It behaves as a competetive inhibitor of histamine release in-vivo and in-vitro, hence posseses antihistaminic and antiallergic properties.

1. Nimesulide drug interactions
Nimesulide is analgesic, antipyretic and anti-inflammatory agent that differs from
conventional nonsteroidal anti-inflammatory drugs both in structure and pharmacological
profile.
It inhibits prostaglandin synthetase/cyclooxygenase, which limits prostaglandin production.
Its cyclooxygenase inhibiting potency is intermediate, but is relatively selective for the
cyclo-oxygenase-2 (COX-2) thus the potential for gastric injury and intolerance is less. It is
also a free radical scavenger, and helps protect against the tissue damage that occurs
during inflammation.
Since nimesulide may be prescribed for patients receiving concomitant medication, the
propensity for drug interactions exists.
Major interactions involving interference with drug metabolism have not been described
with Nimesulide.
Its main purpose is to treat acute pain, the symptomatic treatment of osteoarthritis and
primary dysmenorrhoea .
Nimesulide Tablet shows the result from pain within 15min from the drug intake
Nimesulide is available in the from of tablet, capsule and gel with the dosage of 100mg
Nimesulide is preffered for the shortest duration to minimize the risk of hepatotoxicity.