This document discusses wound classification, types of wound healing, and the wound healing process. It classifies wounds based on degree of contamination and causal agents/morphology. The types of wound healing include first, second, and third intention. The phases of wound healing are the lag/preparatory phase, repair/proliferative phase, and maturation phase. Key elements of wound healing include epithelialization, wound contraction, and connective tissue formation. Factors affecting wound healing and potential wound complications are also outlined.
this is presentation talks about basic & updated advanced wounds care,,,,,,,2nd presentation in my internship..i hope you will get benefit from it ......Dr/ Wadie Madi
this is presentation talks about basic & updated advanced wounds care,,,,,,,2nd presentation in my internship..i hope you will get benefit from it ......Dr/ Wadie Madi
PHYSIOTHERAPY IS AN EXTENSIVE FIELD TO TREAT WOUND BY NON INVASIVE WAYS. IN THIS PRESENTATION WE ATTEMPT TO EXPLAIN VARIOUS THERAPEUTIC MEASURES FOR WOUND CARE AND HEALING.
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
PHYSIOTHERAPY IS AN EXTENSIVE FIELD TO TREAT WOUND BY NON INVASIVE WAYS. IN THIS PRESENTATION WE ATTEMPT TO EXPLAIN VARIOUS THERAPEUTIC MEASURES FOR WOUND CARE AND HEALING.
Jbhzj gccycgccychcvycyxfthvyc4dygih8h me feel so special daughter is in the given questions and answers in love you so much to do but I have to be with me and my friends and my friends are not at
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
2. Wound & Wound Healing
Definition:
Breach in continuality of epithelial lining surface due
to injury & trauma.
Classification of wound:
Depend on degree of contamination.
Depend on causal agents/morphology.
3. Depend on degree of contamination.
Clean wound
Wound without contamination.
(e.g. Clean surgical wound under aseptic condition;
Thyroid, Breast, Lipoma Surgery.)
Clean contaminated wound
Wound with minimal or potential contamination.
(e.g. Surgical wound made on potentially
contaminated area (upper GI surgery-stomach,
biliary)
Traumatic clean wound within six hours after
trauma.)
4. Contaminated wound
Wound with gross contamination.
(e.g. Surgical wound made on contaminated area
(colonic surgery)
Traumatic wound > six hours, with
contaminated soil)
Dirty/ Septic wound
Wound contaminated with pathogenic organisms
(e.g. Wound made on gross sepsis-peritonitis,
abscess)
5. Depend on Causal agents/ Morphology
Incised wound
Due to sharp weapon
Minimal tissue loss, edge opposed together & even
Rapid healing when wound is clean & closed primarily,
increased tensile strength, minimal scar
Lacerated wound
Due to blunt object
Variable amount of tissue loss, haematoma, edge is uneven
& rages
More time need to heal (because of increase tissue loss &
presence of haematoma) reduced tensile strength,
increased scar
6. Crush wound
Tissue crush between two hard objects
Large amount of tissue loss, haematoma, unexpected
amount of devitalised tissue at first, and then loss of tissue
depend on force & extend of crush injury
Delay wound healing, reduced tensile strength, increased
scar
Penetrating wound
Due to sharp & pointed weapon
Minimal tissue loss but can’t expect depth of wound
Increase chance of anaerobic condition-tetanus
7. Types of Wound Healing
First intention
In clean surgical wound/incised wound, wound edge
opposed together by suture wound healing is
rapid from edges as well as base, increased tensile
strength & minimal scar formation
Second intention
In case of contaminated/dirty wound with variable
amount of tissue loss- healing arise from base -
healing is delayed & need long time- reduced tensile
strength, increased scar formation
8. Third intention
In case of contaminated wound with minimal tissue
loss, wound wait to clean as open wound ( due to
infection more susceptible in close wound)- closed
the wound with suture when the wound is clean (
delay primary closure) or secondary closure.
