This document provides information about isotretinoin (Accutane), including what it is, how it works to treat acne, recommended dosages, side effects, and precautions for its use. Isotretinoin is an oral medication used to treat severe cystic acne. It works by reducing oil and inflammation in the skin. Special prescribing requirements include monthly pregnancy tests for women and using contraception during treatment due to potential birth defects. Common side effects include dry skin, lips and eyes.

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Raw Isotretinoin (Accutane) for acne: Treating
Acne with Isotretinoin
What is Isotretinoin (Accutane)?........................................................................2
What is cystic acne? ........................................................................................... 2
Isotretinoin Brand Name......................................................................................4
How does Isotretinoin Work?..............................................................................4
Raw Isotretinoin for acne Treatment................................................................. 5
How to use Isotretinoin........................................................................................6
Isotretinoin dosage...............................................................................................7
Isotretinoin usage................................................................................................. 8
What to avoid while taking isotretinoin..............................................................9
Missed Accutane (isotretinoin) dose .............................................................. 10
Special prescribing requirements ................................................................... 10
What are the side effects of Accutane ........................................................12
Does Isotretinoin also cause depression? .................................................... 14
How to deal with the side effects of Accutane............................................... 15
Is Isotretinoin Safe to Use?............................................................................. 16
How to buy Accutane (isotretinoin) online......................................................17
How are you supposed to store Accutane (isotretinoin)?............................ 17
Isotretinoin Reviews...........................................................................................17
Isotretinoin online............................................................................................... 19

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Meta-description
Isotretinoin is an ultra-effective acne treatment. Here, you’ll see the isotretinoin
reviews,isotretinoin uses, isotretinoin side effects and other information about
the medicine, including the dosage and the precaution measures.
What is Isotretinoin (Accutane)?
Are you in search of raw isotretinoin (Isotretinoin 4759-48-2)? Well, in case
you are not familiar with it, Isotretinoin is a strong oral prescription drug. About
isotretinoin uses, the medicine is used for the treatment and prevention of
severe, disfiguring nodular acne or cystic acne.
When it comes to Isotretioin chemical properties, raw isotretinoin is basically
13-cis-retinoic acid. It comes as a yellow to orange sparkling powder and has a
molecular weight of 300.44. It’s associated with retinoic acid as well as retinol
(vitamin A).
What is cystic acne?

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Perhaps you are wondering
what is cystic
acne. A cystic acne is a
severe form of acne which
results from blocked skin
pores, causing an infection
and inflammation. Many
people, approximately 80
percent of those aged
between 11 and 30 years
suffer from acne, but only a
small fraction of them have
cystic acne, which is more
severe than the usual acne.
An acne cyst is usually
larger and more inflamed
than a regular pimple and
might not go away even
after you take some
treatment for acne. A cystic
pimple can be painful and
mostly leaves behind a
deep scar.
Maybe your acne continues to proliferate despite your countless efforts to get
rid of it. You don’t need to look for proliferation synonym. The term simply
means a rapid increase in the amount of something, in this case, acne. So,
proliferation synonym is multiplication, spread, or escalation.
Now, that aside.
In case you have tried all other medical methods such as oral antibiotics and
various topical medications to treat a cystic pimple or acne cyst, but in vain,
Isotretinoin will most likely be the ultimate solution. Besides, the drug can also
be used as a treatment for other skin conditions, depending on the doctor’s
recommendation.

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Isotretinoin Brand Name
Isotretinoin is a retinoid drug, a product of a synthetic vitamin A. it is also
known by its brand names:
Absorica,
Accutane,
Amnesteem,
Claravis,
Myorisan,
Sotret
Zenatane.
Also, the drug is available in various generic versions.
How does Isotretinoin Work?
Besides, Isotretinoin uses, perhaps you are wondering, “how does Accutane
work?” Why is it is so powerful that it can do what some antibiotics and topical
medications can’t?
Well, here’s an explanation of the answer to the question ‘how does Accutane
work?’
Similarly to other retinoid drugs, Isotretinoin functions by changing your DNA
transcription. The effect of the alteration is the reduction of the size as well as
the production of the sebaceous glands.
When you take Isotretinoin, it shrinks your skin’s sebaceous glands which are
responsible for the sebum production. Sebum is an oily substance and its
excessive production can lead to various skin issues such as acne.
The excessive sebum blocks the sebaceous glands, preventing the skin oil
from flowing out. This causes the accumulation of the oil beneath the skin. The

