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SCOPEOF
CHEMISTRY
AFTER B.Sc.
1
Dr.Gurumeet C Wadhawa
Assistant Professor ,Department of
Chemistry
Rayat Shikshan Santa's Veer Wajekar Asc
College,Phunde
Chemistry is that physical science which
includes the study of a range of matters
such as atoms, crystals, molecules and
many other collections of matters
whether they are in isolation or in
combination.
2
3
 Some of the higher study options after B.Sc
Chemistry are
-M.Sc. Chemistry
-M.Sc.Analytical Chemistry
-M.Sc. Drug Chemistry
-M.Sc. Organic Pharmaceutical Chemistry
-M.Sc. Physical &Materials Chemistry
- M.Sc. By Research
-Master of BusinessAdministration (MBA)
- Ph.D in Chemistry
Scope for Higher Studies after
B.Sc Chemistry
4
 Analytical Chemist
 Biomedical Chemist
 Production Officer Quality Controller
 Associate Industrial Research Scientist
 Lab Chemist
 Materials Technologist
 Production Chemist
 Chemical Engineering
 R&D Director
 Research & Development Manager
 Safety Health And Environment Specialist
 Teacher 5
The employment areas for the B.Sc
Chemistry graduates include
pharmaceutical industries, chemical
manufacturers, Forensic Science
Department, plastic industries,
agrochemical industries, etc. Apart from
these, they are also recruited in other fields
such as oil, gas and power sectors and
even in defence services.
6
TOPPh.D. Institutes in India.
 National Chemical Laboratory , Pune
 IISER, Pune
 IISER, Bhopal
 National Institute of Chemical Technology, Hyderabad.
 Indian Institute of Science , Bangalore
 IIT , Bombay
 IIT , Chennai
 IIT, Kanpur
 Institute of Chemical Technology , Mumbai.
 Research Institutes affiliated to University.
7
Government Jobs in Chemistry
• UPSC www.upsconline .nic.in
• MPSC www.mpsconline .gov.in
• Forensic recruitment , Lecturer for gov Colleges
for NET & Non NET candidates.
• ONGC www.ongcindia.com form are
continuethrough our the year.
• NTPC www. Ntpccareers.net Various post in
NTPC.
• Geoscientist post for Chemistry and Lecturer post.
8
SCOPE, Other Than Traditional :-
• Scientist, Science communicator
• Substantiality Manager.
• Fragrance Chemist.
• Favourist & innovation Director
• Application Chemist
• Organic Skincare & Cosmetic Range
• Substantiality Consultant
• Environmental Chemist.
 9
Indian ChemicalIndustry
1
Indian Chemical Industry plays a major role in the overall
development of India
Contributes significantly to India’s economy under
manufacturing sector
It accounts for approximately 7% of India’sGDP.
Output value in the year 2012-13 was 782,949crores
Indian chemical Industry is 6thin the world and 3rdinAsia
India’s exports of chemicals (excluding pharma) was 32.02
US$billion in 2013, and imports US$46.01
Chemical industry growth rate of over 8-11% p.a.and
expected to reach $290billion by 2017
Chemicalindustries- Category
1
The chemical industries broadly categorised;
Basic inorganic & Organic chemicals
Specialty chemicals & fine chemicals
Petrochemicals & plastics,
Pesticides & Agrochemicals,
Fertilizers
Dyes & pigments
Paints & varnishes,
Soaps, perfumes & toiletries and
Pharmaceuticals and others
IndianPharmaceutical industry- overview.
1
Indian pharmaceutical industry is growing fast as
like IT industry.
Manufactures Quality Medicines at affordable cost.
Significant growth is from 1990’s
Market size is about 2 lakhscrore
It is 3rdlargest in the world by volume (10%) and13th
largest (~ 3%) inthe world in term of value.
Growing at around 15-20% (6-8% in global).
Expected grow and reach US$100 billion by2025.
Indian Pharmaceutical industry
1
More than 90% of drugs used in India are
produced in India
The industry is quite fragmented and comprises of
nearly 10,500 companies and majority of them in
the small sector.
Around 300-400 are organized companies
categorized as medium & large
Direct employment is 5lacs and total
employment could be over 20lacs
Mostly located in Maharashtra, Gujarat,
Telungana , AP, HP, Tamil nadu.
