Mycobacterial infections and its pathogeenesis, includes M. kansasii infections, it can be categorized into six clinical patterns: pulmonary disease, skin and soft tissues, musculoskeletal infections, disseminated disease, catheter-allied disease, and lymphadenitis. Chronic pulmonary cavitary disease in the upper lobe is the most common presentation of M. kansasii infectionsPATHOGENICITY The common symptoms of pulmonary M. kansasii infection include a cough (92%), sputum production (86%), weight loss (54%), breathlessness (52%), chest pain (35%), hemoptysis (33%), and fever or sweats (18%). Of all the NTM infections, M. kansasii infections most often resemble Mycobacterial tuberculosis infections (Lillo et al.,1990). Risk factors and pathogenicity for M. kansasii infections are the same as those for other mycobacteria, mainly

1. PATHOGENSIS of Myocabacterium.
kansasii
BY SREEREMYA
FACULTY OF BIOLOGY

2. • Mycobacterial infections and its pathogeenesis,
includes M. kansasii infections, it can be
categorized into six clinical patterns: pulmonary
disease, skin and soft tissues, musculoskeletal
infections, disseminated disease, catheter-allied
disease, and lymphadenitis. Chronic pulmonary
cavitary disease in the upper lobe is the most
common presentation of M. kansasii infections

3. • PATHOGENICITY
• The common symptoms of pulmonary M. kansasii
infection include a cough (92%), sputum
production (86%), weight loss (54%),
breathlessness (52%), chest pain (35%),
hemoptysis (33%), and fever or sweats (18%). Of
all the NTM infections, M. kansasii infections
most often resemble Mycobacterial tuberculosis
infections (Lillo et al.,1990). Risk factors and
pathogenicity for M. kansasii infections are the
same as those for other mycobacteria, mainly

4. • The second most organ easily prone to M.
kansasii infection is the skin. Cutaneous
infection resembles secondary to local
lymphatic spread(Ohnishi et al.,2011).).

5. • Cutaneous lesions may encompasses nodules,
pustules, verrucous lesions, erythematous
plaques, abscesses, and ulcers. In HIV and
immunocompromised patients, the
presentation can be atypical and may include
bacteremia, osteomyelitis, abscesses, and
cellulitis. Pericarditis with cardiac tamponade
has been reported in HIV patients(Blanc et
al.,2016

6. • Characteristics
• Mycobacterium kansasii is an acid-fast bacillus
that has profoundly emerged as a significant
pathogen of the group of nontuberculous
mycobacteria (NTM). It is the second most-
common nontuberculous opportunistic
mycobacterial infection associated with AIDS,
which is surpassed only by Mycobacterium avium
complex (MAC) . In addition, M. kansasii infects
both immuno competent and immuno
compromised patients . The

7. • M. kansasii mainly causes pulmonary infection
that quietly resembles tuberculosis clinically
and radiographically and is indistinguishable
from Mycobacterium tuberculosis infection
(Bloch et al.,1998).

8. • Comorbidity diseases are frequently related and
connected with M. kansasii pulmonary infection,
icomprising chronic obstructive pulmonary
disease, bronchiectasis, pneumonoconiosis,
previous tuberculosis, or carcinoma . In addition,
extrapulmonary infection of M. kansasii can cause
gastroenteritis, lymphadenitis, osteomyelitis,
synovitis, cellulitis, empyema or pericarditis . In
addition, disseminated M. kansasii infections also
commonly occur, especially in immuno
compromised patients with advanced AIDS .

9. • In comparison with the widely researched M.
tuberculosis, most reports on M. kansasii
focus on epidemiological and clinical features
of infection . Very Little is known about the
innate immune response against M. kansasii
infection(

10. • EPIDEMIOLOGY
• Lung infections are mainly caused by M. kansasii occur in
geographic clusters(Haddad et al.,2005). In the United
States, M. kansasii infections are generally common in
southern and central states with the incidence seen in the
southern states of Texas Louisiana and Florida, as well as
the central states of Illinois, Kansas, and Nebraska. M.
kansasii infections are more prone to occur in urban areas
than rural areas. In the United Kingdom, M. kansasii
infections are most frequently reported in Wales(Griffith et
al.,2007). Of all the countries in Europe, Poland has the
highest M. kansasii isolation rate (36% of all NTM compared
to 6% in Europe)

11. REFERNCE
•
• Journal of Biomedical and Instrumentation
Engineering, pathogensis of Myocabacterium.
Kansasii,S.Sreeremya.2018.Vol(4):1,1-9.