mucormycosis important points

1. Mucormycosis

2. Background

3. Acute Invasive Fungal Sinusitis
 Life threatening ,sight threatening infection of
nose and paranasal sinuses.
 Most lethal form of fungal sinusitis-mortality 50%
to 80%.
 Fungi such as Aspergillus and the Mucorales
order, especially Rhizopus and Mucor, are
particularly important pathogens.
 Mucormycosis-ubiquitous in soil and form
sporangiospores
 Mode of infection-inhalation of spores

4. Risk Factors

5. Pathogenesis
 Angioinvasion
 Vessel thrombosis
 Tissue necrosis

6. COVID associated Mucormycosis

7. CLINICAL FEATURES

8. Symptoms
 Fever
 Rhinorrhea(bloody/brownish),nasal obstruction
 Headache
 Vision loss
 Facial hyposthesia,swelling,pain
 Pain and redness around the eyes,proptosis
 Ophthalmoplegia
 Loosening of teeth

9. Signs

11. Investigations

12. KOH Mount-Broad aseptate hyphae
with wider branching.

13. Histopathology

14. Imaging

15. CT PNS-soft tissue density with bone
erosion

16. MRI-TI hypointense T2
heterogenous,iso or hyperintense

17. MRI T1 post contrast heterogenous
enhancement

18. Staging

19. Treatment

23. Other Investigations

24.  Calcoflour white staining
 Culture of fungus and antifungal susceptibility
 MALDI-TOF(Matrix Assisted Laser Desorption
Ionisation-Time of Flight Mass Spectroscopy)
 Biomarkers-Beta-D-Glucan,Galactomannan (if
negative Mucor likely)
 Mucor Polymerase Chain Reaction