https://www.aasraw.com/products/crizotinib-powder/
https://www.aasraw.com/ceritinib/
Ceritinib(CAS:1032900-25-6) has been shown to be effective at treating patients whose disease progressed during or shortly after treatment with crizotinib and who currently have very limited treatment options, as well as patients who have not been treated before. Regarding safety, the adverse effects with Ceritinib generally appeared manageable.
Join Fight CRC in a webinar about biomarkers. In this session, Dr. Chris Lieu will focus the discussion on the NTRK biomarker, in addition to ctDNA, and Next-Generation Sequencing.
New drugs for treating multiple types of cancers boc sciencesBOC-Sciences
Recently, at the annual meeting of the American Society of Clinical Oncology at the United States in 2017, researchers from multinational reported and exchanged their latest study results, the most noteworthy of which was the development of new drugs for the treatment of multiple types of cancers. Here, we sort out about this.
Report Back from 2023 San Antonio Breast Cancer Symposium (SABCS)bkling
Curious about the latest information released about Early-Stage Breast Cancer at the annual San Antonio Breast Cancer Symposium? To help explain it all, we are thrilled to have Dr. Sherry Shen, medical oncologist and clinical investigator on the Breast Medicine Service at Memorial Sloan Kettering Cancer Center (MSK), as our presenter. Join us to hear about the different sessions and data that were presented at SABCS.
Join Fight CRC in a webinar about biomarkers. In this session, Dr. Chris Lieu will focus the discussion on the NTRK biomarker, in addition to ctDNA, and Next-Generation Sequencing.
New drugs for treating multiple types of cancers boc sciencesBOC-Sciences
Recently, at the annual meeting of the American Society of Clinical Oncology at the United States in 2017, researchers from multinational reported and exchanged their latest study results, the most noteworthy of which was the development of new drugs for the treatment of multiple types of cancers. Here, we sort out about this.
Report Back from 2023 San Antonio Breast Cancer Symposium (SABCS)bkling
Curious about the latest information released about Early-Stage Breast Cancer at the annual San Antonio Breast Cancer Symposium? To help explain it all, we are thrilled to have Dr. Sherry Shen, medical oncologist and clinical investigator on the Breast Medicine Service at Memorial Sloan Kettering Cancer Center (MSK), as our presenter. Join us to hear about the different sessions and data that were presented at SABCS.
Current concepts in the pathogenesis of cancer /certified fixed orthodontic c...Indian dental academy
Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
6 questions about afatinib on anti caners(nsclc)AASraw
https://www.aasraw.com/afatinib-on-anti-caners/
https://www.aasraw.com/products/afatinib/
Afatinib powder, sold under the brand name Gilotrif among others, is a medication used to treat non-small cell lung carcinoma (NSCLC).It belongs to the tyrosine kinase inhibitor family of medications.It is taken by mouth.
Biomarkers and biomarker testing are changing the way some colorectal cancer is treated and knowing your biomarkers can help your doctors identify your best treatment options and help you in making well informed decisions about how your cancer will be treated allowing you to be your own best advocate.
Join in on this informative webinar with guest Dr. Christopher Lieu from the University of Colorado Cancer Center, as he discusses everything you need to know about biomarkers.
Developmental study of Ibrutinib (anti-cancer Drug) by mominul islamMd. Mominul Islam
Ibrutinib ,FDA approved (2013) anticancer drug.Ibrutinib (Imbruvica) is a small molecule drug that binds permanently to a protein, Bruton's tyrosine kinase (BTK), that is important in B cells , the drug is used to treat B cell cancers like mantle cell lymphoma, chronic lymphocytic leukemia.
In this webinar, Dr. Azad discusses colorectal cancer recurrence. She addresses things to do to help reduce the risk of recurrence, in addition to what steps should be taken if colon or rectal cancer returns.
Molecular testing and tumor testing. Have you ever been asked about it? Have you wondered the importance of it, as it relates to your particular cancer? Have you ever wondered if you should or shouldn't have your tumor tested, and what that involves? Dr. Bekaii-Saab, MD will discuss the importance of testing the molecular biology of an individual patients tumor. How they do that and why it may or may not be important to have done. He will talk about how this is playing an even bigger role in choice of treatment options for patients now more than ever. And about the way physicians are making treatment choices based on each individuals molecular biology of their tumor.
