Nimesulide is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, Nimesulide should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. Nimesulide has a solubility of approximately <200 μg/ml in a 10% DMSO in PBS (pH 7.2) solution using this method. NSAID drug NImesulide has proven benefits in the treatment of Acute (short term) pain, Painful osteoarthritis (Swelling in the joints) and Primary dysmennorhea (Period Pains). Nimesulide is available in various forms like Nimesulide Tablets, Nimesulide Powder, Nimesulide Gell, suppositories etc. Nimesulide is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).

1. Nimesulide Solubility
Nimesulide is a unique non- steroidal anti-inflammatory drug that acts specifically on
cyclo-oxygenase-2 and does not affect cyclo-oxygenase-1. Hence, it exerts its anti-
inflammatory action characteristics of non- steroidal anti-inflammatory drug. Solubility
of Nimesulide Increased on solubilization of drug in semi-polar solvents and non-
ionic surfactants.
Solubility of Nimesulide was studied using different cosolvent mixtures and various
classes of non-ionic surfactant. Solubility increased drastically (>70 mg/rnl) when
polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.
The quick dissolving tablets of Nimesulide contains superdisintegrants, that
accelerates the disintegration of tablets by virtue of their ability to soak up great
deal of water once exposed to binary compound surroundings.
Nimesulide is sparingly soluble in aqueous buffers. For maximum solubility in
aqueous buffers, Nimesulide should first be dissolved in ethanol and then diluted
with the aqueous buffer of choice. Nimesulide has a solubility of approximately
<200 ΜG/ML IN A 10% DMSO IN PBS (PH 7.2) SOLUTION USING THIS METHOD.
NSAID drug NImesulide has proven benefits in the treatment of Acute (short term)
pain, Painful osteoarthritis (Swelling in the joints) and Primary dysmennorhea (Period
Pains).
Nimesulide is available in various forms like Nimesulide Tablets, Nimesulide Powder,
Nimesulide Gell, suppositories etc.
Nimesulide is soluble in organic solvents such as ethanol, DMSO, and dimethyl
formamide (DMF).
nimesulide is an effective and safe therapeutic choice for the treatment of various
painful inflammatory conditions, with a rapid onset of analgesic activity.As for other
NSAIDs the use of nimesulide is recommended for the shortest duration necessary
to control symptoms in patients with acute pain or primary dysmenorrhoea.