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111 سؤال وجواب حول الوقاية ضد سرطان عنق الرحم
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In recent years, the growth of scientific data and the increasing need for data sharing and collaboration in the field of environmental chemistry has led to the creation of various software and databases that facilitate research and development into the safety and toxicity of chemicals. The US-EPA Center for Computational Toxicology and Exposure has been developing software and databases that serve the chemistry community for many years. This presentation will focus on several web-based software applications which have been developed at the USEPA and made available to the community. While the primary software application from the Center is the CompTox Chemicals Dashboard almost a dozen proof-of-concept applications have been built serving various capabilities. The publicly accessible Cheminformatics Modules (https://www.epa.gov/chemicalresearch/cheminformatics) provides access to six individual modules to allow for hazard comparison for sets of chemicals, structure-substructure-similarity searching, structure alerts and batch QSAR prediction of both physicochemical and toxicity endpoints. A number of other applications in development include a chemical transformations database (ChET) and a database of analytical methods and open mass spectral data (AMOS). Each of these depends on the underlying DSSTox chemicals database, a rich source of chemistry data for over 1.2 million chemical substances. I will provide an overview of all tools in development and the integrated nature of the applications based on the underlying chemistry data. This abstract does not necessarily represent the views or policies of the U.S. Environmental Protection Agency.
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In-Pond Raceway Systems (IPRS) represent a cutting-edge method in pond aquaculture, effectively combining the advantages of confining fish in a restricted area within the pond with the efficiency of a flowing water system. This innovative approach facilitates water circulation within the pond, mimicking the natural flow found in riverine environments. By creating this dynamic water movement, IPRS significantly enhances the pond's productivity potential. The core principle of IPRS involves the installation of specific components that work in concert to circulate and refresh the water within the pond, all while preventing any discharge into the surrounding environment. This setup effectively utilizes a dividing partition, or baffle, to create a circular water flow pattern. As a result, the water undergoes continuous mixing and movement, optimizing conditions for fish growth and minimizing stagnation.
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Mars is a particularly attractive candidate among known astronomical objects to potentially host life. Results from space exploration missions have provided insights into Martian geochemistry that indicate oxychlorine species, particularly perchlorate, are ubiquitous features of the Martian geochemical landscape. Perchlorate presents potential obstacles for known forms of life due to its toxicity. However, it can also provide potential benefits, such as producing brines by deliquescence, like those thought to exist on present-day Mars. Here we show perchlorate brines support folding and catalysis of functional RNAs, while inactivating representative protein enzymes. Additionally, we show perchlorate and other oxychlorine species enable ribozyme functions, including homeostasis-like regulatory behavior and ribozyme-catalyzed chlorination of organic molecules. We suggest nucleic acids are uniquely wellsuited to hypersaline Martian environments. Furthermore, Martian near- or subsurface oxychlorine brines, and brines found in potential lifeforms, could provide a unique niche for biomolecular evolution.
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Emergent ribozyme behaviors in oxychlorine brines indicate a unique niche for...
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