Dr. Bekaii-Saab is the Section Chief, Gastrointestinal Oncology, James Cancer Hospital and Solove Research Institute. Dr. Bekaii-Saab is one of America’s Best Doctors. Additionally, he has been listed in U.S. News and World Report’s Top Doctors for multiple consecutive years. His research interests include experimental therapeutics/translational research focused on molecularly-targeted and immune-mediated therapies in gastrointestinal (GI) cancers. He is the principal investigator on numerous clinical trials, including studies supported through research grants from the National Cancer Institute (NCI) and the National Comprehensive Cancer Network (NCCN). Dr. Bekaii-Saab is the recipient of the prestigious NCI clinical investigator team leadership award and the ASCO leadership program development award.
Dostarlimab JEMPERLI is a PD 1 monoclonal antibody for the treatment of adult patients, with mismatch repair deficient dMMR , recurrent or advanced endometrial cancer that has progressed on or following prior therapy with a platinum containing regimen. As determined by an FDA approved test this indication was granted rapid approval based on the rate of tumor response and the duration of the response. Continued approval for this indication is conditioned on further confirmatory trials demonstrating and documenting clinical benefit. In June 2022, the clinical trial NCT04165772 reported a 100 remission rate for rectal cancer. This clinical trial brought proof that we can match a tumor and the genetics of what is driving it, with therapy. This clinical trial continues to enroll patient and is currently enrolling patients with gastric, prostate, and pancreatic cancers. Dostarlamib is being recommended for rectal cancer. The focus of this review is to summarize the existing knowledge regarding Dostarlimab and explore the possibilities of mono and combination therapies. Tanuja Shaikh | Snehal Pawar | Mr. Arpit Rajaram Suralkar "Dostarlimab as an Anticancer" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-6 , October 2022, URL: https://www.ijtsrd.com/papers/ijtsrd52167.pdf Paper URL: https://www.ijtsrd.com/pharmacy/pharmacology-/52167/dostarlimab-as-an-anticancer/tanuja-shaikh
Lo que un reumatólogo debe saber sobre immunoterapia del cáncerMauricio Lema
FORO ARTE 2019, 22/03/2019
-- Flagship: toda la información que consideré pertinente (217 diapositivas).
-- La presentación de la conferencia en sí se basa en este repositorio
Dr. Dustin Deming led us through a discussion on the latest research and treatments for colorectal cancer patients presented at the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.
A few of the topics covered include research on immunotherapy and trials studying:
– MSI-H (review of the Anti-PD-1 trial)
– HER2 amplification
– BRAF mutations
For more updates on colorectal cancer research, visit our blog: http://fightcolorectalcancer.org/category/research-treatment/
An depth look about 17alpha-methyltestosterone uses in Tilapia sex reversal.pdfAASraw
17alpha-Methyltestosterone is a versatile synthetic androgen and anabolic steroid with applications ranging from medical treatments to bodybuilding and aquaculture. In medicine, it helps treat hormone deficiencies and specific cancers. In non-medical contexts, it is used illicitly for enhancing athletic performance. In aquaculture, it plays a crucial role in producing all-male fish populations to optimize growth and productivity.
The Golden Rule of Post-Cycle Therapy (PCT) in bodybuilding.pdfAASraw
Post Cycle Therapy (PCT) is a crucial phase for bodybuilders and athletes who use anabolic steroids or other performance-enhancing drugs (PEDs) to restore their natural hormonal balance after a cycle. PCT products aim to mitigate the suppression of natural testosterone production, prevent muscle loss, and reduce the risk of side effects such as gynecomastia and mood swings. Key PCT products include Selective Estrogen Receptor Modulators (SERMs) like Clomiphene Citrate (Clomid) and Tamoxifen (Nolvadex), which stimulate the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) to boost natural testosterone production and block estrogen receptors, respectively. Aromatase inhibitors (AIs) such as Anastrozole and Letrozole are used to prevent the conversion of testosterone to estrogen, maintaining higher testosterone levels and minimizing estrogen-related side effects. Human Chorionic Gonadotropin (HCG) is sometimes used to directly stimulate testosterone production.
https://www.aea.ltd/post-cycle-therapy-pct-in-bodybuilding/
Current concepts in the pathogenesis of cancer /certified fixed orthodontic c...Indian dental academy
Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
6 questions about afatinib on anti caners(nsclc)AASraw
https://www.aasraw.com/afatinib-on-anti-caners/
https://www.aasraw.com/products/afatinib/
Afatinib powder, sold under the brand name Gilotrif among others, is a medication used to treat non-small cell lung carcinoma (NSCLC).It belongs to the tyrosine kinase inhibitor family of medications.It is taken by mouth.