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bacteria which cause cystic acne (acne vulgaris) tend to thrive in such
condition as sebum is their food.
When Acne vulgaris feed on the sebum in your skin, they produce waste
products as well as fatty acids. The excreta and the acids irritate the
sebaceous glands and make them get inflamed. Skin spots also occur as a
result.
So, when Isotretinoin shrinks the sebaceous glands, the amount of their
sebum production reduces. As a result, the clogging of cores by the sebum is
minimized as well. Considering that pimples, or rather acne, mostly occurs as
a result of skin pore clogging by sebum, the effect of the medication controls
them.
It prevents the blockage of the sebaceous glands and so, there is minimal
likelihood for bacteria to thrive in the skin. The drug also reduces skin
inflammation. Besides, the drug also reduces the stickiness of the cells that
have been shed off into the sebaceous glands. This reduces their capability to
form blackheads and whiteheads.
Raw Isotretinoin for acne Treatment
Isotretinoin 4759-48-2 is undoubtedly the ultimate acne treatment, particularly
for severe cases where the use of antibiotics and topical acne medications has
been rendered futile. One awesome thing about Isotretinoin as a treatment for
acne is that you might have to use it for just a short span of time, perhaps 16 to
20 weeks to say goodbye to your pimples, no matter how severe they are.
Nevertheless, your dermatologist may recommend a second course of
treatment of a similar duration to for the full clearance of your acne. This is
unlike the majority of other acne drugs which you might need to use
continuously for an extended period or even forever to keep acne at bay.
Although it’s rare for you to get pimples again once you are done with
Isotretinoin course of treatment, your skin care specialist may advise you to
transition to a topical acne medication for the maintenance of your new,
acne-free skin.

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How long does take for one to start seeing Accutane results?
This might take you by surprise if have never heard about it because it is the
opposite of your expectations; your pimples might become worse upon starting
to take Isotretinoin. Hey! Don’t freak out yet!
However, you’ll start to see Accutane results within 7 to 10 days of your
treatment course. Your pimple will start diminishing gradually within the period.
Mostly, full or near-full acne clearing occurs within 16 to 24 weeks of the
treatment course. Once you are through with the course, you’ll highly possibly
remain acne-free for a very long period.
A repeat course is only recommended in cases whereby a definite relapse is
noticed after the treatment course. Nevertheless, a repeat course should only
be started at least 8 weeks after the last day of the previous (initial) course.
This is because acne is likely to improve within that period after the initial
course.
How to use Isotretinoin

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Accutane (Isotretinoin) is available in in oral 10-mg, 20-mg as well as 40-mg
soft gelatin capsules. The elements contained in every capsule of this drug
include beeswax, butylated hydroxyanisole, soybean oil, edetate disodium,
hydrogenated vegetable oil as well as hydrogenated soybean oil flakes.
Each of isotretinoin 10mg, isotretinoin 20mg and isotretinoin 40mg capsule
have different dye systems. Isotretinoin 10mg features iron oxide (red) and
titanium dioxide, 20mg has FD&C Red No. 3, FD and C Blue No. 1, and
titanium dioxide while 40mg has FD&C Yellow No. 6, D&C Yellow No. 10, and
titanium dioxide dye systems.
In layman’s language isotretinoin 10mg comes in light pink color, 20 mg in
maroon, while 40 mg are yellow.
Isotretinoin dosage
Isotretinoin dosage is different for different patients. Therefore, it is important
that you follow your doctor’s prescription of the usage instructions on its label.
The rule of thumb is that your initial isotretinoin dose is dependent on your
body weight, the medical issue for which you are using the drug as well as the
strength of the medicine.
For adults and kids who are at least 12 years old, the average daily dose is 0.5
to 1 milligram (mg) per kilogram (kg) of body weight. Whichever the dose that
your doctor recommends, should be taken with a meal every time.
Isotretinoin dose is taken as two divided doses and a qualified patient should
take it for 15 to 20 weeks. For kids who are younger than 12 years of age, their
dosage must be determined by their doctor.
If your doctor prescribes you a 0.5 mg/kg/day isotretinoin dose, that doesn’t
necessarily mean that you’ll be using that dose throughout the treatment
course. Depending on your response to the drug, especially as far as the
clearing of your cystic acne and the appearance of clinical side effects are
concerned, your doctor can adjust the dose.
Here are the average Isotretinoin 4759-48-2 dosages according to body weight

