss new science and prevention initiatives with President Dr. Dharma Singh Khalsa.
-- FitBrains (a Rosetta Stone company): Explore ongoing big data research with Conny Lin, Data Research Scientist & Policy Analyst.
Presentation @ The 2015 SharpBrains Virtual Summit http://sharpbrains.com/summit-2015/agenda
How can Big Data help upgrade brain care?SharpBrains
Current standards of brain and mental care often rely on trials of insufficient scale, which not only limits our ability to diagnose, prevent, treat and personalize care but often leads to incorrect conclusions and undesirable results. What tools and data are becoming available via large-scale web-based and mobile applications, and how can researchers, innovators and practitioners connect with these initiatives?
- Chair: Alvaro Fernandez, CEO of SharpBrains, YGL Class of 2012
- Daniel Sternberg, Data Scientist at Lumosity
- Joan Severson, President of Digital Artefacts
- Robert Bilder, Chief of Medical Psychology-Neuropsychology at UCLA Semel Institute for Neuroscience
What do 7.5 billion human brains need to thrive in the Digital Age, and what ...SharpBrains
*Álvaro Fernández, CEO and Editor-in-Chief of SharpBrains
*Sarah Lenz Lock, Senior Vice President for Policy at AARP and Executive Director of the Global Council on Brain Health (GCBH)
*Dr. April Benasich, Director of the Baby Lab at the Rutgers Center for Molecular and Behavioral Neuroscience
*Chaired by: Dr. Cori Lathan, Co-Chair of the World Economic Forum’s Council on the Future of Human Enhancement
Slidedeck supporting session held during the 2017 SharpBrains Virtual Summit: Brain Health & Enhancement in the Digital Age (December 5-7th). Learn more at: https://sharpbrains.com/summit-2017/
Brain Health in the Pervasive Neurotechnology EraSharpBrains
Description: How to harness neuroplasticity and digital tools to enhance work and life. Led by decision-makers at the frontier of innovation, we will discuss how to guide interventions and measure progress using real-life outcomes such as safe driving and workplace/ sports performance.
- Chair: J. Peter Kissinger, President and CEO of the AAA Foundation for Traffic Safety
- Dr. Peter Delahunt, Research Scientist at Posit Science
- Dr. Ruth Wolever, Chief Science Officer at eMindful
- Danny Dankner, CEO of Applied Cognitive Engineering (ACE)
- Brig. General Pete Palmer (Retired), Director of the EDGE Innovation Network
Presentation @ The 2015 SharpBrains Virtual Summit http://sharpbrains.com/summit-2015/agenda
Update by Marcel Legrand, Chief Revenue Officer of Total BrainSharpBrains
During Expo Day selected Summit Sponsors and Partners showcased their most promising brain health & wellness initiatives and solutions.
Marcel Legrand, Chief Revenue Officer of Total Brain, will provide an overview of their new platform to better assess, understand and improve brain capacities.
Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/
Top Brainnovations to monitor and improve Brain HealthSharpBrains
Given the success of the first Brainnovations Pitch Contest, the 2019 Summit hosted a second Brainnovations edition for selected startups to pitch their innovative solutions to Summit participants and to our distinguished Judges — our very own “Sharp Tank.”
1–2.30pm. Top Brainnovations to monitor and improve Brain Health
Finalist: Kate Sharadin, Founder & CEO of eQuility
Finalist: Nickolai Vysokov, Co-Founder & CEO of BrainPatch
WINNER: Richard Hanbury, Founder & CEO of Sana Health
Judged by: Alexandra Morehouse, Chief Marketing Officer at Banner Health; Dr. Robert Bilder, Chief of Medical Psychology-Neuropsychology at UCLA; Elan Tye, Investor at JAZZ Venture Partners; Dr. Evian Gordon, Founder, Chairman and CMO of Total Brain; Dr. Hagit Alon, VP Scientific Affairs at Joy Ventures; John Cammack, Angel Investor; Kathleen Herath, Vice President Health & Productivity at Nationwide Insurance
Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/
During Expo Day selected Summit Sponsors showcased their latest initiatives and solutions:
-- Baycrest: Meet the new $100m+ Canadian Centre for Aging and Brain Health Innovation, with Dr. Randy McIntosh, Vice-president of Research and Director of Baycrest’s Rotman Research Institute.
-- Lumosity: Discuss emerging standards for cognitive research with Dr. Glenn Morrison, Director of Clinical Trials.
-- BrainBaseline: Explore the latest in mobile cognitive assessments with Joan Severson, President of Digital Artefacts.
-- Help improve and expand The SharpBrains Guide to Brain Fitness with co-author Alvaro Fernandez.
Presentations @ The 2015 SharpBrains Virtual Summit http://sharpbrains.com/summit-2015/agenda
Pervasive Neurotechnology: The Digital Revolution Meets the Human BrainSharpBrains
Slidedeck from June 30th, 2015 webinar, with Alvaro Fernandez and Nikhil Sriraman. to discuss the key take-aways from the new market report Pervasive Neurotechnology: A Groundbreaking Analysis of 10,000+ Patent Filings Transforming Medicine, Health, Entertainment and Business. To learn more: http://sharpbrains.com/pervasive-neurotechnology/
Agenda:
1–1.20pm ET: Five Key Trends Driving Neurotechnology to Become Pervasive
1.20–1.40pm ET: How Nielsen, Advanced Neuromodulation Systems, Medtronic, Microsoft and Brainlab emerged as leading IP Holders
1.40-2pm ET: Q&A
The three Finalists were:
*WEKIT — Wearable Experience for Knowledge Intensive Training — pitch by Paul Lefrere, Innovation Lead
*Sapien Labs (WINNER) — pitch by Tara Thiagarajan, Founder & Chief Scientist
*MyndYou — pitch by Shira Yama Nir, Project Manager
*Judged by: Bill Tucker, Senior Advisor to the K12 Education Program at the Bill & Melinda Gates Foundation; Eduardo Briceño, CEO and Co-founder of Mindset Works; John Cammack, Angel Investor; Neil Allison, Director of Business Model Innovation at Pearson North America
*Álvaro Fernández, CEO and Editor-in-Chief of SharpBrains
*Sarah Lenz Lock, Senior Vice President for Policy at AARP and Executive Director of the Global Council on Brain Health (GCBH)
*Dr. April Benasich, Director of the Baby Lab at the Rutgers Center for Molecular and Behavioral Neuroscience
*Chaired by: Dr. Cori Lathan, Co-Chair of the World Economic Forum’s Council on the Future of Human Enhancement
Slidedeck supporting session held during the 2017 SharpBrains Virtual Summit: Brain Health & Enhancement in the Digital Age (December 5-7th). Learn more at: https://sharpbrains.com/summit-2017/
The Clinical Practice Guidelines produced by the departments of Defense and Veterans Affairs provide a framework for ensuring evidence-based care for patients with mTBI. This webinar will demonstrate two mobile applications produced by the National Center for Telehealth & Technology that offer providers evidence-informed tools for the treatment and engagement in clinical care of patients with mTBI.