Biomarkers and biomarker testing are changing the way some colorectal cancer is treated and knowing your biomarkers can help your doctors identify your best treatment options and help you in making well informed decisions about how your cancer will be treated allowing you to be your own best advocate.
Join in on this informative webinar with guest Dr. Christopher Lieu from the University of Colorado Cancer Center, as he discusses everything you need to know about biomarkers.
Developmental study of Ibrutinib (anti-cancer Drug) by mominul islamMd. Mominul Islam
Ibrutinib ,FDA approved (2013) anticancer drug.Ibrutinib (Imbruvica) is a small molecule drug that binds permanently to a protein, Bruton's tyrosine kinase (BTK), that is important in B cells , the drug is used to treat B cell cancers like mantle cell lymphoma, chronic lymphocytic leukemia.
In this webinar, Dr. Azad discusses colorectal cancer recurrence. She addresses things to do to help reduce the risk of recurrence, in addition to what steps should be taken if colon or rectal cancer returns.
Molecular testing and tumor testing. Have you ever been asked about it? Have you wondered the importance of it, as it relates to your particular cancer? Have you ever wondered if you should or shouldn't have your tumor tested, and what that involves? Dr. Bekaii-Saab, MD will discuss the importance of testing the molecular biology of an individual patients tumor. How they do that and why it may or may not be important to have done. He will talk about how this is playing an even bigger role in choice of treatment options for patients now more than ever. And about the way physicians are making treatment choices based on each individuals molecular biology of their tumor.
Dr. Bekaii-Saab is the Section Chief, Gastrointestinal Oncology, James Cancer Hospital and Solove Research Institute. Dr. Bekaii-Saab is one of America’s Best Doctors. Additionally, he has been listed in U.S. News and World Report’s Top Doctors for multiple consecutive years. His research interests include experimental therapeutics/translational research focused on molecularly-targeted and immune-mediated therapies in gastrointestinal (GI) cancers. He is the principal investigator on numerous clinical trials, including studies supported through research grants from the National Cancer Institute (NCI) and the National Comprehensive Cancer Network (NCCN). Dr. Bekaii-Saab is the recipient of the prestigious NCI clinical investigator team leadership award and the ASCO leadership program development award.
Dostarlimab JEMPERLI is a PD 1 monoclonal antibody for the treatment of adult patients, with mismatch repair deficient dMMR , recurrent or advanced endometrial cancer that has progressed on or following prior therapy with a platinum containing regimen. As determined by an FDA approved test this indication was granted rapid approval based on the rate of tumor response and the duration of the response. Continued approval for this indication is conditioned on further confirmatory trials demonstrating and documenting clinical benefit. In June 2022, the clinical trial NCT04165772 reported a 100 remission rate for rectal cancer. This clinical trial brought proof that we can match a tumor and the genetics of what is driving it, with therapy. This clinical trial continues to enroll patient and is currently enrolling patients with gastric, prostate, and pancreatic cancers. Dostarlamib is being recommended for rectal cancer. The focus of this review is to summarize the existing knowledge regarding Dostarlimab and explore the possibilities of mono and combination therapies. Tanuja Shaikh | Snehal Pawar | Mr. Arpit Rajaram Suralkar "Dostarlimab as an Anticancer" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-6 , October 2022, URL: https://www.ijtsrd.com/papers/ijtsrd52167.pdf Paper URL: https://www.ijtsrd.com/pharmacy/pharmacology-/52167/dostarlimab-as-an-anticancer/tanuja-shaikh
Lo que un reumatólogo debe saber sobre immunoterapia del cáncerMauricio Lema
FORO ARTE 2019, 22/03/2019
-- Flagship: toda la información que consideré pertinente (217 diapositivas).
-- La presentación de la conferencia en sí se basa en este repositorio
Dr. Dustin Deming led us through a discussion on the latest research and treatments for colorectal cancer patients presented at the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.