* AmongfastestgrowingIndustries:The IPI(Indian
Pharmaceutical Industry) revenue is expected to
expand at a CAGRof 17.8 % during 2008-16 andreach
USD36 billion
* Rapidgrowinghealthcare sector:By 2015, the
healthcare sector is expected to reach USD100 billion
from the current USD65billion.
* GrowingGenericMarket:The generic market is
expected to grow to USD26.1 Billion by 2016 from
current USD11.3 billion in 2011; India genericsMarket
has immense potential for growth
th
7
Export Indian PharmaIndustry
15
India competing with developed countries
due to lower manufacturing cost with better
Quality.
India import was huge and higher than the
export until late 1980s,
Since 1990 export starts growing ,now
export is 5 times higher thanimport.
Export is 50% of the total turnover.
Exported to >200 countries for both
developed and developing countries.
Around 25% of export is toUSA.
20% of the total volume of global generics
ie 1 in 5of Generic * is from India.
*Genericmedicines, andto low-cost versions of newly-developed medicines
Highlightsof Indian Pharma Industry
02/25/16 16
In 2001, CIPLAwas in limelight, offered an AIDSdrug to for
the price of $300 against $12,000 inUS.
India manufactures 30% of the world requirement ofAnti-
HIVdrugs
key contributor to the WHOPrequalification Programme
(PQP) 65-70%
AIDS,Tuberculosis, Malaria, Reproductive Health, and etc...
2012, NATCOgot approval to sell kidney-cancer drug
Nexavar at 3% of market price under compulsorylicense.
CostRs.8500against Rs.2.8 lakh
Advantageof Indian Pharma Industries
02/25/16 17
Global consumption of :The USaccounts for 40-45%, EUis about 20-
24% and Japan15%; balance is rest of world
So target market is US,EU& BRICS.
India is the highest USDMFapproved country outside theUS
India accounts for 30.3 per cent (2,911) of 9619 Drug Master Files
(DMFs) filed with USA,which is the highest outside of USA.
584 manufacturing sites approved by USFDAand next is Italy (<200)
Several Indian Pharmaceutical companies set up plants in abroad
Fast growth in R&Dactivities.
SS The effects in new product patent
SS Price control in the drugs
SS Reformation in the regulatory
SS Developments in the infrastructure
SS Quality Management concept
SS Conforming the global standards
The other challenges include:
* Decline in the production
* Reducer in Drug Approvals
* Stringent regulations
02/25/16 11
GrowthPotential: Opportunity
19
Indian Pharma industry posses several strengths;
Innovation and process design- to copy cat generic.
Strong R&Dcapability,
Qualified personnel
Abundant skilled man power
Around 270 large R& Dbased pharma companies in
India.
Past track is capable of producing better quality drugs
with lower manufacturing cost.
Knowledgeable and Skilled man power (Research,
analytical, regulatory, clinical and IT)
Research& Development:
20
Indian Pharma companies spent huge amount for R&D.
Dr.Reddy’s, SunPharma, Gleanmark are investing in
discovery research
Several companies involved in process development and
contract research.
US$300bn worth of Patent drugs expiries by 2017.
Global R&Dcost is estimated as USD65bn
Contract Research
TopIndian Pharmaceutical companies
1. Sun Pharma
2. Dr. Reddy's Labs
3. Cipla
4. GSK
5. Strides
6. Lupin
7. Aurabindo
8. Wockhardt
9. Zydas Cadila
10. NATCO
11. Orchid
12. IPCA
13. Biocon
14. Torrent
15. Shasun
16. Alambic etc
14
02/25/16
WorldT
opPharma Companies
22
Company Sales R&DExpense
1. Novartis $57,996 ($9946)
2. Pfizer $45,708 $8,393
3. Sanofi $41,047 $5,863
4. Roche $37,082 $9,006
5. Merck $36,042 $7,180
6. Johnson & Johnson $32,313 $6,213
7. GlaxoSmithKline $30,806 $5,693
8. AstraZeneca $26,095 $5,579
9. Gilead Sciences $24,890 $2,854
10. Teva $20,272 $1,488
Basedon 2014 Sales, in $U.S.Millions
Ref:Contract pharma
Money spentfor healthcare
02/25/16 23
8 – 12 years
Drug Discovery is becoming more time and cost consuming…
Drug discovery process :
02/25/16 24
Clinicalstudy:
02/25/16 25
Aclinical trial is a tool for testing a drug,
medical device, or technique for safety
and efficacy.