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Body Weight Total mg/day
Kgs pounds 0.5 mg per kg 1 mg per kg 2 mg per kg*
40 88 20 40 80
50 110 25 50 100
60 132 30 60 120
70 154 35 70 140
80 176 40 80 160
90 198 45 90 180
100 220 50 100 200
However, there’s a special exception to the dose recommendation range.
Adults with severe cystic acne causing scaring or nodular acne mainly
manifested on their backs may need adjustment by a maximum of 2.0
mg/kg/day, depending on their tolerance to myorisan (Isotretinion).
Isotretinoin usage
Accutane (isotretinoin) should be taken with food. It’s advisable that you take
every dose of the drug immediately after a meal or snack to ensure maximum
effectiveness of the medicine.

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Failure to take the drug
with food will reduce its
absorption by the body
significantly. Therefore,
before your doctor adjusts
your dose upwards to
increase the effectiveness
of the drug, you’ll be
questioned about your
compliance with food
instructions.
Also, you should swallow
Accutane capsule whole
without crushing, breaking,
chewing or sucking it.
Besides, you are supposed
to swallow it with a full
glass of water.
A single course of Isotretinion has been proved to result in full or persistent
remission of cystic acne. However, as earlier mentioned, in case your
dermatologist finds it necessary for you to have a second course of treatment,
it should start as from the eighth week after the day the first course ended.
In a study to analyze the effectiveness of the isotretinoin dosages, it was
established that all of them offered initial clearing of acne. However,
retreatment with the lower dosages was found to be safer.
What to avoid while taking isotretinoin
Getting pregnant while taking the medication and within one month after the
end of the treatment course.

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Breastfeeding during the treatment course and within one month after the
course. It is suspected that the drug can pass through your milk and possibly
harm your baby but there’s no scientific evidence to back up the suspicion.
Donating blood while taking the medication and within one month after the
end of the treatment course. If a pregnant woman gets your donated blood, her
baby might be at risk of the side effects of the medication.
Taking other medications or herbal products containing Accutane
(isotretinoin) unless you have your doctor’s approval.
Driving at night in case your night vision has been affected by Accutane
(isotretinoin).
Getting a cosmetic procedure for skin smoothening, while taking Accutane
and six months after the course of the treatment. The procedures include
waxing, dermabrasion, and lasers. The medication may make you more
vulnerable to scarring resulting from these procedures.
Having direct sunlight and ultraviolet light exposure. The medication can
increase your skin’s sensitivity to these lights.
Sharing the drug with other people. As mentioned earlier, the drug should
be taken upon a doctor’s prescription.
Missed Accutane (isotretinoin) dose
In case you miss your myorisan dose, you should take it as soon as you can.
Nevertheless, you’ve remembered about it when it is almost time for your next
dose, just do away with the missed dose and resume your regular dosing
schedule. Take the next dose at the regular time. Don’t take two doses at the
same time or too close to each other.
Special prescribing requirements