A few of the topics covered include research on immunotherapy and trials studying:
– MSI-H (review of the Anti-PD-1 trial)
– HER2 amplification
– BRAF mutations
For more updates on colorectal cancer research, visit our blog: http://fightcolorectalcancer.org/category/research-treatment/
An depth look about 17alpha-methyltestosterone uses in Tilapia sex reversal.pdfAASraw
17alpha-Methyltestosterone is a versatile synthetic androgen and anabolic steroid with applications ranging from medical treatments to bodybuilding and aquaculture. In medicine, it helps treat hormone deficiencies and specific cancers. In non-medical contexts, it is used illicitly for enhancing athletic performance. In aquaculture, it plays a crucial role in producing all-male fish populations to optimize growth and productivity.
The Golden Rule of Post-Cycle Therapy (PCT) in bodybuilding.pdfAASraw
Post Cycle Therapy (PCT) is a crucial phase for bodybuilders and athletes who use anabolic steroids or other performance-enhancing drugs (PEDs) to restore their natural hormonal balance after a cycle. PCT products aim to mitigate the suppression of natural testosterone production, prevent muscle loss, and reduce the risk of side effects such as gynecomastia and mood swings. Key PCT products include Selective Estrogen Receptor Modulators (SERMs) like Clomiphene Citrate (Clomid) and Tamoxifen (Nolvadex), which stimulate the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) to boost natural testosterone production and block estrogen receptors, respectively. Aromatase inhibitors (AIs) such as Anastrozole and Letrozole are used to prevent the conversion of testosterone to estrogen, maintaining higher testosterone levels and minimizing estrogen-related side effects. Human Chorionic Gonadotropin (HCG) is sometimes used to directly stimulate testosterone production.
https://www.aea.ltd/post-cycle-therapy-pct-in-bodybuilding/
What are the top peptides for bodybuilding.pdfAASraw
Peptides are short chains of amino acids, the building blocks of proteins, that play crucial roles in various physiological functions. Peptides work by stimulating the release of growth hormone (GH) from the pituitary gland, which in turn promotes muscle growth and repair. They can also increase protein synthesis, improve metabolism, and reduce inflammation, leading to better overall body composition and performance.
In bodybuilding, peptides are popular for their ability to enhance muscle growth, aid in fat loss, and improve recovery. They are more specific in their actions compared to traditional steroids, which means they can target specific goals like muscle growth or fat loss with fewer side effects. Peptides also have a shorter half-life, allowing for more precise dosing and minimizing the risk of detection in drug tests. Overall, peptides offer bodybuilders a safe and effective way to enhance their physique and performance.
https://www.aea.ltd/product/bpc-157/
BPC-157 is a synthetic peptide that has shown potential therapeutic benefits in promoting tissue healing and regeneration. It may be used for wound healing, including skin, muscle, tendon, and bone injuries. Additionally, it has been studied for its potential effects on gastrointestinal healing, joint and bone health, and its anti-inflammatory properties.
Healing Marvel: Harnessing TB500's Multifunctional Powers for Rapid RecoveryAASraw
TB500 emerges as a remarkable therapeutic agent with multifaceted properties that hold immense promise for healing and recovery. Its ability to enhance tissue regeneration, reduce inflammation, and promote angiogenesis makes it a potent tool in the realm of medical interventions. From wound healing and tissue repair to musculoskeletal injuries and chronic conditions, TB500 showcases its versatile nature. Furthermore, its potential to improve cardiovascular health and aid in neuroprotection further expands its scope of applications. While further research is necessary to fully understand its mechanisms and optimize its clinical use, TB500 undoubtedly stands as a beacon of hope for patients seeking accelerated healing and improved outcomes.
Exploring the Benefits and Risks of Melanotan II A Comprehensive Overview .pdfAASraw
The tanning benefits of MT-II are desirable to individuals who want to achieve a sun-kissed look without prolonged sun exposure. By using MT-II, individuals can achieve a tan quickly and conveniently, regardless of their access to sunlight or their skin's natural ability to tan. MT-II offers an alternative to traditional tanning methods, such as sunbathing or using tanning beds, and provides greater control over the tanning process.
How does Vardenafil HCL Powder compare to similar sex enchaner powder.pdfAASraw
Vardenafil and tadalafil are both medications used to treat erectile dysfunction (ED) in men. While both drugs are similar in many ways, there are a few differences that may make one more suitable for some men than the other.
