Penegra Tablets (Generic Sildenafil Citrate Tablets)

Penegra Tablets (Generic Sildenafil Citrate Tablets)
© The Swiss Pharmacy

Penegra (Generic Sildenafil Citrate Tablets) is a
phosphodiesterase 5 (PDE5) inhibitor used to treat adult
men who have erectile dysfunction (also called sexual
impotence or erectile dysfunction, also known in short as
ED).
In combination with sexual stimulation, Sildenafil Citrate
works by increasing blood flow to the penis to help a man
get and keep an erection.
Penegra tablets are available in strengths of 50 mg and 100
mg.

Penegra tablets are manufactured by Zydus Healthcare Limited,
India in strengths of 50 mg and 100 mg.

Chemical Structure

The active ingredient contained in Penegra tablets is Sildenafil
Citrate.
Each film coated Penegra tablet contains Sildenafil Citrate equivalent
to 50 mg or 100 mg of Sildenafil.

Uses of Penegra 50 mg and 100 mg Tablets:
Penegra (Generic Sildenafil Citrate Tablets) is an oral treatment for
adult men suffering from erectile dysfunction. Erectile dysfunction is a
condition where the penis does not harden and expand when a man
is sexually excited, or when he cannot keep an erection.
When a man is sexually stimulated, his body's normal response is to
increase blood flow to his penis to produce an erection. By controlling
the enzyme, Sildenafil Citrate helps to maintain an erection after the
penis is stroked.
Without physical action to the penis, such as that occurring during
sexual intercourse, Penegra will not work to cause an erection.
URL: https://www.theswisspharmacy.com/product_info.php?info=p9672_Penegra-Tablets.html

Uses of Penegra 50 mg and 100 mg Tablets:
Sildenafil restores impaired erectile function by increasing blood flow
to the penis, resulting in a natural response to sexual stimulation.
Penegra Tablets (Sildenafil Citrate) for erectile dysfunction can be
taken by men aged 18 and over. It's not indicated for women or
children.
Sildenafil is also used in both men and women to treat the symptoms
of pulmonary arterial hypertension. This is a type of high blood
pressure that occurs between the heart and the lungs. When
hypertension occurs in the lungs, the heart must work harder to pump
enough blood through the lungs. Sildenafil works on the PDE5 enzyme
in the lungs to relax the blood vessels. This will increase the supply of
blood to the lungs and reduce the workload of the heart.

Recommended Adult Dosage
For most patients, the recommended dose of Penegra Tablets
(Generic SildenafilCitrate Tablets) is 50 mg taken, as needed,
approximately 1 hour before sexual activity. However, Penegra
(Generic Sildenafil Citrate tablets) may be taken anywhere from 30
minutes to 4 hours before sexual activity.
Based on effectiveness and toleration, the dosage may be increased
to a maximum of 100 mg or decreased to 25 mg.
Maximum recommended dosing frequency is once per day (i.e. 24
hours must pass before you take the next dose)

Contraindications
➔
Penegra is contraindicated in patients with a known hypersensitivity to
Sildenafil Citrate or any component of the tablet.
➔
Administration of Penegra to patients using nitric oxide donors, such as
organic nitrates or organic nitrites in any form. Penegra was shown to
potentiate the hypotensive effect of nitrates.
➔
Administration of Penegra with Guanylate Cyclase (GC) stimulators, such
as Riociguat is contraindicated.
➔
Penegra (Sildenafil), should not be used in men for whom sexual activity
is inadvisable (e.g. patients with severe cardiovascular disorders such as
unstable angina or severe cardiac failure).

Storage Instructions
Penegra Tablets (Generic Sildenafil Citrate Tablets) have to be stored
at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F)
with excursions permitted between 15° to 30°C (59° to 86°F).
Keep this as well as all other medicines away from children and pets.

Warnings
Patients should not use Penegra if sexual activity is inadvisable due to
cardiovascular status.
Patients should seek emergency treatment if an erection lasts for
greater than 4 hours. Use Penegra with caution in patients predisposed
to priapism.
Patients should stop Penegra and seek medical care if a sudden loss of
vision occurs in one or both eyes, which could be a sign of non arteritic
anterior ischemic optic neuropathy (NAION). Penegra should be used
with caution, and only when the anticipated benefits outweigh the
risks, in patients with a history of NAION. Patients with a "crowded"
optic disc may also be at an increased risk of NAION.