Global clinical trial market is ~USD 60bn.
Money involved for new drug min is USD
600-mn 2bn out of this 150-200mn spent
for clinical trials
India will make it with 50-60% of cost
and faster.
The advantages are, technical resources
(physician, nurses, and other technical
personals), having developed IT
infrastructure, protection on IPRrelated
issues and etc.
JobOpportunities
26
Pharma is knowledge based industry
Special skills are required to work
Offers excellent salary ,benefits & scope for growth.
Jobopportunities for Chemistry / pharmacy
graduates / pharmaceutical Technology/ Doctors
Government & private sector
JobOpportunities
 Government& Public sector:
 State & Central Govt
 Public sector
 National Labs
 Drug testing
 Research & Development
 NIPER,CSIR, CDRL
27
JobOpportunities in PharmaIndustry
02/25/16 28
Functions/Aactivities :
Marketing & Sales –Technical
Manufacturing/production
Environment management
Research & Development
Quality control & Quality assurance
Regulatory Affairs & IPR
Clinical trials
Testing laboratories- private
Manufacturing/production:
29
Knowledge & Skill required:
Process Chemistry
Technology transfer
Chemical reaction
Handling of Chemicals
Unit operations
Reaction, distillation,
filtration, drying, blending
Formulation, etc
Research&
Development
30
Knowledge & Skill required:
Synthesis- all kind of organic
reaction
Process chemistry
Thermo chemistry
Kinetics
Structure elucidation
Patent search
New analytical techniques
Simple & easy test methods
QualityAssurance& Regulatory
02/25/16 31
Quality Assurance & Regulatory functions
Pharma industries governed by stringent Rules&
regulations
Drugs & Cosmetic Act
Quality system
Good Manufacturing Practice (GMP)
Documents for each activities
Rules & Regulations as per exporting countries
Regulatory Inspection and approvals
Testing/Quality Control
25
Knowledge & Skill required for QCfunctions
Analytical technique
Chromatography
Spectrophotometry
Chiral testing- Optical rotation
Particle size
Dissolution
Inorganic impurity -Residue on
ignition
Crystal structure- XRD
Thermal properties - TGA/ DSC-
Melting point
02/25/16 26
Simpleinstruments for testing
34
pH meter
Conductivity meter
Polarimeter
Refractometer
Titrator
Particle size
Dissolution apparatus
Etc…
Spectroscopy
35
Theory, instrumentation and application
UV-Visible spectrophotometer
FT-IR Spectrum
Mass spectrophotometer
NMR
AAS/ ICP-AESor OES
XRD
Chromatography
36
Extensively used technique is
Chromatography for testing
of purity and impurity in
complex molecule;
TLC
Gas Chromatography
HPLC
Gel permeation
Ion chromatography
T
esting
37
Drugs are tested for :
Purity
Impurities
Structure confirmation –IR,UV
Specific rotation
Loss on drying/ water
Residue of Ignition(inorganic)
Dissolution
Drug release
Stability
RegulatoryAffairs
38
Technical writing
Rules & regulation of various countries
Basic chemistry
Basics of Process & testing
Computer knowledge & communication
Preparedness
39
Over 15 years, employment potential couldrange
between 8-9 million jobs.
