Nimesulide is a non-steroidal anti-inflammatory drug that specifically targets cyclooxygenase-2. Its solubility increases significantly when dissolved in semi-polar solvents, non-ionic surfactants, or mixtures of polyethylene glycol 300 and 400. Quick dissolving tablets of Nimesulide contain superdisintegrants that help the tablets break down rapidly in aqueous environments to improve solubility. Nimesulide has low solubility in aqueous buffers but dissolving it first in ethanol before diluting with buffer increases its solubility to around 200 micrograms per milliliter in a 10% DMSO-PBS solution.

1. Nimesulide solubility
Nimesulide is a unique non- steroidal anti-inflammatory drug that acts specifically on cyclo-
oxygenase-2 and does not affect cyclo-oxygenase-1. Hence, it exerts its anti-inflammatory
action characteristics of non- steroidal anti-inflammatory drug. Solubility of Nimesulide
Increased on solubilization of drug in semi-polar solvents and non-ionic surfactants.
Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of
non-ionic surfactant. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol
300 and polyethylene glycol 400 were used as solvents.
The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the
disintegration of tablets by virtue of their ability to soak up great deal of water once exposed
to binary compound surroundings.
Nimesulide is sparingly soluble in aqueous buffers. For maximum solubility in aqueous
buffers, Nimesulide should first be dissolved in ethanol and then diluted with the aqueous
buffer of choice. Nimesulide has a solubility of approximately <200 g/ml in a 10% DMSO inμ
PBS (pH 7.2) solution using this method.