Best practices to assess and enhance brain function via mobile devices and ...SharpBrains
(Session held at the 2014 SharpBrains Virtual Summit; October 28-30th, 2014)
8:15–9:45am. Best practices to assess and enhance brain function via mobile devices and wearables
- Corinna E. Lathan, Founder and CEO of AnthroTronix
- Eddie Martucci, VP Research & Development at Akili Interactive Labs
- Alex Doman, Co-Founder of Sleep Genius
- Joan Severson, President of Digital Artefacts
- Chair: Keith Epstein, Senior Strategic Advisor at AARP
Learn more here:
http://sharpbrains.com/summit-2014/agenda/
Expo Day: Neuroenginnering, BPI, Arrowsmith Program & ARPFSharpBrains
Selected Summit Sponsors and Partners showcase their most promising brain health & enhancement initiatives and solutions.
Noon-1pm. From tomorrow’s neuroengineering to today’s brain health
*Dr. Randal Koene, Lead Scientist at Kernel, discusses future directions of neuroenginnering and human computer interfaces.
*Dr. Leanne Young, Executive Director of the Brain Performance Institute at UT-Dallas Center for BrainHealth presents the new 62,000-square-foot Brain Performance Institute.
1-1.30pm. Debbie Gilmore, Executive Director of The Arrowsmith Program, will present plans to better equip 100+ schools helping students with special needs.
1.30-2pm. Dr. Chris Walling, Chairman of the Educational Advisory Committee at The Alzheimer’s Research and Prevention Foundation (ARPF), will present the new Brain Longevity Therapy Training.
*Álvaro Fernández, CEO and Editor-in-Chief of SharpBrains
*Sarah Lenz Lock, Senior Vice President for Policy at AARP and Executive Director of the Global Council on Brain Health (GCBH)
*Dr. April Benasich, Director of the Baby Lab at the Rutgers Center for Molecular and Behavioral Neuroscience
*Chaired by: Dr. Cori Lathan, Co-Chair of the World Economic Forum’s Council on the Future of Human Enhancement
Slidedeck supporting session held during the 2017 SharpBrains Virtual Summit: Brain Health & Enhancement in the Digital Age (December 5-7th). Learn more at: https://sharpbrains.com/summit-2017/
How can front-line professionals incorporate the emerging brain health ...SharpBrains
(Session held at the 2014 SharpBrains Virtual Summit; October 28-30th, 2014)
12:30-2pm. How can front-line professionals incorporate the emerging brain health toolkit to their practices?
- Elizabeth Frates, Director of Medical Student Education at the Institute of Lifestyle Medicine
- Dr. Catherine Madison, Director of the Ray Dolby Brain Health Center at California Pacific Medical Center
- Barbara Van Amburg, Chief Nursing Officer at Kaiser Permanente Redwood City
- Dr. Wendy Law, Clinical Neuropsychologist at Walter Reed National Military Medical Center
- Chair: Dr. Michael O’Donnell, Editor-In-Chief of the American Journal of Health Promotion
Learn more here:
http://sharpbrains.com/summit-2014/agenda/
Scaling up meditation and mindfulness via wellness programs and biofe...SharpBrains
(Session held at the 2014 SharpBrains Virtual Summit; October 28-30th, 2014)
12:30-2pm. Scaling up meditation and mindfulness via wellness programs and biofeedback sensors
- Dr. Douglass Ziedonis, Professor and Chair of the Department of Psychiatry at UMass Medical School
- Dr. Dharma Singh Khalsa, President of the Alzheimer’s Research and Prevention Foundation
- Ariel Garten, CEO of InteraXon
- Dr. Evian Gordon, Executive Chairman of Brain Resource
- Chair: Rajiv Pant, Chief Technology Officer of The New York Times
Learn more here:
http://sharpbrains.com/summit-2014/agenda/
Update by Mel Barsky, Director at Centre for Aging + Brain Health Innovation ...SharpBrains
During Expo Day selected Summit Sponsors and Partners showcased their most promising brain health & wellness initiatives and solutions.
Mel Barsky, Director at Centre for Aging + Brain Health Innovation (CABHI), will introduce a new call for innovation where CABHI will be funding novel ideas from point-of-care workers that can help to improve brain health in older adults.
Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/
Health IT Summit Beverly Hills 2014 – Case Study “The Progression of Predictive Analytics: The Rothman Index” with Mark Headland, VP & CIO, Children’s Hospital of Orange County
This webinar is part of a 2-hour monthly series hosted by the Neurotechnology Innovation Network: https://ktn-uk.org/health/neurotechnology/
Each webinar features expert speakers and focusses on a new development in a different technology area.
The third topic in this series is Dementia treatment using a biodesign approach. Dementia can have enormous effects, not only to those suffering but also family members and others
caring for them, but there are currently no effective therapies available. Neurotechnology offers a new way of treating dementia.
There is growing evidence that technologies such as deep brain stimulation and transcranial magnetic stimulation could help treat some of the effects of dementia and brain-computer interfaces are now able to detect the first signs of dementia years before symptoms appear.
In collaboration with UK Dementia Research Institute this webinar explores novel neurotechnologies to treat dementia, discuss barriers to adoption and new opportunities in the field.
Magnets - Not Drugs: TMS IMMH San Antonio 2014Louis Cady, MD
In this talk, Dr. Cady covers a remarkable new treatment for depression: transcranial magnetic stimulation. The historical roots of this treatment are traced, followed by a review of the literature in terms of the proven efficacy of this treatment. A comparison with ECT shows that TMS has a very favorable profile, with remarkably fewer side effects and incredibly better tolerated side effects compared to ECT. Given that this was a "CME" talk, off-label uses of TMS were reviewed, including stepping stones for future avenues to explore
Functional Ultrasound (fUS) Imaging in the Brain of Awake Behaving MiceInsideScientific
To watch the webinar, visit:
https://insidescientific.com/webinar/functional-ultrasound-imaging-brain-awake-behaving-mice-neurotar-iconeus
Functional ultrasound (fUS) imaging is a new kid on the block in neuroimaging. It combines high spaciotemporal resolution with deep tissue penetration, which enables non-invasive whole-brain imaging in mice.
This exciting new technology complements and extends classical imaging modalities: it enables more straightforward, unobstructed and non-invasive functional measurements in mouse models of CNS diseases. Sensitive to changes in cerebral blood volume, fUS imaging is used to characterize brain networks with functional connectivity analysis and to measure the responses to sensory stimuli and pharmacological challenges.
fUS imaging performed in the brain of awake mice removes the biases and artifacts associated with the use of general anesthesia, which is no longer a “necessary evil” of translational imaging. Besides that: fUS imaging in awake mice allows integrating functional imaging with behavioral readouts starting from open field locomotion tracking to maze navigation and sociability studies.