Education & training
Instrumentation course
Diploma in pharmaceutical course
Personal development
Interview skill
Reference:
40
Annual report 2014-15 & Chemicals & petrochemicals statistics AT AGLANCE:
2014 govt of india, ministry of chemicals &fertilizers
INDIANCHEMICALINDUSTRY:Five year plan –2012-2017
The pharmaceutical industry and Global health facts and Figures 2014: IFPMA
India Pharma summit 2014-15 position paper; dept of pharmaceuticals, govt of
india
India Chem 2014 :Spurting the growth of Indian Chemical Industry: FICCI
ABrief report of Indian pharmaceutical industry InIndia- ASA Associates
India PharmaInc.Gearing up for the next level of growth PWC
Fromvisionto decisionPharma 2020- PWC
Profile of pharmaceutical industry- Chapter –iv
Wikipedia

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Carrier in chemistry.pptx

  • 1. SCOPEOF CHEMISTRY AFTER B.Sc. 1 Dr.Gurumeet C Wadhawa Assistant Professor ,Department of Chemistry Rayat Shikshan Santa's Veer Wajekar Asc College,Phunde
  • 2. Chemistry is that physical science which includes the study of a range of matters such as atoms, crystals, molecules and many other collections of matters whether they are in isolation or in combination. 2
  • 3. 3
  • 4.  Some of the higher study options after B.Sc Chemistry are -M.Sc. Chemistry -M.Sc.Analytical Chemistry -M.Sc. Drug Chemistry -M.Sc. Organic Pharmaceutical Chemistry -M.Sc. Physical &Materials Chemistry - M.Sc. By Research -Master of BusinessAdministration (MBA) - Ph.D in Chemistry Scope for Higher Studies after B.Sc Chemistry 4
  • 5.  Analytical Chemist  Biomedical Chemist  Production Officer Quality Controller  Associate Industrial Research Scientist  Lab Chemist  Materials Technologist  Production Chemist  Chemical Engineering  R&D Director  Research & Development Manager  Safety Health And Environment Specialist  Teacher 5
  • 6. The employment areas for the B.Sc Chemistry graduates include pharmaceutical industries, chemical manufacturers, Forensic Science Department, plastic industries, agrochemical industries, etc. Apart from these, they are also recruited in other fields such as oil, gas and power sectors and even in defence services. 6
  • 7. TOPPh.D. Institutes in India.  National Chemical Laboratory , Pune  IISER, Pune  IISER, Bhopal  National Institute of Chemical Technology, Hyderabad.  Indian Institute of Science , Bangalore  IIT , Bombay  IIT , Chennai  IIT, Kanpur  Institute of Chemical Technology , Mumbai.  Research Institutes affiliated to University. 7
  • 8. Government Jobs in Chemistry • UPSC www.upsconline .nic.in • MPSC www.mpsconline .gov.in • Forensic recruitment , Lecturer for gov Colleges for NET & Non NET candidates. • ONGC www.ongcindia.com form are continuethrough our the year. • NTPC www. Ntpccareers.net Various post in NTPC. • Geoscientist post for Chemistry and Lecturer post. 8
  • 9. SCOPE, Other Than Traditional :- • Scientist, Science communicator • Substantiality Manager. • Fragrance Chemist. • Favourist & innovation Director • Application Chemist • Organic Skincare & Cosmetic Range • Substantiality Consultant • Environmental Chemist.  9
  • 10. Indian ChemicalIndustry 1 Indian Chemical Industry plays a major role in the overall development of India Contributes significantly to India’s economy under manufacturing sector It accounts for approximately 7% of India’sGDP. Output value in the year 2012-13 was 782,949crores Indian chemical Industry is 6thin the world and 3rdinAsia India’s exports of chemicals (excluding pharma) was 32.02 US$billion in 2013, and imports US$46.01 Chemical industry growth rate of over 8-11% p.a.and expected to reach $290billion by 2017
  • 11. Chemicalindustries- Category 1 The chemical industries broadly categorised; Basic inorganic & Organic chemicals Specialty chemicals & fine chemicals Petrochemicals & plastics, Pesticides & Agrochemicals, Fertilizers Dyes & pigments Paints & varnishes, Soaps, perfumes & toiletries and Pharmaceuticals and others
  • 12. IndianPharmaceutical industry- overview. 1 Indian pharmaceutical industry is growing fast as like IT industry. Manufactures Quality Medicines at affordable cost. Significant growth is from 1990’s Market size is about 2 lakhscrore It is 3rdlargest in the world by volume (10%) and13th largest (~ 3%) inthe world in term of value. Growing at around 15-20% (6-8% in global). Expected grow and reach US$100 billion by2025.
  • 13. Indian Pharmaceutical industry 1 More than 90% of drugs used in India are produced in India The industry is quite fragmented and comprises of nearly 10,500 companies and majority of them in the small sector. Around 300-400 are organized companies categorized as medium & large Direct employment is 5lacs and total employment could be over 20lacs Mostly located in Maharashtra, Gujarat, Telungana , AP, HP, Tamil nadu.
