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ZIKA VIRUS
PRESENTED
BY
IWUAGWU
CHUKWUNYERE
OUTLINE:
• Definition.
• Brief history
• Countries affected
• Mode of transmission
• Symptoms
• Population at risk
• Complications
• Diagnosis
• Treatments
• Prevention
• References
DEFINITION:
• Zika is a viral disease caused by an arbovirus of the
flavivirus family.
• Is a mosquito-borne single-stranded RNA virus related to
dengue virus
• The disease is characterize by:
– acute febrile illness similar to dengue fever,
– rash,
– inflammation of the joints
– conjunctivitis.
BRIEF HISTORY:
• Zika virus was first isolated from a rhesus monkey in
Uganda’s Zika Forest in 1947.
• The virus is common in:
– West and Central Africa
– but also occurs in Pakistan, India, Vietnam,
– Thailand, the Philippines, Malaysia, Indonesia
– and Micronesia.
BRIEF HISTORY:
• It was isolated for the first time from humans in Nigeria in
1968.
• In recent years the virus has spread throughout the Pacific,
with outbreaks in:
– the Cook Islands
– New Caledonia
– French Polynesia
– Easter Island.
BRIEF HISTORY
• Only a few imported cases have been reported in Australia, with
no locally acquired infections.
Countries/territories with reported cases of
Zika virus infection in the past nine months
and past two months, as of 19 January 2016
• Barbados
• Bolivia
• Brazil
• Cape Verde
• Colombia
• Ecuador
• El Salvador
• Fiji*
• Puerto Rico
• Saint Martin
• Samoa
• Solomon Islands*
• Suriname
• French Guiana
• Guadeloupe
• Guatemala
• Guyana
• Haiti
• Honduras
• Maldives*
• Martinique
• Mexico
• New Caledonia*
• Panama
• Paraguay
• Thailand
• Venezuela
MODES OF TRANSMISSION :
• Zika is a disease of monkeys and humans transmitted by
mosquitoes:
– Aedes africanus isthe vector in forest areas in Africa, while
– Aedes aegypti, the dengue mosquito, is the probable vector in
other areas.
• Aedes albopictus mosquitoes can also transmit the virus.
• Aedes mosquitoes are aggressive daytime biters and feed
both indoors and outdoors.
MODES OF TRANSMISSION
• Zika virus can be transmitted locally from:
• A pregnant mother to her fetus during pregnancy or around the
time of birth.
• Person -to-person through blood or sexual contact
SYMPTOMS:
• Clinical symptoms last for 4-7 days and include:
– headache
– muscle aches
– Maculopapular rash
– fever
– Conjunctivitis
– joint pain mainly joints of the hands and feet)
– diarrhoea.
POPULATION AT RISK:
• Anyone who is living in or traveling to an area where Zika
virus is found.
• Anyone who has not been previously exposed to the virus.
COMPLICATIONS:
• Guillain-Barré syndrome:
– An increase cases has been documented in areas where the virus is
endemic.
– direct causal relationship has not been established
• Microcephaly:
– Avialable data suggests a positive correlation between newborn babies
of infected mothers and microcephaly
• Intracranial Calcification.
DIAGNOSIS
• Zika virus RNA detected by RT-PCR in any clinical specimen
within the first 3-5 days after the onset of symptoms,
• Serological test to detect Zika virus IgM with confirmatory
neutralizing antibody titers that are ≥4-fold higher than dengue
virus neutralizing antibody titers in serum.
• Testing would be considered inconclusive if Zika virus
neutralizing antibody titers are < 4-fold higher than dengue
virus neutralizing antibody titers.
• Serological tests are useful only after five days
• There is no specific treatment for the infection but it can
be managed symptomatically.
• Currently there is no vaccination for the virus.
• However, work has already begun in developing one but
might take about 10-12 years .
TREATMENT
PREVENTION
• Eliminate potential breeding sites of mosquitoes
• Personal protection equipments such as:
– Wearing loose, light-coloured protective clothing in outdoor situations,
covering feet, legs and arms.
– Avoid scents on the body, such as perfume, deodorants and sweat, since
these can attract mosquitoes.
• Sleep under insecticide treated bed nets.
• Although there is no travel restriction imposed
on the affected regions by WHO; pregnant
women are advised not travel to Zika virus
endemic regions within their first trimester.
REFERENCES
• The public health Emergency Operations Center report on microcephaly.