In this webinar, you will learn:
– Functional ultrasound (fUS) imaging methodology
– How translational fUS neuroimaging helps to advance basic neuroscience research and preclinical drug discovery
– The main advantages and limitations of using functional ultrasound compared to other techniques such as BOLD fMRI
– The benefits of imaging in awake, head-restrained but otherwise freely moving mice
– Imaging functional activation, connectivity and pharmacologically-induced changes in awake and behaving mice
– How to combine fUS imaging with behavioral observation
Making Optical and Electrophysiological Measurements in the Brain of Head-Fix...InsideScientific
A growing number of researchers are moving from reduced preparations such as dissociated cultured neurons or brain slices, to experimentation in live animals - in vivo - using advanced methods such as two-photon microscopy or combined optogenetics and patch-clamp recordings. In order to immobilize the animal during these challenging applications general anesthesia is often administered; however, the use of anesthetics greatly distorts brain function.
Is there a better way?
In this exclusive webinar sponsored by Neurotar Ltd, leading experts in the technology will discuss methodology, best-practices and show attendees how to immobilize the rodent’s head without restraining its body using the Mobile HomeCage™. The result is a controlled research environment for studying brain function in awake, freely-moving subjects with no stress to the animal. Discussion around how this technique can be applied to the study of neuronal plasticity, neurodegeneration, addiction, brain trauma and other pathophysiological conditions in longitudinal experiments will be included. Furthermore, presenters will demonstrate how this methodology is best combined with microscopy and electrophysiology techniques – all in vivo.
Biofield Sciences has been developing a premedical, non invasive assessment protocol. This preventative approach has led us to imaging the human biofield, where the early warning signs of disease develop. Please visit our website www.biofieldscience.com and have a look at our new Biofield Viewer, www.biofieldviewer.com
Personalized Medicine and the Omics Revolution by Professor Mike SnyderThe Hive
Personalized medicine is expected to benefit from the combination of genomic information with the global monitoring of molecular components and physiological states. To ascertain whether this can be achieved, we determined the whole genome sequence of an individual at high accuracy and performed an integrated Personal Omics Profiling (iPOP) analysis, combining genomic, transcriptomic, proteomic, metabolomic, and autoantibodyomic information, over a 38-month period that included healthy and two virally infected states. Our iPOP analysis of blood components revealed extensive, dynamic and broad changes in diverse molecular components and biological pathways across healthy and disease conditions. Importantly, genomic information was also used to estimate medical risks, including Type 2 Diabetes, whose onset was observed during the course of our study. Our study demonstrates that longitudinal personal omics profiling can relate genomic information to global functional omics activity for physiological and medical interpretation of healthy and disease states.
Meet the speaker, Professor Michael Snyder (Stanford):
Michael Snyder is the Stanford Ascherman Professor, Chair of Genetics and the Director of the Center of Genomics and Personalized Medicine. He received his Ph.D. from the California Institute of Technology and postdoctoral training at Stanford University. He is a leader in the field of functional genomics and proteomics, and one of the major participants of the ENCODE project. His laboratory study was the first to perform a large-scale functional genomics project in any organism, and has launched many technologies in genomics and proteomics. These including the development of proteome chips, high resolution tiling arrays for the entire human genome, methods for global mapping of transcription factor binding sites (ChIP-chip now replaced by ChIP-seq), paired end sequencing for mapping of structural variation in eukaryotes, de novo genome sequencing of genomes using high throughput technologies and RNA-Seq. These technologies have been used for characterizing genomes, proteomes and regulatory networks. Seminal findings from the Snyder laboratory include; the discovery that much more of the human genome is transcribed and contains regulatory information than was previously appreciated, and a high diversity of transcription factor binding occurs both between and within species. He has also combined different state-of–the-art omics technologies to perform the first longitudinal detailed integrative personal omics profile (iPOP) of person and used this to assess disease risk and monitor disease states for personalized medicine. He is a co-founder of several biotechnology companies including; Protometrix (now part of Life Technologies), Affomix (now part of Illumina), Excelix, and Personalis, and he presently serves on the board of a number of companies.
Micro-Neuro-Sensor Recording of STN Neurons of the Human BrainMangaiK4
Abstract-What cause to the neurons of the human brain cells when they are damaged. They become inactive. So damage to subthalamiuc ucleus (STN) neurons of the human brain causing larger involuntary movements and thereby attacking the Parkinson’s disease (PD). Deep brain stimulation (DBS) of bilateral sub thalamic nuclei (STN) is an efficient method of rehabilitation technique in subjects with advanced idiopathic Parkinson’s (or Parkinson) disease. Accurate targeting of STN neurons and placement of microelectrodes/ (neurosensors) are paramount importance for optimal results after STN-DBS method.In this paper, microminiaturized electrode recordings (MER) of STN neurons were detected in a mean of 3.5 ±1.1 channels on right hemisphere and 3.6 ±1.04 on left hemisphere.Final channel selected were most commonly central seen in 42.3% followed by anterior in 33.7%. When a high current is delivered to STN or GPi neurons of basal ganglia (a component of human brain), causing their inhibition and improved indication of symptoms. It is now known that there is a significant change in the firing pattern and a reorganization of the entire basal ganglia circuit with DBS. The MER of STN neurons has identified a specific high frequency irregular larger amplitude firing patterns seen only in disease states and hence used to detect the neurons of ST nucleus during functional surgery. Micro electrode recording is so useful to confirm the right path but has to be taken in consideration with effects on macro stimulation.
Turn Away from Traditional Tethering and Towards a Better Method for Data Col...InsideScientific
Experts discuss the use of a novel movement responsive rodent caging system as a means to minimize animal stress and enable unique discovery in many research applications, namely neuroscience, animal behaviour, drug discovery and cardiometabolic disease.
Brain Health in 2030: Navigating Neuroplasticity & the Digital Health MarketSharpBrains
Keynote delivered by Alvaro Fernandez, CEO of SharpBrains, during corporate retreat.
Key message: "Our very human brains and minds are the most sophisticated technology at our disposal, so we should invest more time learning about how they work and harnessing neuroplasticity-based methods ways to improve them, augmented by digital tools --before jumping into invasive interventions."
What's New:
-- Lifelong neurogenesis and neuroplasticity
-- Building Cognitive Reserve
-- New toolkit & mindset: think Function, not Disease
We have an opportunity to establish a stronger and more resilient community, one that practices both physical and mental hygiene.
Update by Debbie Gilmore, Executive Director of The Arrowsmith ProgramSharpBrains
During Expo Day selected Summit Sponsors and Partners showcased their most promising brain health & wellness initiatives and solutions.
Debbie Gilmore, Executive Director of The Arrowsmith Program, will discuss plans to better equip 100+ schools helping students with special needs.
Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/
Update by Dr. Hagit Alon, VP Scientific Affairs of Joy VenturesSharpBrains
During Expo Day selected Summit Sponsors and Partners showcased their most promising brain health & wellness initiatives and solutions.
8.30am. Dr. Hagit Alon, VP Scientific Affairs of Joy Ventures, will present their “Neuro-Wellness” philosophy and approach to invest in scientific research and in entrepreneurs.
Update by Sydney Swaine-Simon, Co-Founder of NeurotechXSharpBrains
During Expo Day selected Summit Sponsors and Partners showcased their most promising brain health & wellness initiatives and solutions.
Sydney Swaine-Simon, Co-Founder of NeurotechX, will introduce their new learning resources and growing community of neurotech experts, entrepreneurs, and enthusiasts.
Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/
During Expo Day selected Summit Sponsors and Partners showcased their most promising brain health & wellness initiatives and solutions.
Xavier Louis, CEO of Peak, will discuss their plans to bring to market engaging, self-serve and evidence-based digital therapeutics.
Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/
Update by Dr. Lew Lim, Founder & CEO of VielightSharpBrains
During Expo Day selected Summit Sponsors and Partners showcased their most promising brain health & wellness initiatives and solutions.
Dr. Lew Lim, Founder & CEO of Vielight, will explore the latest on photobiomodulation and brain stimulation.
Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/
Cómo preparar la mente de nuestros alumnos para el siglo XXI...comenzando por...SharpBrains
Conferencia de Álvaro Fernández Ibáñez dentro del ciclo "Neurociencia y Educación" patrocinado por Ikasgiltza, la asociación de cooperativas laicas de enseñanza en el País Vasco.
Sobre el ponente: Experto a nivel internacional citado por medios como el New York Times o el Wall Street Journal, Álvaro Fernández Ibáñez casi 20 años en Estados Unidos. Hace diez lanzó junto con el científico Elkhonon Golberg la empresa SharpBrains para dar seguimiento a la ciencia del cerebro y a las nuevas tendencias tecnológicas e intentar ver cómo se pueden aplicar en la mejora de la educación, la salud y la mente.
Let’s master the digital toolkit to harness lifelong neuroplasticitySharpBrains
Four leading pioneers of applied neuroplasticity helped us navigate best practices to harness most promising non-invasive neurotechnologies, such as cognitive training, mindfulness apps, EEG and virtual/ augmented reality.
--Chair: Linda Raines, CEO of the Mental Health Association of Maryland
--Dr. Michael Merzenich, winner of the 2016 Kavli Prize in Neuroscience
--Dr. Judson Brewer, Founder & Research Lead of Claritas Mindsciences
--Tan Le, CEO of Emotiv
--Dr. Andrea Serino, Head of Neuroscience at MindMaze
Learn more at sharpbrains.com
Selected Summit Sponsors and Partners showcase their most promising brain health & enhancement initiatives and solutions.
8.30-10am. At the frontier with Neuroscape, VR/ AR and Photobiomodulation
*Adam Gazzaley, UCSF Professor of Neurology, presents Neuroscape
*Dr. Walter Greenleaf, Medical VR/ AR Expert at Stanford Virtual Human Interaction Lab, provides an overview of health applications of virtual & augmented reality (VR/AR)
*Dr. Lew Lim, Founder & CEO of Vielight, discusses photobiomodulation as a new way to enhance brain function
contact information.
10.30-11am. Dr. Bob Schafer, Director of Research at Lumos Labs, presents their expanding vision for brain training, including mindfulness.
*Álvaro Fernández, CEO and Editor-in-Chief of SharpBrains
*Sarah Lenz Lock, Senior Vice President for Policy at AARP and Executive Director of the Global Council on Brain Health (GCBH)
*Dr. April Benasich, Director of the Baby Lab at the Rutgers Center for Molecular and Behavioral Neuroscience
*Chaired by: Dr. Cori Lathan, Co-Chair of the World Economic Forum’s Council on the Future of Human Enhancement
Slidedeck supporting session held during the 2017 SharpBrains Virtual Summit: Brain Health & Enhancement in the Digital Age (December 5-7th). Learn more at: https://sharpbrains.com/summit-2017/
Top Brainnovation to boost Workplace Productivity and ResilienceSharpBrains
The three Finalists were:
*Beam Riders — pitch by Jafar Sabbah, Founder & CEO
*MyCognition — pitch by Martina Ratto, Cognitive Scientist
*The Touchpoint Solution (WINNER) — pitch by Dr. Amy Serin, Neuropsychologist & Co-Founder
*Judged by: Ariel Garten, Founder and Chief Evangelism Officer at InteraXon; Charlie Hartwell, Operating Partner at Bridge Builders Collaborative; Kathleen Herath, Associate Vice President Health & Productivity at Nationwide Insurance; Lisa Neuberger, Managing Director of Strategy + Innovation at Accenture Corporate Citizenship
*Álvaro Fernández, CEO and Editor-in-Chief of SharpBrains
*Sarah Lenz Lock, Senior Vice President for Policy at AARP and Executive Director of the Global Council on Brain Health (GCBH)
*Dr. April Benasich, Director of the Baby Lab at the Rutgers Center for Molecular and Behavioral Neuroscience
*Chaired by: Dr. Cori Lathan, Co-Chair of the World Economic Forum’s Council on the Future of Human Enhancement
Slidedeck supporting session held during the 2017 SharpBrains Virtual Summit: Brain Health & Enhancement in the Digital Age (December 5-7th). Learn more at: https://sharpbrains.com/summit-2017/
Top Brainnovation to improve Brain Health & PerformanceSharpBrains
The three Finalists were:
*Click Therapeutics — pitch by David Klein, Co-Founder & CEO
*AUGMENTx (WINNER) — pitch by Dr. Albert Kwon, Co-Founder & CEO
*Sincrolab — pitch by Ignacio de Ramon, Co-Founder & CEO
*Judged by: Alexandra Morehouse, Chief Marketing Officer at Banner Health; Colin Milner, Founder and CEO of the International Council on Active Aging (ICAA); Danny Dankner, CEO and Co-founder of Applied Cognitive Engineering; Zack Lynch, General Partner at JAZZ Venture Partners
*Álvaro Fernández, CEO and Editor-in-Chief of SharpBrains
*Sarah Lenz Lock, Senior Vice President for Policy at AARP and Executive Director of the Global Council on Brain Health (GCBH)
*Dr. April Benasich, Director of the Baby Lab at the Rutgers Center for Molecular and Behavioral Neuroscience
*Chaired by: Dr. Cori Lathan, Co-Chair of the World Economic Forum’s Council on the Future of Human Enhancement
Slidedeck supporting session held during the 2017 SharpBrains Virtual Summit: Brain Health & Enhancement in the Digital Age (December 5-7th). Learn more at: https://sharpbrains.com/summit-2017/
Digital Mental Health: the Hurt, the Hype, the Hope + Brainnovations Session 1SharpBrains
Digital Mental Health: the Hurt, the Hype, the Hope
* Dr. Tom Insel, President and Co-Founder of Mindstrong Health
Top Brainnovation to measure Brain Health & Performance. The three Finalists were:
*Savonix— pitch by Greg Wong, VP Product Management