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Due to the possible severe side effects of Accutane (isotretinoin), the
marketing of the drug is exclusively done through a special limited distribution
program called iPLEDGE™. The program is approved by Food and Drug
Administration.
The prescribers of the medicine must be registered and activated with this
program- iPLEDGE. Besides, the drug is exclusively for patients who have
been registered with the program and ascertained to have comprehensively
met the requirements of the program.
So, what’s all about iPledge program?
The main aim of iPledge program is to make sure that only the qualified people
take the medication and the possible side effects are kept as minimal as
possible through adherence to the drug’s prescription and strict observance of
the cautionary measures. Things involved in the program include monthly
pregnancy tests and birth control. Talk to your doctor to know more about the
program.
Pregnancy tests
Female patients who can get pregnant are supposed to undergo two urine or
serum pregnancy tests with a minimum sensitivity of 25 mIU/mL. Their results
for both tests must be negative for them to receive their first Accutane
(isotretinoin) prescription.
The initial test is gotten by the specialist prescribing Accutane (isotretinoin)
upon establishing that the acne is qualified for Accutane treatment. The
second test is primarily done to confirm the results of the first test. It is
supposed to be performed in a laboratory with CLIA certification. The period
between the two test shouldn’t be less than 19 days.
In case you are a female cystic acne patient with a regular menstrual cycle, the
second pregnancy test should be performed within the first five days of the
menstrual period which is right preceding the possible start of the of Accutane
(isotretinoin) treatment course. Besides, the test should be done after you
have used two types of contraception for 30 days.
If your menstrual cycle is irregular, or are on a birth control technique that
prevents withdrawal bleeding, the second test should be performed within a
period that immediately precedes the start of Accutane (isotretinoin) course of
treatment. Just as with a woman with a regular menstrual cycle, this test

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should also be done after you have used two types of contraception for 30
days.
You need to understand and strictly follow all the requirements of the iPledge
program. Otherwise, you won’t qualify to get the drug or another prescription of
the medication.
We previously saw that there are numerous isotretinoin brands. Another thing
you ought to know is that different isotretinoin brands work differently. In as
such, capsules of a certain brand of the drug shouldn’t be substituted with any
other form of isotretinoin.
For instance, you shouldn’t substitute Accutane capsules with Absorica
capsules. Therefore, in case you refill your isotretinoin (Accutane) and you find
that it seems different from the initial one, seek clarification from your
pharmacist.
What are the side effects of Accutane
Perhaps at this point you are wondering, “is Accutane safe?” well; in as much
as the drug is an ultra-effective treatment for acne, just like any medicine, it
can result in some side effects. But there’s nothing to worry about Isotretinoin
side effects especially if you follow the prescriptions to the letter and strictly
observe the precautions.
We are going to see more about the precautions (the dos and the don’ts) here
later on.
Another thing that you are supposed to bear in mind about the side effects of
Accutane is that not everyone who takes the medication experiences them (the
undesired effects). Besides, the undesired effects normally go away when you
stop taking the medication.
While some Accutane side effects are common and less severe, others are
rare and more severe. Let’s first look at the common side effects of Accutane.
Common Isotretinoin side effects
The common Isotretinoin side effects include:
 Skin dryness, flaking and itchiness
 skin peeling, particularly on the palms and soles

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 Mouth, nose, and eye dryness
 Chapped lips
 Nosebleeds
 Hair thinning
 Photosensitivity
 Reduced night vision
 Fatigue (extreme tiredness
 Red, cracked and sore lips
Less common side effects of Accutane
Although the following side effects can occur, their occurrences are less
common. In fact, only less than 0.001% of the people who take the drug
experience these serious effects. These effects include:
 Headache
 Painful bones and joints
 Chest and abdominal pain
 Nausea
 Vomiting
 Pain or difficulty while swallowing something
 Diarrhea
 Rectal bleeding
Dry skin and lips are very common side effects. For safety, do not have any
waxing, dermabrasion, or laser skin treatment while you’re taking isotretinoin
for acne and for at least 6 months after you stop, as this could cause scarring
or skin irritation.
 Birth defects
Many people ask, “Is Accutane safe for pregnant women?” The answer is NO;
it isn’t safe at all for pregnant women.
Pregnant women are highly discouraged to use Accutane for acne or cystic
acne treatment or for any purpose whatsoever. Also, women who are likely to
get pregnant during the course of the Roaccutane treatment shouldn’t use the
drug.
The reason for that caution is because the effect of Isotretinoin mechanism of
action, irrespective of the Isotretinoin dosage, can affect the fetus, causing
birth defects. Some of the body organs/parts of the foetus that can be affected