  • 14. * AmongfastestgrowingIndustries:The IPI(Indian Pharmaceutical Industry) revenue is expected to expand at a CAGRof 17.8 % during 2008-16 andreach USD36 billion * Rapidgrowinghealthcare sector:By 2015, the healthcare sector is expected to reach USD100 billion from the current USD65billion. * GrowingGenericMarket:The generic market is expected to grow to USD26.1 Billion by 2016 from current USD11.3 billion in 2011; India genericsMarket has immense potential for growth th 7
  • 15. Export Indian PharmaIndustry 15 India competing with developed countries due to lower manufacturing cost with better Quality. India import was huge and higher than the export until late 1980s, Since 1990 export starts growing ,now export is 5 times higher thanimport. Export is 50% of the total turnover. Exported to >200 countries for both developed and developing countries. Around 25% of export is toUSA. 20% of the total volume of global generics ie 1 in 5of Generic * is from India. *Genericmedicines, andto low-cost versions of newly-developed medicines
  • 16. Highlightsof Indian Pharma Industry 02/25/16 16 In 2001, CIPLAwas in limelight, offered an AIDSdrug to for the price of $300 against $12,000 inUS. India manufactures 30% of the world requirement ofAnti- HIVdrugs key contributor to the WHOPrequalification Programme (PQP) 65-70% AIDS,Tuberculosis, Malaria, Reproductive Health, and etc... 2012, NATCOgot approval to sell kidney-cancer drug Nexavar at 3% of market price under compulsorylicense. CostRs.8500against Rs.2.8 lakh
  • 17. Advantageof Indian Pharma Industries 02/25/16 17 Global consumption of :The USaccounts for 40-45%, EUis about 20- 24% and Japan15%; balance is rest of world So target market is US,EU& BRICS. India is the highest USDMFapproved country outside theUS India accounts for 30.3 per cent (2,911) of 9619 Drug Master Files (DMFs) filed with USA,which is the highest outside of USA. 584 manufacturing sites approved by USFDAand next is Italy (<200) Several Indian Pharmaceutical companies set up plants in abroad Fast growth in R&Dactivities.
  • 18. SS The effects in new product patent SS Price control in the drugs SS Reformation in the regulatory SS Developments in the infrastructure SS Quality Management concept SS Conforming the global standards The other challenges include: * Decline in the production * Reducer in Drug Approvals * Stringent regulations 02/25/16 11
  • 19. GrowthPotential: Opportunity 19 Indian Pharma industry posses several strengths; Innovation and process design- to copy cat generic. Strong R&Dcapability, Qualified personnel Abundant skilled man power Around 270 large R& Dbased pharma companies in India. Past track is capable of producing better quality drugs with lower manufacturing cost. Knowledgeable and Skilled man power (Research, analytical, regulatory, clinical and IT)
  • 20. Research& Development: 20 Indian Pharma companies spent huge amount for R&D. Dr.Reddy’s, SunPharma, Gleanmark are investing in discovery research Several companies involved in process development and contract research. US$300bn worth of Patent drugs expiries by 2017. Global R&Dcost is estimated as USD65bn Contract Research
  • 21. TopIndian Pharmaceutical companies 1. Sun Pharma 2. Dr. Reddy's Labs 3. Cipla 4. GSK 5. Strides 6. Lupin 7. Aurabindo 8. Wockhardt 9. Zydas Cadila 10. NATCO 11. Orchid 12. IPCA 13. Biocon 14. Torrent 15. Shasun 16. Alambic etc 14 02/25/16
  • 22. WorldT opPharma Companies 22 Company Sales R&DExpense 1. Novartis $57,996 ($9946) 2. Pfizer $45,708 $8,393 3. Sanofi $41,047 $5,863 4. Roche $37,082 $9,006 5. Merck $36,042 $7,180 6. Johnson & Johnson $32,313 $6,213 7. GlaxoSmithKline $30,806 $5,693 8. AstraZeneca $26,095 $5,579 9. Gilead Sciences $24,890 $2,854 10. Teva $20,272 $1,488 Basedon 2014 Sales, in $U.S.Millions Ref:Contract pharma
  • 24. 8 – 12 years Drug Discovery is becoming more time and cost consuming… Drug discovery process : 02/25/16 24
  • 25. Clinicalstudy: 02/25/16 25 Aclinical trial is a tool for testing a drug, medical device, or technique for safety and efficacy. Global clinical trial market is ~USD 60bn. Money involved for new drug min is USD 600-mn 2bn out of this 150-200mn spent for clinical trials India will make it with 50-60% of cost and faster. The advantages are, technical resources (physician, nurses, and other technical personals), having developed IT infrastructure, protection on IPRrelated issues and etc.