Epidemiological Week 46 of 2015. Brazil Ministry of Health. Available at:
http://portalsaude.saude.gov.br/index.php/cidadao/principal/agencia-saude/20925-
ministerio-divulga-boletim-epidemiologico
• 2. Epidemiological Bulletin. Colombia National Institute of Health.
Epidemiological Week 46 of 2015. Available at: http://www.ins.gov.co/boletin-
epidemiologico/Boletn%20Epidemiolgico/2015%20Boletin%20epidemiologico%2
0semana%2045.pdf
• 3. The public health Emergency Operations Center report on microcephaly.
Epidemiological Week 47 of 2015. Brazil Ministry of Health. Available at:
http://portalsaude.saude.gov.br/images/pdf/2015/novembro/30/COES-
Microcefalias---Informe-Epidemiol--gico---SE-47---30nov2015.pdf
• 4. Brazil Ministry of Health. Microcephaly – Ministry of Health releases
epidemiological bulletin [Internet]. Available at:
http://portalsaude.saude.gov.br/index.php/cidadao/principal/agencia-saude/20805-
ministerio-da-saude-divulga-boletim-epidemiologico.
REFERENCES
• 5. European Centre for Disease Prevention and Control. Rapid risk assessment: Microcephaly in
Brazil potentially linked to the Zika virus epidemic – 24 November 2015. Stockholm: ECDC; 2015.
Available at: http://ecdc.europa.eu/en/publications/Publications/zika-microcephaly-Brazil-rapid-risk-
assessment-Nov-2015.pdf
• 6. Information provided by the Brazil International Health Regulations (IHR) National Focal Point
(NFP). July 2015.
• 7. Fiocruz Pernambuco answers questions about Zika virus. Agencia Fiocruz de Noticias. Available
at: http://www.agencia.fiocruz.br/fiocruz-pernambuco-esclarece-d%C3%BAvidas-sobre-
v%C3%ADrus-zika
• 8. Bulletin hebdomadaire international du 5 au 11 mars 2014. N°442. Available at:
http://www.invs.sante.fr/Publications-et-outils/Bulletin-hebdomadaire-international/Tous-les-
numeros/2014/Bulletin-hebdomadaire-international-du-5-au-11-mars-2014.-N-442
• 9. Dengue. Guidelines for diagnosis, treatment, prevention and control. World Health Organization,
2009. WHO/HTM/NTD/DEN/2009.1
•THANK YOU FOR
LISTENING

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ZIKA VIRUS

  • 2. OUTLINE: • Definition. • Brief history • Countries affected • Mode of transmission • Symptoms • Population at risk • Complications • Diagnosis • Treatments • Prevention • References
  • 3. DEFINITION: • Zika is a viral disease caused by an arbovirus of the flavivirus family. • Is a mosquito-borne single-stranded RNA virus related to dengue virus • The disease is characterize by: – acute febrile illness similar to dengue fever, – rash, – inflammation of the joints – conjunctivitis.
  • 4. BRIEF HISTORY: • Zika virus was first isolated from a rhesus monkey in Uganda’s Zika Forest in 1947. • The virus is common in: – West and Central Africa – but also occurs in Pakistan, India, Vietnam, – Thailand, the Philippines, Malaysia, Indonesia – and Micronesia.
  • 5. BRIEF HISTORY: • It was isolated for the first time from humans in Nigeria in 1968. • In recent years the virus has spread throughout the Pacific, with outbreaks in: – the Cook Islands – New Caledonia – French Polynesia – Easter Island.
  • 6. BRIEF HISTORY • Only a few imported cases have been reported in Australia, with no locally acquired infections.
  • 7. Countries/territories with reported cases of Zika virus infection in the past nine months and past two months, as of 19 January 2016 • Barbados • Bolivia • Brazil • Cape Verde • Colombia • Ecuador • El Salvador • Fiji* • Puerto Rico • Saint Martin • Samoa • Solomon Islands* • Suriname • French Guiana • Guadeloupe • Guatemala • Guyana • Haiti • Honduras • Maldives* • Martinique • Mexico • New Caledonia* • Panama • Paraguay • Thailand • Venezuela
  • 8. MODES OF TRANSMISSION : • Zika is a disease of monkeys and humans transmitted by mosquitoes: – Aedes africanus isthe vector in forest areas in Africa, while – Aedes aegypti, the dengue mosquito, is the probable vector in other areas. • Aedes albopictus mosquitoes can also transmit the virus. • Aedes mosquitoes are aggressive daytime biters and feed both indoors and outdoors.