*HealthTech Connex — pitch by Dr. Ryan D’Arcy, President & Chief Scientific Officer
*NeuraMetrix (WINNER) — pitch by Jan Samzelius, Co-Founder & CEO
*Judged by: Dr. Adam Haim, Chief of the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs at the National Institute of Mental Health (NIMH); Dr. David Barash, Chief Medical Officer and ED of Global Health at GE Foundation; Dr. Edward Kliphuis, Investment Director at Merck Ventures; Dr. Karen Postal, President of the American Academy of Clinical Neuropsychology (AACN)
*Álvaro Fernández, CEO and Editor-in-Chief of SharpBrains
*Sarah Lenz Lock, Senior Vice President for Policy at AARP and Executive Director of the Global Council on Brain Health (GCBH)
*Dr. April Benasich, Director of the Baby Lab at the Rutgers Center for Molecular and Behavioral Neuroscience
*Chaired by: Dr. Cori Lathan, Co-Chair of the World Economic Forum’s Council on the Future of Human Enhancement
Slidedeck supporting session held during the 2017 SharpBrains Virtual Summit: Brain Health & Enhancement in the Digital Age (December 5-7th). Learn more at: https://sharpbrains.com/summit-2017/
How can we harness digital technologies and artificial intelligence (AI) to s...SharpBrains
*Dr. Oliver Harrison. Chief Executive of the Health Moonshot at Telefónica Innovation
*Nancy Briefs, President and CEO of Digital Cognition Technologies
*Emma Yang, 9th grader, Creator of Timeless app and MIT Solver
*Belén Guerra-Carrillo, NSF Fellow and graduate student researcher at University of Califonia, Berkeley
*Chaired by: Kayt Sukel, science writer
*Álvaro Fernández, CEO and Editor-in-Chief of SharpBrains
*Sarah Lenz Lock, Senior Vice President for Policy at AARP and Executive Director of the Global Council on Brain Health (GCBH)
*Dr. April Benasich, Director of the Baby Lab at the Rutgers Center for Molecular and Behavioral Neuroscience
*Chaired by: Dr. Cori Lathan, Co-Chair of the World Economic Forum’s Council on the Future of Human Enhancement
Slidedeck supporting session held during the 2017 SharpBrains Virtual Summit: Brain Health & Enhancement in the Digital Age (December 5-7th). Learn more at: https://sharpbrains.com/summit-2017/
The Future of Brain Health and EnhancementSharpBrains
Keynote by Alvaro Fernandez at BrainFutures 2017. Washington, DC. September 6th, 2017.
Hundreds of science labs and companies around the globe are researching and developing new ways to help brain owners be smarter, sharper and healthier. What explains this flurry of activity, and where may it be headed? Which companies, technologies and solutions are gaining the most traction so far, and what are some of the best practices for appropriate use?
Five reasons the future of brain enhancement is digital, pervasive and (hopef...SharpBrains
Presentation by Alvaro Fernandez at the New York Neuropsychology Group (NYNG) 2017 Annual Spring Conference.
Hundreds of companies around the globe–now including Elon Musk’s Neuralink and even Facebook–are researching and developing new ways to help brain owners be smarter, sharper, and healthier. What explains this flurry of activity, and where may it be headed? What are the opportunities and challenges for the Neuropsychologists of the Future? We will structure the conversation around five emerging and thought-provoking statements:
1. There are 7.5 billion human brains out there, and everyone needs help 2. Lifelong neuroplasticity means all those brains can “sculpt” themselves 3. Mobile, sensing, wearable technologies, coupled with artificial intelligence (AI), provide a new platform to harness that neuroplasticity for good 4. Entrepreneurship and investments are fueling accelerated growth 5. Professionals are stepping up to help educate consumers and patients.
To learn more:
https://www.weforum.org/agenda/2017/05/five-reasons-the-future-of-brain-enhancement-is-digital-pervasive-and-hopefully-bright
Expo Day: Happy Neuron and Arrowsmith ProgramSharpBrains
During Expo Day selected Summit Partners and Sponsors showcased their latest initiatives and solutions.
--Franck Tarpin-Bernard, Managing Director of Scientific Brain Training (SBT), discussed new partnerships following their ISO 13485 certification for medical devices — cognitive remediation.
--Jessica Poulin, Strategic Operations Manager at the Arrowsmith Program, presented plans to better equip 100+ schools helping students with special needs.
Learn more at sharpbrains.com
Expo Day: MindMaze, SharpBrains, Watson Centre for Brain HealthSharpBrains
During Expo Day selected Summit Partners and Sponsors showcased their latest initiatives and solutions.
--Dr. Daniel Perez-Marcos, Senior Scientist at MindMaze, presented the MindMotion platform–a series of medical-grade virtual reality solutions for neurorehabilitation.
--Alvaro Fernandez. SharpBrains‘ CEO & Editor-in-Chief discussed The State of Brain Health Innovation.
--Mark Watson, Co-Director of the Watson Centre for Brain Health, explored latest research and programs for cognitive rehabilitation.
Learn more at sharpbrains.com
Essentials of Automations: The Art of Triggers and Actions in FMESafe Software
In this second installment of our Essentials of Automations webinar series, we’ll explore the landscape of triggers and actions, guiding you through the nuances of authoring and adapting workspaces for seamless automations. Gain an understanding of the full spectrum of triggers and actions available in FME, empowering you to enhance your workspaces for efficient automation.
We’ll kick things off by showcasing the most commonly used event-based triggers, introducing you to various automation workflows like manual triggers, schedules, directory watchers, and more. Plus, see how these elements play out in real scenarios.
Whether you’re tweaking your current setup or building from the ground up, this session will arm you with the tools and insights needed to transform your FME usage into a powerhouse of productivity. Join us to discover effective strategies that simplify complex processes, enhancing your productivity and transforming your data management practices with FME. Let’s turn complexity into clarity and make your workspaces work wonders!
In his public lecture, Christian Timmerer provides insights into the fascinating history of video streaming, starting from its humble beginnings before YouTube to the groundbreaking technologies that now dominate platforms like Netflix and ORF ON. Timmerer also presents provocative contributions of his own that have significantly influenced the industry. He concludes by looking at future challenges and invites the audience to join in a discussion.
Pushing the limits of ePRTC: 100ns holdover for 100 daysAdtran
At WSTS 2024, Alon Stern explored the topic of parametric holdover and explained how recent research findings can be implemented in real-world PNT networks to achieve 100 nanoseconds of accuracy for up to 100 days.