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by abnormalities include the face, brain, heart ears, eyes as well as thymus
and parathyroid glands.
Also, a pregnant woman who takes this medication is at high risk of
spontaneous abortion or premature birth.
If a woman who’s taking Accutane (Isotretinoin) conceives (gets pregnant),
she should stop using the drug immediately and visit an
Obstetrician-Gynecologist who’s experienced with reproductive toxicity.
Although there’s no accurate way in which the specialist can establish if the
unborn child has been affected by Isotretinoin mechanism of action, he/she
can conduct an evaluation to establish the possibility of the same. Besides, the
mother will get counseling to enable her cope with the resulting anxiety and the
possible negative outcomes.
Does Isotretinoin also cause depression?
Depression is the most contentious effect of Isotretinoin. There are some
reports indicating that some people taking the drug experience depression.
However, there’s no scientific evidence linking roaccutane with suicide.

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There’s no one who can really explain how the drug is likely to cause
depression. However, some scientists believe that the medication is likely to
disrupt the production of serotonin as well as the manner in which it is utilized
by the body.
Possibly this sounds scary but there’s no cause for alarm. Reason? The
majority of the people who use Isotretinoin experience any mental issue. In
fact, there no absolute evidence linking the use of Isotretinoin with depression.
Better still; some studies have cast doubt on the possible link between the two.
Nevertheless, as a precautionary measure, in case you have a history of
depression or any other form of mental illness, ensure that you bring it to the
attention of your health specialist before you start taking Isotretinoin. Also, in
case you develop depression symptoms have suicidal thoughts or psychosis
while taking Isotretinoin; don’t hesitate to let your healthcare service provider
know about it.
How to deal with the side effects of Accutane
There are of the things that you can do to address the respective Isotretinoin
side effects:
Isotretinoin side effect How to cope with it
dry skin or lips
Apply a moisturizer (preferably oil-free face
moisturizer for sensitive skin) and a lip
balm on your lips regularly
Reduce your shower time to less than 2
minutes and use lukewarm water instead
of hot
Increased skin sensitivity to light
Stay away from bright sun and apply a high
factor, oil- free sun cream on your skin
even when it’s cloudy. Avoid using a
sunlamp or sunbeds

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Dry eyes
Request your eye specialist to recommend
to you some eye drops. In case you wear
contact lenses and they
feel uncomfortable while taking
Isotretinoin, you can substitute them with
glasses for the period you’ll be taking the
medication.
Dry mouth/throat Chew sugarless gum or sweets.
Headaches
Joint pain
Muscle pain
Request your pharmacist to recommend
you a pain- relieving drug.
Avoid intense exercises as they may
worsen the pain
Is Isotretinoin Safe to Use?
The answer to whether Isotretinoin safe to use can be either yes or no. It
depends on an individual.
First, as earlier mentioned, there are specific conditions (for instance, pregnant
women or those that are likely to conceive) that make some people unfit to use
the drug. If you have these conditions, it won’t be safe for you to use
Isotretinoin
Besides, Isotretinoin is exclusively meant to be taken by people with severe
cystic acne/nodular acne or widespread acne of the back or body that won’t
clear even after taking retinol for acne or any other treatment for acne. In case
your acne is mild, your dermatologist will most likely prescribe you other mild
products with vitamin A for acne or any other medically proved treatment for
acne.