  • 9. MODES OF TRANSMISSION • Zika virus can be transmitted locally from: • A pregnant mother to her fetus during pregnancy or around the time of birth. • Person -to-person through blood or sexual contact
  • 10. SYMPTOMS: • Clinical symptoms last for 4-7 days and include: – headache – muscle aches – Maculopapular rash – fever – Conjunctivitis – joint pain mainly joints of the hands and feet) – diarrhoea.
  • 11. POPULATION AT RISK: • Anyone who is living in or traveling to an area where Zika virus is found. • Anyone who has not been previously exposed to the virus.
  • 12. COMPLICATIONS: • Guillain-Barré syndrome: – An increase cases has been documented in areas where the virus is endemic. – direct causal relationship has not been established • Microcephaly: – Avialable data suggests a positive correlation between newborn babies of infected mothers and microcephaly • Intracranial Calcification.
  • 13.
  • 14.
  • 15. DIAGNOSIS • Zika virus RNA detected by RT-PCR in any clinical specimen within the first 3-5 days after the onset of symptoms, • Serological test to detect Zika virus IgM with confirmatory neutralizing antibody titers that are ≥4-fold higher than dengue virus neutralizing antibody titers in serum. • Testing would be considered inconclusive if Zika virus neutralizing antibody titers are < 4-fold higher than dengue virus neutralizing antibody titers. • Serological tests are useful only after five days
  • 16. • There is no specific treatment for the infection but it can be managed symptomatically. • Currently there is no vaccination for the virus. • However, work has already begun in developing one but might take about 10-12 years . TREATMENT
  • 17. PREVENTION • Eliminate potential breeding sites of mosquitoes • Personal protection equipments such as: – Wearing loose, light-coloured protective clothing in outdoor situations, covering feet, legs and arms. – Avoid scents on the body, such as perfume, deodorants and sweat, since these can attract mosquitoes. • Sleep under insecticide treated bed nets. • Although there is no travel restriction imposed on the affected regions by WHO; pregnant women are advised not travel to Zika virus endemic regions within their first trimester.
  • 18. REFERENCES • The public health Emergency Operations Center report on microcephaly. Epidemiological Week 46 of 2015. Brazil Ministry of Health. Available at: http://portalsaude.saude.gov.br/index.php/cidadao/principal/agencia-saude/20925- ministerio-divulga-boletim-epidemiologico • 2. Epidemiological Bulletin. Colombia National Institute of Health. Epidemiological Week 46 of 2015. Available at: http://www.ins.gov.co/boletin- epidemiologico/Boletn%20Epidemiolgico/2015%20Boletin%20epidemiologico%2 0semana%2045.pdf • 3. The public health Emergency Operations Center report on microcephaly. Epidemiological Week 47 of 2015. Brazil Ministry of Health. Available at: http://portalsaude.saude.gov.br/images/pdf/2015/novembro/30/COES- Microcefalias---Informe-Epidemiol--gico---SE-47---30nov2015.pdf • 4. Brazil Ministry of Health. Microcephaly – Ministry of Health releases epidemiological bulletin [Internet]. Available at: http://portalsaude.saude.gov.br/index.php/cidadao/principal/agencia-saude/20805- ministerio-da-saude-divulga-boletim-epidemiologico.
  • 19. REFERENCES • 5. European Centre for Disease Prevention and Control. Rapid risk assessment: Microcephaly in Brazil potentially linked to the Zika virus epidemic – 24 November 2015. Stockholm: ECDC; 2015. Available at: http://ecdc.europa.eu/en/publications/Publications/zika-microcephaly-Brazil-rapid-risk- assessment-Nov-2015.pdf • 6. Information provided by the Brazil International Health Regulations (IHR) National Focal Point (NFP). July 2015. • 7. Fiocruz Pernambuco answers questions about Zika virus. Agencia Fiocruz de Noticias. Available at: http://www.agencia.fiocruz.br/fiocruz-pernambuco-esclarece-d%C3%BAvidas-sobre- v%C3%ADrus-zika • 8. Bulletin hebdomadaire international du 5 au 11 mars 2014. N°442. Available at: http://www.invs.sante.fr/Publications-et-outils/Bulletin-hebdomadaire-international/Tous-les- numeros/2014/Bulletin-hebdomadaire-international-du-5-au-11-mars-2014.-N-442 • 9. Dengue. Guidelines for diagnosis, treatment, prevention and control. World Health Organization, 2009. WHO/HTM/NTD/DEN/2009.1