A tale of scale & speed: How the US Navy is enabling software delivery from l...sonjaschweigert1
Rapid and secure feature delivery is a goal across every application team and every branch of the DoD. The Navy’s DevSecOps platform, Party Barge, has achieved:
- Reduction in onboarding time from 5 weeks to 1 day
- Improved developer experience and productivity through actionable findings and reduction of false positives
- Maintenance of superior security standards and inherent policy enforcement with Authorization to Operate (ATO)
Development teams can ship efficiently and ensure applications are cyber ready for Navy Authorizing Officials (AOs). In this webinar, Sigma Defense and Anchore will give attendees a look behind the scenes and demo secure pipeline automation and security artifacts that speed up application ATO and time to production.
We will cover:
- How to remove silos in DevSecOps
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DevOps and Testing slides at DASA ConnectKari Kakkonen
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LF Energy Webinar: Electrical Grid Modelling and Simulation Through PowSyBl -...DanBrown980551
Do you want to learn how to model and simulate an electrical network from scratch in under an hour?
Then welcome to this PowSyBl workshop, hosted by Rte, the French Transmission System Operator (TSO)!
During the webinar, you will discover the PowSyBl ecosystem as well as handle and study an electrical network through an interactive Python notebook.
PowSyBl is an open source project hosted by LF Energy, which offers a comprehensive set of features for electrical grid modelling and simulation. Among other advanced features, PowSyBl provides:
- A fully editable and extendable library for grid component modelling;
- Visualization tools to display your network;
- Grid simulation tools, such as power flows, security analyses (with or without remedial actions) and sensitivity analyses;
The framework is mostly written in Java, with a Python binding so that Python developers can access PowSyBl functionalities as well.
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- For beginners: discover PowSyBl's functionalities through a quick general presentation and the notebook, without needing any expert coding skills;
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However, this ease of use means that the subject of security in Kubernetes is often left for later, or even neglected. This exposes companies to significant risks.
In this talk, I'll show you step-by-step how to secure your Kubernetes cluster for greater peace of mind and reliability.
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Speakers:
Bob Boule
Robert Boule is a technology enthusiast with PASSION for technology and making things work along with a knack for helping others understand how things work. He comes with around 20 years of solution engineering experience in application security, software continuous delivery, and SaaS platforms. He is known for his dynamic presentations in CI/CD and application security integrated in software delivery lifecycle.
Gopinath Rebala
Gopinath Rebala is the CTO of OpsMx, where he has overall responsibility for the machine learning and data processing architectures for Secure Software Delivery. Gopi also has a strong connection with our customers, leading design and architecture for strategic implementations. Gopi is a frequent speaker and well-known leader in continuous delivery and integrating security into software delivery.
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https://alandix.com/academic/papers/synergy2024-epistemic/
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• Communication Mining Overview
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Outsmarting Smart Technology to Reclaim our Health and Focus
1.
2.
3.
4.
5. Outsmarting Smart Technology to Reclaim
our Health and Focus
Dr. Margaret Morris, clinical psychologist,
author of Left to Our Own Devices and
former senior researcher at Intel
6. Left to Our Own Devices
Margaret Morris
SharpBrains
May 8, 2019
@margiemem
7.
8. The benefits of technologies depend on how much we make them our own.
9. Stories from Left to Our Own Devices
“I’m your Stress Phone!”
The Big Mouth Scale
Do you Know Where your Children Are?
Remembering the Context, Calm Alarms
Words with Socially Anxious Friends
10. Morris et al. Mobile therapy and mood sampling. JMIR 2010
“We looked at his build up . . . towards me and towards the teacher . . .
We talked about what happened for me, which was that I was embarrassed.”
“I’m your stress phone!”
11. “I got this email from my scale . . . `Congratulations you’ve lost 15 lbs!’”
The Big Mouth Scale
12. East London
Walking home from the bus
At the bus stationCentral London
“This replaced a daily reminder that our parents have made clear they require from us…”
Morris, Carmean, Minyaylov, Ceze. Augmenting Interpersonal Communication through Connected Lighting. CHI 2017
Do You Know Where Your Children Are?
16. There’s not one app for that.
Broaden the idea of health technology to include the tools that
are already part of patient’s lives.
No size fits all.
Encourage and design for adaptation.
Cognitive health is social.
Support interpersonal uses of personal health technologies.
19. Navigating the Brain Research Landscape
Chaired by: Rebecca
Canter, Associate at
the Dementia Discovery
Fund (DDF)
Dr. Nir Grossman, Lecturer in
the Division of Brain Sciences
at Imperial College London
Dr. Reza Zomorrodi,
Project Scientist
at University of Toronto’s
Centre for Addiction and
Mental Health (CAMH)
Dr. Peter Whitehouse,
Professor of Neurology
at Case Western Reserve
University
20. Wising up: designing a course*
for the future
Peter J Whitehouse MD-PhD
Case Western Reserve University, University of Toronto,
and University of Oxford
Intergenerational Schools International
* A real and virtual; intergenerative and transdisciplinary brain
health course
21.
22. The Course
• Learning objectives - rehumanized humans, flourishing civilizations,
and resilient ecosystems
• Learning subjectives –brain health with depth (purpose) and breadth
(community)
• The Future – Brain health in an unhealthy society –Alzheimers
explained the books
• Intergenerative – Intergenerational Schools,
• Transdisciplinarity – e.g. a deeper bioethics
• Trees and Forests –Sylvanus the video game
• Wising up about wisdom – the course
25. Brain Health in an Unhealthy Society:
a social prescription for wising up
together
Danny George PhD and Peter Whitehouse MD-PhD
Hopkins Press, forthcoming
neoliberalism (individual-focused, market
fundamentalism) causes dementia through social
determinants of health
37. Goal – to save the healing spirit of the forest
38.
39.
40. Wising up: designing a course* for the future
Content – brain health, positive aging,
intergenerational learning, sustainable communities,
digital technologies, art
Process – participatory design, experiential, service
Students – elders, undergrads, youngsters
Capstone – spirited citizenship in a museum
43. Noninvasive deep brain stimulation
via delivery of temporally interfering
electric fields
Nir Grossman, PhD
Nir Grossman, et al., Cell 169.6 (2017)
Nir Grossman, Science 361.6401 (2018)
Division of Brain Sciences, Centre for Bioinspired Technology,
Centre for Neurotechnology, Imperial College London (ICL)
UK Dementia Research Institute (DRI)
Media Lab and McGovern Institute for Brain Research,
Massachusetts Institute of Technology (MIT)
44. 1 billion people
depression
obesity
anxiety
chronic pain
sleep
disorders
addiction
Alzheimer’s
disease
stroke
TBI
vision losshearing loss
migraine
epilepsy
Parkinson’s
disease
ADHD
multiple sclerosis
schizophrenia
autism
ALS
tinnitus
Brain Stimulation
Invasive, Focal,
Deep
Non-invasive, Dispersed,
Superficial
Invasive, Focal,
Deep
Non-invasive, Dispersed,
Superficial
Non-invasive, Steerable, 3D Focal Brain Stimulation
Without tissue manipulation (chemical, genetic etc.)