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How to buy Accutane (isotretinoin) online
If are a manufacturer, patient or pharmacist, have met all the requirements of
iPledge program and need to buy isotretinoin, you can simply get it hassle-free
online. However, remember there’s a caveat when it comes to the marketing of
this drug; it should only be sold by iPledge-approved suppliers and
pharmacists.
For you to be legally allowed to distribute or sell isotretinoin, you should first
register with iPLEDGE and also agree to fulfill all the respective requirements
set by the program for isotretinoin product distribution.
Considering the requirements, aasraw.com is the best, most convenient and
place where you can buy isotretinoin effortlessly. We sell genuine raw
isotretinoin and isotretinoin capsules to wholesalers and pharmacists at
competitive prices.
How are you supposed to store Accutane
(isotretinoin)?
Accutane (isotretinoin) should be stored in a sealed container at room
temperature (59° to 86°F, 15° to 30°C). The place that you keep this drug
should be away from heat and direct light and should be moisture-free.
Besides, the drug shouldn’t be frozen and should be kept out of children’s
reach.
Don’t keep this drug if it’s no longer needed or outdated. However, don’t just
dispose using just any way; consult your healthcare specialist for proper
disposal directions.
Isotretinoin Reviews
Let’s now see some Isotretinion reviews from some people who have used the
medication.
Hannah White: “Can’t keep calm! Finally, I have managed to get an acne free
face that I’ve been yearning for years. Since my adolescence 12 years ago, I
had been battling with severe acne. I lost my self-esteem as a result.

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I tried nearly all anti-acne products but none of them managed to get rid of the
pimples. Last year, a friend advised me to try Isotretinoin which I did. I
completed the treatment two months ago and I’m very happy with the results.
My acne has cleared and the black spots are fading away too. I’d definitely
recommend this drug to someone.”
Kelly: I can’t thank whoever came up with isotretinoin for acne. Were it not for
the drug, I’d still be dealing with the severe cystic acne. I’d advise anyone out
there who’s almost giving up on getting an effective cystic acne medication to
visit their doctor and find out if it’s okay for them to use Isotretinoin (Accutane).
This medicine indeed works wonders; I can confidently attest to that.
Juliana: “Although isotretinoin costed me an arm and a leg, I got maximum
value for my money. In fact, I feel like I got more than what I paid for. I’m sure if
I continued to use my usual medications, I’d have spent much more money,
yet without getting the desired outcomes. I strongly recommend Accutane for
acne that has beaten other products with vitamin A for acne. “
Emily Hanson: “wow! Couldn’t be happier with the isotretinoin mechanism of
action and the results. After reading many isotretinoin reviews, I decided to
visit a pharmacist to establish if the drug was suitable for me.
Upon seeing my acne treatment record, he confirmed that the acne could be
treated using isotretinoin as it was severe and persisted for a long period
despite various treatments. I started to see a significant improvement on my
face within the first 10 weeks of the treatment course and by the 20th week,
the acne had cleared completely.”
Billy Harts: I am a licensed and iPledge-approved pharmacist with a drug
located at Illinois. I started selling isotretinoin roughly one year ago and boy…!
This drug is selling like a hotcake. Even with the iPledge requirements, my
patients highly praise it. I’d like to thank aasraw.com for bringing it closer to
me.
Salome Williams: “Don’t mind about isotretinoin cost; this drug is the real deal
for cystic acne treatment. It’s been three years since the time I finished my
isotretinoin treatment course and couldn’t be happier with the results. My acne
has disappeared and I can now step out with confidence. “
Charlene B: The effectiveness of this drug in the fight against severe acne is
unrivaled. I had tried tens of acne treatment products and it’s only isotretinoin

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that managed to set me free from the nuisance. I’m extremely grateful for this
super-drug.
Isotretinoin online
Isotretinoin is beyond any doubt an ultra-effective acne treatment. In case you
have severe cystic acne or a patient with serious cystic pimples that don’t clear
even after taking other acne medications, the drug is highly likely to be a viable
treatment option. However, doctor’s advice is very crucial before one embarks
on taking this medication. Also, the patient and the drug’s distributor must
ensure that they meet all the respective requirements pertaining to the
handling of the medicine.