Ciplox Tablets (Generic Ciprofloxacin Hydrochloride Tablets)

Ciplox Tablets (Generic Ciprofloxacin Hydrochloride Tablets)
© The Swiss Pharmacy

Ciplox (Generic Ciprofloxacin Hydrochloride Tablets) is
a Fluoroquinolone antibacterial indicated in adults 18
years of age and above to treat infections caused by
designated, susceptible bacteria including mixed
infections caused two or more organisms as well as in
pediatric patients where indicated.
It may also use for infections caused by multidrug-
resistant bacteria.

Ciplox Tablets are manufactured by Cipla Limited,
India in the strengths of 250 mg and 500 mg.

Chemical Structure

The active ingredient
present in Ciplox tablets is
Ciprofloxacin Hydrochloride.
Each Ciplox Tablet contains
Ciprofloxacin Hydrochloride,
IP, equivalent to 250 mg or
500 mg of Ciprofloxacin, IP .

Uses of Ciplox 250 mg and 500 mg Tablets:
Ciplox tablets (Ciprofloxacin Hydrochloride tablets) is used to treat
bacterial infections in many different parts of the body. Ciprofloxacin
oral liquid and tablets are also used to treat anthrax infection after
inhalational exposure. This medicine is also used to treat and prevent
plague (including pneumonic and septicemic plague). Ciprofloxacin
may mask or delay the symptoms of syphilis. It is not effective against
syphilis infections.
Ciprofloxacin belongs to the class of drugs known as quinolone
antibiotics. It works by killing bacteria or preventing their growth.
However, this medicine will not work for colds, flu, or other virus
infections.
URL: https://www.theswisspharmacy.com/product_info.php?info=p9532_Ciprofloxacin-Tablets.html

Ciplox Tablets are indicated for the treatment of the following
infections caused by susceptible bacteria:
Respiratory Tract Infections:
Acute and chronic bronchitis, obstructive airways disease (COPD),
empyema, lung abscess, bronchiectasis, lobar and
bronchopneumonia, acute exacerbation of cystic fibrosis, otitis media,
sinusitis and mastoiditis especially due to gram-negative bacteria
(including Pseudomonas sp.)
Urinary Tract Infections:
Acute and chronic pyelonephritis, cystitis, urethritis, prostatitis,
epididymitis and chronic complicated or recurrent UTI caused by
multi-drug resistant organisms and/or Pseudomonas aeruginosa.

Skin And Soft Tissue Infections:
Generic Ciprofloxacin is used to treat surgical and post-operative
wound infections due to gram-negative organisms such as
Pseudomonas aeruginosa. It is also useful in infections caused by
resistant Staphylococci including infected ulcers, wound infections,
abscesses, cellulitis, erysipelas, infected burns.
Surgical Infections:
Ciplox is used to treat Peritonitis, intra-abdominal abscess,
cholangitis, cholecystitis, empyema of gall bladder.
Bone And Joint Infections:
Acute and chronic osteomyelitis, septic arthritis.

Pelvic Infections:
Salpingitis, endometritis, pelvic inflammatory disease.
Sexually Transmitted Diseases:
Gonorrhoea including that caused by beta-lactamase producing
strains and chancroid caused by H.ducreyi.
Gastrointestinal Infections:
Enteric fever, infective diarrhoea.
Severe Systemic Infections:
Septicaemia, bacteraemia, infections in immunocompromised
patients.

Recommended Adult Dosage
Ciplox tablets (Generic Ciprofloxacin Hydrochloride tablets) should
be swallowed whole with adequate amount of water or liquid.
Ciplox tablets can be taken with or without meals.
Respiratory tract, bone and joint infections:
Mild/moderate 500 mg twice daily/or 1000 mg once daily
Severe/complicated 750 mg twice daily
Urinary tract infections:
Acute uncomplicated 500 mg od for 3 days
Mild/moderate 250 mg twice daily / 500 mg once daily
Severe/complicated 500 mg twice daily/or 1000 mg once daily.