  • 26. JobOpportunities 26 Pharma is knowledge based industry Special skills are required to work Offers excellent salary ,benefits & scope for growth. Jobopportunities for Chemistry / pharmacy graduates / pharmaceutical Technology/ Doctors Government & private sector
  • 27. JobOpportunities  Government& Public sector:  State & Central Govt  Public sector  National Labs  Drug testing  Research & Development  NIPER,CSIR, CDRL 27
  • 28. JobOpportunities in PharmaIndustry 02/25/16 28 Functions/Aactivities : Marketing & Sales –Technical Manufacturing/production Environment management Research & Development Quality control & Quality assurance Regulatory Affairs & IPR Clinical trials Testing laboratories- private
  • 29. Manufacturing/production: 29 Knowledge & Skill required: Process Chemistry Technology transfer Chemical reaction Handling of Chemicals Unit operations Reaction, distillation, filtration, drying, blending Formulation, etc
  • 30. Research& Development 30 Knowledge & Skill required: Synthesis- all kind of organic reaction Process chemistry Thermo chemistry Kinetics Structure elucidation Patent search New analytical techniques Simple & easy test methods
  • 31. QualityAssurance& Regulatory 02/25/16 31 Quality Assurance & Regulatory functions Pharma industries governed by stringent Rules& regulations Drugs & Cosmetic Act Quality system Good Manufacturing Practice (GMP) Documents for each activities Rules & Regulations as per exporting countries Regulatory Inspection and approvals
  • 32. Testing/Quality Control 25 Knowledge & Skill required for QCfunctions
  • 33. Analytical technique Chromatography Spectrophotometry Chiral testing- Optical rotation Particle size Dissolution Inorganic impurity -Residue on ignition Crystal structure- XRD Thermal properties - TGA/ DSC- Melting point 02/25/16 26
  • 34. Simpleinstruments for testing 34 pH meter Conductivity meter Polarimeter Refractometer Titrator Particle size Dissolution apparatus Etc…
  • 35. Spectroscopy 35 Theory, instrumentation and application UV-Visible spectrophotometer FT-IR Spectrum Mass spectrophotometer NMR AAS/ ICP-AESor OES XRD
  • 36. Chromatography 36 Extensively used technique is Chromatography for testing of purity and impurity in complex molecule; TLC Gas Chromatography HPLC Gel permeation Ion chromatography
  • 37. T esting 37 Drugs are tested for : Purity Impurities Structure confirmation –IR,UV Specific rotation Loss on drying/ water Residue of Ignition(inorganic) Dissolution Drug release Stability
  • 38. RegulatoryAffairs 38 Technical writing Rules & regulation of various countries Basic chemistry Basics of Process & testing Computer knowledge & communication
  • 39. Preparedness 39 Over 15 years, employment potential couldrange between 8-9 million jobs. Education & training Instrumentation course Diploma in pharmaceutical course Personal development Interview skill
  • 40. Reference: 40 Annual report 2014-15 & Chemicals & petrochemicals statistics AT AGLANCE: 2014 govt of india, ministry of chemicals &fertilizers INDIANCHEMICALINDUSTRY:Five year plan –2012-2017 The pharmaceutical industry and Global health facts and Figures 2014: IFPMA India Pharma summit 2014-15 position paper; dept of pharmaceuticals, govt of india India Chem 2014 :Spurting the growth of Indian Chemical Industry: FICCI ABrief report of Indian pharmaceutical industry InIndia- ASA Associates India PharmaInc.Gearing up for the next level of growth PWC Fromvisionto decisionPharma 2020- PWC Profile of pharmaceutical industry- Chapter –iv Wikipedia