45. Outline
Principle of Stimulation
Validation 1: Driving Neural Activity in Vivo, Assessment With
Single Cell Recording
Validation 2: Recruitment of Deep Brain Structures, Without
Overlying Layers
Validation 3: Safety
Validation 4: Functional Mapping of Brain Regions, With
Steerable Stimulation
Validation 5: Steerable activation of resting-state BOLD fMRI in
humans (unpublished)
47. Validation 1: Driving Neural Activity in-vivo
20 mV
200 𝜇A
100 ms
2 kHz
5sweeps
-50 mV
𝐼1 𝐼2
Patch-clamp
electrode
Single cell
activity
20 mV
200 𝜇A
100 ms
10 Hz
5sweeps
-50 mV 5 ms
20 mV
100 𝜇A
100 ms
-50 mV
100 𝜇A
5 ms
5sweeps
2.01 kHz
2 kHz
All traces were filtered (Butterworth high-pass 100Hz
and band-stop 1kHz-15kHz) to remove stimulation artefacts.
48. 100 𝜇A
2.01 kHz
100 ms
20 mV
100 𝜇A
2 kHz
5 ms
10 mV
-47 mV
2 kHz 200 𝜇A
100 ms
20 mV
-48 mV
-54 mV 100 ms
20 mV
2.01 kHz
2 kHz 400 𝜇A
400 𝜇A
10 ms
10 mV
-49 mV 100 ms
20 mV
2 kHz
2 kHz 400 𝜇A
400 𝜇A
Validation 1: Driving Neural Activity in-vivo
0.25 0.5
Fractionofcells
0.25 s ramp-up (Crtx) 0.5 s ramp-up (Hipp)
Crtx, Cortex; Hipp, Hippocampus; All traces were filtered (Crtx: Butterworth high-pass 100Hz and band-stop 1kHz-
15kHz; Hipp: Butterworth band-stop 1kHz-15kHz) to remove stimulation artefacts.
Fraction of cells that spiked during
high-frequency ramp-ups
(pooled are 1 kHz and 2 kHz trials)
49. Validation 1: Driving Neural Activity in-vivo
One-way ANOVA with Bonferroni post-hoc test. ∗∗ P < 0.00001 for comparison vs. mean spontaneous firing rate.
Cortex (Crtx):10 Hz stimulation (200 μA, n = 7 cells from 4 mice), TI stimulation with 1 kHz + 1.01 kHz (current sum
200 μA, n = 6 cells from 2 mice), TI stimulation with 2 kHz + 2.01 kHz (current sum 200 μA, n = 7 cells from 3 mice),
1 kHz stimulation (200 μA, n = 5 cells from 2 mice), 2 kHz stimulation (200 μA, n = 6 cells from 3 mice).
Hippocampus (Hipp):10 Hz (current sum 714 ± 367 μA mean ± SD, n = 6 cells from 3 mice), TI stimulation with 2
kHz + 2.01 kHz (current sum 733 ± 100 μA, n = 8 cells from 4 mice), stimulation with two sinusoids at 2 kHz (current
sum 880 ± 178 μA, n = 5 cells from 3 mice).
Mean (± st.d.) Firing
Rate (Crtx)
𝐼1 𝐼2
Patch-clamp
electrode
*** *** ***
n.s.
n.s. n.s.
spontaneous
firing
***
***
n.s.
spontaneous
firing
Mean (± st.d.) Firing/Bursting
Rate (Hipp)
57. Whisker Whisker
Forelimb
𝐼1 𝐼2
Validation 4: Functional Mapping of Brain Regions
Forelimb
N = 9 mice
Significance of movements was confirmed with unpaired t-test with Bonferroni correction; * p < 0.002, ** p < 0.00001
Significance between current ratios was confirmed with one-way ANOVA with Bonferroni post-hoc test; * p < 0.05
Mice motor cortex map: see for example K.A. Tennant, Cerebral Cortex, 2011
Mean (± s.e.m) Whisker Movement
Mean (± s.e.m) Forepaw Movement
Movement
Contralateral
(to 𝐼1)
Ipsilateral
(to 𝐼1)
59. Duke ViP3.0 modelSubject 07
Study design
× 4
(random order)
10 Hz No stimulation 2 kHz No stimulation
TI (1:1) No stimulation TI (3:1) No stimulation TI (1:3)
No stimulation Sham
No stimulation
Electrode configuration
Validation 5: Resting-state fMRI in human
𝐸 <
1
𝑒
𝐸 𝑚𝑎𝑥ROI frontal
ROI dorsal
Personalized FEM modelStructure MRI E Field & ROI
Analysis strategy
Location: Martinos Imaging Center, MIT; Subjects: 9 healthy volunteers (3 females; mean age 27.5 ±5); MRI: 3T
MAGNETOM Trio (Siemens Healthcare);
Unpublished data
60. TI (1:1) 2.01 kHz, 1 mA + 2 kHz, 1 mA
TI (3:1) 2.01 kHz, 1.5 mA + 2 kHz, 0.5 mA
Unpublished data
Validation 5: Resting-state fMRI in human
First-level analysis: small volume correction with cluster threshold at p<0.01.
Second-level analysis: individual T-maps were thresholded at p<0.01 (voxel-level) and peak clusters were extracted,
significance between frontal and dorsal ROIs was characterized via pairwise t-test, * p < 0.05, n = 9 subjects
TI (1:3) 2.01 kHz, 0.5 mA, 2 kHz, 1.5 mA
Peak T-score
(Condition-Baseline;
across subjects)
61. Summary
Temporal Interference (TI) – a new brain stimulation modality
• Based on superposition of multiple kHz electric fields
Validation experiments
• Driving action potential activity in-vivo (mouse)
• Recruitment of hippocampus without overlying cortex (mouse)
• Functional mapping of motor cortex with fixed electrodes (mouse)
• Safety (mouse)
• Steerable activation of resting-state BOLD fMRI (humans)
New capabilities to existing brain stimulation ecosystem
No tissue manipulation → Fast clinical adoption
62. David Bono (MIT)
Suhasa Kodandaramaiah (MIT, University of
Minnesota)
Andrii Rudenko (MIT, City University of York)
Nina Dedic (MIT)
Ho-Jun Suk (MIT)
Antonino Cassara (IT’IS foundation)
Esra Neufeld (IT’IS foundation)
Sheeba A. Anteraper (MIT)
Atsushi Takahashi (MIT)
Niels Kuster (IT’IS foundation)
Li-Huei Tsai (MIT, Broad Institute)
Alvaro Pascual-Leone (Harvard)
Ed S. Boyden (MIT)
Acknowledgments
63. Shining light on the Brain:
Photobiomodulation as a
new non-Invasive Brain
Stimulation
Reza Zomorrodi, Ph.D
Project Scientist
Temerty Centre for Therapeutic Brain Intervention
Centre for Addiction and Mental Health
64. The Brain is an Electro-Chemical organ
Idan Segev, What changes in the brain when we learn? Franco Israeli
Scientific Colloquium on Memory, Paris, October 23 Rd , 2006
65. Electrochemical impulse
Reza Zomorrodi et al ,Modeling thalamocortical cell: impact of Ca2+ channel
distribution and cell geometry on firing pattern, Front. Comput. Neurosci., 2008
Neurons communicate with each other via
electrical events called 'action potentials' and
chemical neurotransmitters.