Infectious Diarrhoea:
Mild/moderate/severe 500 mg twice daily/or 1000 mg once
daily
Gonorrhoea: 250 mg single dose
Non-gonococcal urethritis: 750 mg twice daily
Chancroid: 500 mg twice daily/1000 mg once daily

Chronic Bacterial prostatitis:
1000 mg once daily for 28 days
Skin and Skin Structure:
500mg to 750 mg every 12 hours for 7 to 14 days
Lower Respiratory Tract Infections:
500mg to 750 mg every 12 hours for 7 to 14 days
Acute Sinusitis:
500 mg every 12 hours for 10 days

Contraindications
➔
Hypersensitivity to Ciprofloxacin Hydrochloride other
quinolones, or any inactive component of the preparation.
➔
Concomitant administration with Tizanidine is
contraindicated.

Storage Instructions
Ciplox Tablets (Generic Ciprofloxacin Hydrochloride
Tablets) have to be stored at controlled room
temperature i.e. from 20°C to 25°C (68°F to 77°F) with
excursions permitted between 15° to 30°C (59° to
86°F).
Keep this as well as all other medicines away from
children and pets.

Warnings
Hypersensitivity and other serious reactions: Serious and sometimes
fatal reactions (for example, anaphylactic reactions) may occur after
the
first or subsequent doses of Ciplox (Ciprofloxacin Hydrochloride
tablets). Discontinue Ciplox at the first sign of skin rash, jaundice or any
sign of hypersensitivity.
Hepatotoxicity: Discontinue immediately if signs and symptoms of
hepatitis occur.
Clostridium difficile-associated diarrhea: Evaluate if colitis occurs.
QT Prolongation: Prolongation of the QT interval and isolated cases of
torsade de pointes have been reported. Avoid use in patients with
known prolongation, those with hypokalemia, and with other drugs that
prolong the QT interval.

Warnings
Fluoroquinolones, including Ciplox, are associated with an increased
risk of tendinitis and tendon rupture in all ages.
The risk of tendon rupture is further increased in older patients usually
over 60 years of age, in patients taking corticosteroid drugs, and in
patients with kidney, heart or lung transplants.
Since Fluoroquinolones, including Ciplox tablets, have been associated
with serious adverse reactions, reserve Ciplox for use in patients who
have no alternative treatment options for uncomplicated urinary tract
infections.

Possible Side Effects
The most common Ciprofloxacin Hydrochloride (Ciplox
Tablets) side effects with an incidence rate of 1% or greater
were nausea, diarrhea, liver function tests abnormal, vomiting,
and rash.

Ciplox Overdosage
In the event of acute overdosage, reversible renal toxicity has been
reported in certain cases. The stomach should be emptied by inducing
vomiting or by gastric lavage.
The patient should be carefully monitored and given supportive
treatment, including monitoring of renal function and administration of
magnesium, aluminum, or calcium containing antacids which can
reduce the absorption of Ciprofloxacin.

Treatment of Ciplox Overdosage
The patient should be carefully monitored and given supportive
treatment, including monitoring of renal function and administration of
magnesium, aluminum, or calcium containing antacids which can
reduce the absorption of Ciprofloxacin.
Based on information obtained from subjects with chronic renal failure,
only a small amount of ciprofloxacin (less than 10%) is removed from
the body after hemodialysis or peritoneal dialysis.
The administration of activated charcoal as soon as possible after oral
overdose may prevent excessive increase of systemic ciprofloxacin
exposure.

Ciplox Tablets During Pregnancy
Ciprofloxacin Hydrochloride (Ciplox Tablets) is classified by the US
FDA as Pregnancy Category C. There are no adequate and well-
controlled studies in pregnant women.
Ciplox tablets should not be used during pregnancy unless the
potential benefit justifies the potential risk to both fetus and mother.
An expert review of published data on experiences with Ciprofloxacin
Hydrochloride use during pregnancy by TERIS–the Teratogen
Information System–concluded that therapeutic doses during
pregnancy are unlikely to pose a substantial teratogenic risk (quantity
and quality of data=fair), but the data are insufficient to state that there
is no risk.

Ciplox Tablets (Generic Ciprofloxacin
Hydrochloride Tablets) are manufactured by Cipla
Limited, India.

Ciplox Tablets (Generic Ciprofloxacin Hydrochloride Tablets)

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