One unique benefit of vardenafil is its faster onset of action. Vardenafil typically starts working within 15-30 minutes of taking it, while tadalafil can take up to 30-60 minutes to take effect. This faster onset of action may be beneficial for men who want to be spontaneous with their sexual activity.
Another potential advantage of vardenafil is that it may be less likely to cause certain side effects than tadalafil. For example, some men report experiencing less back pain and muscle aches with vardenafil than with tadalafil.
On the other hand, #tadalafil has a longer duration of action than vardenafil. While vardenafil typically lasts for 4-5 hours, tadalafil can last for up to 36 hours. This longer duration of action may be beneficial for men who want more flexibility in their sexual activity and do not want to worry about taking a pill every time they want to have sex.
https://www.aasraw.com/products/vardenafil-hydrochloride-levitra-powder/
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Special Issue:What hormones are typically used for fish sex reversal Version ...AASraw
Fish sex reversal is an important technique used in aquaculture to produce all-male populations for faster growth and improved disease resistance.
Revised version of last article.
Special Issue:What hormones are typically used for fish sex reversal.pdfAASraw
Male fish are generally heavier and grow faster than female fish. Therefore, in order to ensure the supply of fish meat to the greatest extent, people use sex control technology to increase the yield and variety of fish under the premise of ensuring that exogenous hormones are harmless to the human body.
The most discussed topic on cbd powder oils(1)AASraw
https://www.aasraw.com/products/cannabidiol/
https://www.aasraw.com/products/cbd/
CBD, short for cannabidiol, is a chemical compound from the Cannabid sativa plant. Two of the compounds in marijuana are delta-9 tetrahydrocannabinol (THC) and CBD. These compounds have different effects.
https://www.aasraw.com/products/azd-9291/
AZD-9291 powder is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that binds to certain mutant forms of EGFR (T790M, L858R, and exon 19 deletion) that predominate in non-small cell lung cancer (NSCLC) tumours following treatment with first-line EGFR-TKIs.
Top 7 drugs for treating lung cancer approved by fdaAASraw
https://www.aasraw.com/lung-cancer-drugs/
Many patients with lung cancer choose drug therapy in the early stage, because it is the most direct and simple way to control the spread of cancer cells. The following drugs are commonly used to treat lung cancer(SCLC and NSCLC).
https://www.aasraw.com/products/cannabidiol/
https://www.aasraw.com/products/cbd/
CBD, short for cannabidiol, is a chemical compound from the Cannabid sativa plant. Two of the compounds in marijuana are delta-9 tetrahydrocannabinol (THC) and CBD. These compounds have different effects.
https://www.aasraw.com/products/erlotinib/
https://www.aasraw.com/using-erlotinib/
Erlotinib Powder, sold under the brand name Tarceva among others, is a medication used to treat non-small cell lung cancer (NSCLC) and pancreatic cancer. Specifically it is used for NSCLC with mutations in the epidermal growth factor receptor (EGFR) — either an exon 19 deletion (del19) or exon 21 (L858R) substitution mutation — which has spread to other parts of the body.
#Erlotinib,
https://www.aasraw.com/anti-cancer-drugs-acalabrutinib/
https://www.aasraw.com/products/acalabrutinibacp-196/
Acalabrutinib powder, also known as ACP-196, is a novel irreversible second-generation Bruton’s tyrosine kinase (BTK) inhibitor, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway and that, was rationally designed to be more potent and selective than ibrutinib.
Cabozantinib success stories on treating canerAASraw
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Cabozantinib Powder, sold under the brand names Cometriq and Cabometyx, is a medication used to treat medullary thyroid cancer, renal cell carcinoma, and hepatocellular carcinoma. It is a small molecule inhibitor of the tyrosine kinases c-Met and VEGFR2, and also inhibits AXL and RET. It was discovered and developed by Exelixis Inc.