Warnings
Patients should stop Penegra and seek prompt medical attention in the
event of sudden decrease or loss of hearing.
Caution is advised when Penegra is co-administered with alpha-
blockers or anti-hypertensives. Concomitant use may lead to
hypotension.
Decreased blood pressure, syncope, and prolonged erection may
occur at higher Sildenafil exposures. In patients taking strong CYP
inhibitors, such as Ritonavir, Sildenafil exposure is increased. Decrease
in Penegra dosage is recommended.

Effects On Ability To Drive And Use Machines
No studies on the effects on the ability to drive and use machines
have been performed.
As dizziness and altered vision were reported in clinical trials with
Sildenafil Citrate, patients should be aware of how they react to
Penegra tablets (Sildenafil Citrate), before driving or operating
machinery.

Possible Side Effects
Most common Penegra (Generic Sildenafil Citrate tablets)
side effects with an incidence rate of greater than or
equal to 2% include headache, flushing, dyspepsia,
abnormal vision, nasal congestion, back pain, myalgia,
nausea, dizziness and rash.

The following side effects occurred in less than 2% of of patients in controlled clinical
trials; a causal relationship to Sildenafil Citrate (Penegra Tablets) is uncertain.
Body as a Whole: face edema, photosensitivity reaction, shock, asthenia, pain, chills,
accidental fall, abdominal pain, allergic reaction, chest pain, accidental injury.
Cardiovascular: angina pectoris, AV block, migraine, syncope, tachycardia, palpitation,
hypotension, postural hypotension, myocardial ischemia, cerebral thrombosis, cardiac
arrest, heart failure, abnormal electrocardiogram, cardiomyopathy.
Digestive: vomiting, glossitis, colitis, dysphagia, gastritis, gastroenteritis, esophagitis,
stomatitis, dry mouth, liver function tests abnormal, rectal hemorrhage, gingivitis.
Hemic and Lymphatic: anemia and leukopenia.
Metabolic and Nutritional: thirst, edema, gout, unstable diabetes, hyperglycemia,
peripheral edema, hyperuricemia, hypoglycemic reaction, hypernatremia.
Musculoskeletal: arthritis, arthrosis, myalgia, tendon rupture, tenosynovitis, bone pain,
myasthenia, synovitis.

The following side effects occurred in less than 2% of of patients in controlled clinical
trials; a causal relationship to Sildenafil Citrate (Penegra Tablets) is uncertain.
Nervous: ataxia, hypertonia, neuralgia, neuropathy, paresthesia, tremor, vertigo,
depression, insomnia, somnolence, abnormal dreams, reflexes decreased,
hypesthesia.
Respiratory: asthma, dyspnea, laryngitis, pharyngitis, sinusitis, bronchitis, sputum
increased, cough increased.
Skin and Appendages: urticaria, herpes simplex, pruritus, sweating, skin ulcer, contact
dermatitis, exfoliative dermatitis.
Special Senses: sudden decrease or loss of hearing, mydriasis, conjunctivitis,
photophobia, tinnitus, eye pain, ear pain, eye hemorrhage, cataract, dry eyes.
Urogenital: cystitis, nocturia, urinary frequency, breast enlargement, urinary
incontinence, abnormal ejaculation, genital edema and anorgasmia.

Penegra Tablets Overdosage
Overdose information of Sildenafil Citrate (Penegra Tablets) is limited.
In studies with healthy volunteers, of single doses up to 800mg,
adverse effects were similar to those seen at lower doses but
incidence rates and severities were increased. Survival is reported in
a 42-year-old female following an overdose with 2,000mg Sildenafil.
In cases of overdose, standard supportive measures should be
adopted as required. Sildenafil blood levels are not clinically
useful.
Monitor ECG and blood pressure in symptomatic patients. Renal
dialysis is not expected to accelerate clearance as Sildenafil is highly
bound to plasma protein and not eliminated in the urine.

Penegra Tablets During Pregnancy
Sildenafil Citrate (Penegra Tablets) has been classified by the US FDA
as Pregnancy Category B.
Sildenafil Citrate is not indicated for use in females. There are no data
with the use of Sildenafil in pregnant women to inform any drug-
associated risks for adverse developmental outcomes.
Animal reproduction studies conducted with Sildenafil Citrate did not
show adverse developmental outcomes when administered during
organogenesis in rats and rabbits at oral doses up to 16 and 32 times,
respectively, the maximum recommended human dose (MRHD) of
100mg/day on a mg/m basis.

are manufactured by Zydus Healthcare Limited, India.

Penegra Tablets (Generic Sildenafil Citrate Tablets)

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