It has superior gastrointestinal safety as compared to other NSAIDs. It is an analgesic and antipyretic in action, other than its anti inflammatory action.

1. Nimesulide mechanism of action
Nimesulide is a prescription non-steroidal anti-inflammatory drug with a multifactorial mode
of action, characterized by a fast onset of analgesic activity.
It must be used under supervision by a doctor in accordance with the approved indications
and in compliance with the recommendations included in the Summary of Product
Characteristics.
In 1980 the original nimesulide molecule was in-licensed by Helsinn Healthcare, a
pharmaceutical company based in Switzerland. In 1985 it was first launched in Italy by
Helsinn’s local licensees under the brand names Aulin and Mesulid.
Helsinn manufactures the original Nimesulide active ingredient and finished products in full
compliance with the current Good Manufacturing Practice (cGMP) guidelines in its plants
in Switzerland and Ireland.
Nimesulide drug was launched in Italy for the first time as Aulin and Mesulid in 1985 and is
presently available in more than 50 countries worldwide with different trademarks.
Nimesuilde is a pain killer NSAIDs drug is the best prescribed drug for treatment of acute
pain, Primary dysmennorhea and also to treat degenerative joint disease
Its multifactorial mode of action gives it a unique and broad action on inflammatory
processes.