Clomiphene citrate raw powder is it possible to get pregnancy fast by clomiph...AASraw
https://www.aasraw.com/is-it-get-fast-by-clomiphene/
Clomiphene citrate powder is a non-steroidal fertility medicine. It causes the pituitary gland to release hormones needed to stimulate ovulation (the release of an egg from the ovary).
https://www.aasraw.com/products/yohimbine-hcl-powder/
https://www.aasraw.com/what-is-yohimbine-and-how-it-works/
Yohimbine HCL powder is an alpha-blocker. It works by increasing certain chemicals in the body, which dilate the pupils of the eye. It also dilates blood vessels and increases blood flow in the penis, which helps to improve erectile function. And its subset yohimbine, are fat-burning compounds, primarily used to lose fat during short term fasting.
https://www.aasraw.com/products/adrafinil-powder/
Adrafinil powder has gained popularity in recent years due to its similarity to modafinil and relative accessibility. Adrafinil powder is treated like a dietary supplement in the United States in that you can buy it without a prescription.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Ceritinib History and Uses
Ceritinib Was Approved For Using in EU
Ceritinib(CAS:1032900-25-6) has been shown to be effective at treating patients whose disease
progressed during or shortly after treatment with crizotinib and who currently have very limited
treatment options, as well as patients who have not been treated before. Regarding safety, the
adverse effects with Ceritinib generally appeared manageable.
The European Medicines Agency therefore decided that Ceritinib’s benefits are greater than its
risks and recommended that it be approved for use in the EU.
Ceritinib was originally given ‘conditional approval’ because there was more evidence to come
about the medicine. As the company has supplied the additional information necessary, the
authorisation has been switched from conditional to full approval.
You must be curious about this product, Let us read more infromation about Ceritinib:
Ceritinib Description
Ceritinib is used for the treatment of adults with anaplastic lymphoma kinase (ALK)-positive
metastatic non-small cell lung cancer (NSCLC) following failure (secondary to resistance or
intolerance) of prior crizotinib therapy. About 4% of patients with NSCLC have a chromosomal
rearrangement that generates a fusion gene between EML4 (echinoderm microtubule-associated
protein-like 4) and ALK (anaplastic lymphoma kinase), which results in constitutive kinase
activity that contributes to carcinogenesis and seems to drive the malignant phenotype.
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Ceritinib exerts its therapeutic effect by inhibiting autophosphorylation of ALK, ALK-mediated
phosphorylation of the downstream signaling protein STAT3, and proliferation of ALK-dependent
cancer cells. Following treatment with crizotinib (a first-generation ALK inhibitor), most tumours
develop drug resistance due to mutations in key “gatekeeper” residues of the enzyme. This
occurrence led to development of novel second-generation ALK inhibitors such as ceritinib to
overcome crizotinib resistance. The FDA approved ceritinib in April 2014 due to a surprisingly
high response rate (56%) towards crizotinib-resistant tumours and has designated it with orphan
drug status.
How Does Ceritinib Work For Treating
NSCLC?
Ceritinib is a selective and potent inhibitor of anaplastic lymphoma kinase (ALK). In normal
physiology, ALK functions as a key step in the development and function of nervous system
tissue. However, chromosomal translocation and fusion give rise to an oncogenic form of ALK
that has been implicated in progression of NSCLC. Ceritinib thus acts to inhibit this mutated
enzyme and stop cell proliferation, ultimately halting cancer progression.Because ceritinib is
considered a targeted cancer therapy, an FDA-approved test is required to determine which
patients are candidates for ceritinib. This test, developed by Roche, is the VENTANA ALK (D5F3)
CDx Assay and is used to identify ALK-positive NSCLC patients who would benefit from
ceritinib treatment.
How About Ceritinib Medical Uses?
Ceritinib(LDK378) is a drug used to treat non-small cell lung cancer that has spread to other parts
of the body and is anaplastic lymphoma kinase (ALK) positive. It is also being studied in the
treatment of other types of cancer. Ceritinib blocks the protein made by the ALK gene. Blocking
this protein may stop the growth and spread of cancer cells. Ceritinib is a type of tyrosine kinase
inhibitor.
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How To Storage Ceritinib(LDK378)?
Keep Ceritinib(LDK378) in the container it came in, tightly closed, and out of reach of children.
Store it at room temperature and away from light, excess heat and moisture (not in the bathroom).
Unneeded medications should be disposed of in special ways to ensure that pets, children, and
other people cannot consume them. However, you should not flush Ceritinib(LDK378) down the
toilet. Instead, the best way to dispose of your medication is through a medicine take-back
program. Talk to your pharmacist or contact your local garbage/recycling department to learn
about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website
for more information if you do not have access to a take-back program.
It is important to keep all medication out of sight and reach of children as many containers (such
as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not
child-resistant and young children can open them easily. To protect young children from
poisoning, always lock safety caps and immediately place the medication in a safe location – one
that is up and away and out of their sight and reach.