66. What does influence neuron firing pattern?
Picture from Wikipedia (http://en.wikipedia.org/wiki/Neuron)
extracellularoscillations
Dendriticmorphology
Intercellular, Extracellular properties….whatever a neuron is made of
67. Does function follow form? $$$
What does influence neuron firing pattern?
Intercellular, Extracellular properties….whatever a neuron is made of
Alter any of these properties change in firing pattern
Brain Stimulation
68. Polanaia R, et al. Studying and Modifying Brain Functions with
Non-invasive Brain Stimulation. Nat. Neurosc. 2018.
Existing “Non-Invasive” Brain Stimulation Methods
Based on Electro-Chemical properties of the Brain
69. Polanaia R, et al. Studying and Modifying Brain Functions with
Non-invasive Brain Stimulation. Nat. Neurosc. 2018.
Existing “Non-Invasive” Brain Stimulation Methods
Based on Photo-Chemical properties of the Brain
Photo-
Biomodulation
70. Hamblin MR, Mechanisms and applications of the anti-inflammatory effects
of photobiomodulation, AIMS Biophysics, 2017, 4(3): 337
Photobiomodulation(PBM)
• Cytochrome c oxidase in respiratory
chain absorbs mainly red (and NIR)
light by heme and copper;
• Heat-gated TRP ion channels absorb
NIR (and blue light) via structured
water;
• Opsins absorb mainly blue/green
light via cis-retinal;
• Flavoproteins and cryptochromes
absorb mainly blue light via
pterin
The PBM biological response begins with chromophores(photoreceptors), photon accepting
molecules which convert light into signals that can stimulate certain biological processes
71. Photobiomodulation : Visual stimulation
(Light Therapy)
Circadian Rhythms – Our Body ClockPhotoreceptors
Zvi N Roth et al Stimulus vignetting and orientation
selectivity in human visual cortex, eLife 2018
orientation selectivity in human
visual cortex
72. Accidental discovery of photobiostimulation in 5 steps!
almost 50 years ago by Endre Mester in Hungary
Experiments with mice
1. Could laser be used to treat cancerous tumors?
2. Used low power ruby laser (694 nm)
3. Laser treatments did NOT kill tumor cells
4. Laser treatments DID enhance healing of incisions
and hair growth
5. First to observe photobiostimulation
Photobiomodulation:
Endre Mester, M.D. 1903-1984
Skin/injuries; Skin/pathology; Wound Healing/radiation
73. Karu T.I. (2003). Low-power laser therapy. In: Biomedical Photonics Handbook (T. VoDinh, ed.)
CRC Press, Boca Raton, FL, 48, pp. 1-2
Incoming red and NIR photons are
absorbed in cell mitochondria,
producing reactive oxygen species
(ROS) and releasing nitric oxide (NO),
which leads to gene transcription via
activation of transcription factors (NF-
kB and AP1).
Photobiomodulation : Transcranial
photobiomodulation
74. Photobiomodulation benefits
Hamblin, MR. Shining light on the head: Photobiomodulation for brain disorders. BBA
Clin. 2016 Oct 1;6:113-124. eCollection 2016.
1. Increases ATP synthesis
2. Stimulates cell growth
3. Increases cell metabolism
4. Improves cell regeneration
5. Invokes an anti-inflammatory
response
6. Promotes edema reduction
7. Reduces fibrous tissue
formation
8. Stimulates nerve function
9. Reduces the production of
substance P
10.Stimulates long term
production of NO
11. Decreases the formation of
bradikynin, histamine, and
acetylcholine
12. Stimulates production of
endorphins
81. PBM-EEG study: Power Spectrum analysis
Topographical distribution of EEG power
spectrum for active/sham and per/post PBM
Average (over all channels) of EEG power
spectrum for active/sham and per/post PBM
Active: Post-Pre
Sham: Post-Pre
Pre: Active-Sham
Post: Active-Sham
• Both Active and Sham significantly changed EEG power spectrum
• Active tPBM caused a depression in lower frequency (delta, theta)
and facilitation in higher frequency bands(alpha, beta, gamma)
power spectrum
83. Connectivity Analysis
A network based on weighted phase lag index (wPLI) was constructed and graph measures were employed to
evaluate network features. wPLI is a functional connectivity measure and assesses the phase ‘lagging’
consistency between each pair of EEG channels
To assess segregation: Cluster Coefficient CC 𝒗 =
𝟐∗(# 𝒍𝒊𝒏𝒌𝒔 𝒃𝒆𝒕𝒘𝒆𝒆𝒏 𝒏𝒆𝒊𝒈𝒉𝒃𝒐𝒓 𝒐𝒇 𝒗)
𝒅𝒆𝒈𝒓𝒆𝒆 𝒐𝒇 𝒗
To assess integration: Characteristic path length (CPL) =
𝒗 𝒋 𝑳𝒗𝒋
𝑵(𝑵−𝟏)
To assess the efficiency of information flow: Efficacy (v) =
𝟏
(𝑵−𝟏) 𝒗≠𝒋
𝟏
𝑳𝒗𝒋
Lvj is the shortest path length between v th node and j th node. N is total number of nodes.
CC = 1 CC = 1/2 CC = 0
PBM-EEG study: Connectivity analysis
84. PBM-EEG study: Connectivity analysis
Frequency band (Hz)
Sparcity level (1-99)%
Connectivityindex
• Only active tPBM changed connectivity index
• Most significant change occurred in Alpha frequency band network
85. Does “tPBM” really work ?!
First Double-Blind pilot study results showed that it:
• changed cortical oscillation and
• altered Neural network connectivity
Photobiomodulation is a new non-invasive brain stimulation,
which is easily
• Can target several location
• Can modulate brain activity
• and Safe & Easy to use
86. Thank You!
Reza Zomorrodi, Ph.D
Project Scientist
Temerty Centre for Therapeutic Brain Intervention
Centre for Addiction and Mental Health
Unit 4-1, Office 125A
1001 Queen Street West, Toronto, ON. M6J 1H4
Reza.Zomorrodi@camh.ca
(Tel) 416-535-8501 ext 30205
I would be happy to hear your questions/comments
tPMB-EEG study was supported by
Vielight Inc.,
I no competing or conflict of interest,
financial and non-financial.