9. Elements of Wound Healing
1. Epithelialization
Migration, proliferation of epithelial tissue from the
edges & epidermal layer of wound to cover the
wound
2. Wound contraction
In open wound, the size of wound become smaller
by contraction of myofibroblast to wound healing
3. Connective tissue formation
Main body of wound is united by synthesis & lysis of
collagen tissue from fibroblast & new capillary
formation ( granulation tissue)
10. Phase of Wound Healing
1. Lag (or) Preparatory phase
First few hours to days of wound- infiltration of
neutrophil & macrophages- demolition of
inflammatory exudate & devitalised tissue
2. Repair (or) Proliferated (or) Fibroblastic phase
First few days of wound- macrophages- attract the
fibroblast & synthesis of collagen tissue &
intercellular ground substance & new formation of
blood vessels ( granulation tissue) filled up the
wound wound healing.
11. 3. Maturation (or) Differentiation phase
Reduced activity of fibroblast & increasing tensile
strength of wound need months to years until
normal tensile strength regained (very rare).
50% to 70% of tensile strength regained by the end
of six months
12. Process of wound healing
Epidermal events
Dermal events
Collagen production
13. Epidermal events
Particularly in surgical wd, incised wd within few hrs
Primary single layer of epithelial cell starts to migrate
from edge to form delicate covering over wd
Followed by epithelial cell proliferation from epidermal
cells
(Implantation dermoid – In small penetrating wd(
needle prick) down growth of epidermal cell –keratin
forming cyst within dermis known as implantation
dermoid
14. Dermal events
Within few hrs, mild acute inflammatory infiltration of
neutrophil into and around wd followed by migration of
macrophages (1-2)hrs after wound
Demolition and removal of inflammatory exudate and
tissue debris
Restoration of tensile strength of sub epithelial
connective tissue
• Chemoattraction of fibroblasts synthesis secretion
of collagen and ground substance
• Expansion of fibroblast population
• Secretion of extracellular connective tissue protein
for fibroblast
15. Ingrowth of new small bld v/s
Budding of new endothelial cell from intact bld v/s of
edges
Chemoattraction of these new bld vs into connective
tissue of wd
16. Collagen production
Over half of collagen made up with 3 amino acids; lysine,
hydroxyprolene, prolene
Fibroblast ; synthesis new collagen intercellular ground
substance production of 3 main amino acids and cross
linkage of each other > connective t/s formation> tensile
strength of wd
17. Tensile strength depends on production of amount of
collagen and their orientation. This process is maintained
by production and destruction of collagen (collagen
synthesis and lysis)
Inbalance between this process>wd complication
Decrease synthesis ,increase lysis > impaired wd
healing and dehiscence
Increased synthesis, decrease lysis > hypertrophic
scar keloid formation
18. Factors affecting wound healing
General factors
(1) Age - young age - increased blood supply- good
wound healing
- old age - reduced blood supply & associated
diseases- impair wound healing
(2) Nutritional status
(1) Overnutrition - (2) Undernutrition
19. (1) Overnutrition - obesity- increased fatty tissue-
(a) reduced supportive tissue to blood vessels- fragile, easy
to bleed
(b) retraction of blood vessel- difficult to control healing
(c) increased tissue destruction, dead space
(2) Undernutrition
hypoproteinaemia- impair amino acid synthesis
hypovitamin C (surgery) – impair collagen synthesis
(hydroxylation)
hypovitamin A – epidermal growth reduced
zinc – impair wound healing- because of decrease collagen
synthesis
20. (3) Associated diseases
-jaundice
-uraemia
-anaemia-reduced Hb – decreased oxygen carrying capacity
-diabetes mellitus – decreased immunity, reduced blood
supply, increased infection
-impaired cardiopulmonary status- reduced oxygen supply to
tissue
(4) Immunity
-reduced immunity- increase infection-
due to disease - burn, DM, HIV, trauma, Ca
due to drugs - steroid, chemotherapy,
immunosuppressive therapy
Increased collagen breakdown
21. Local factors
1. Site- face- increased blood supply- increased wound
healing
2. Presence of foreign body + contamination- increased
infection- reduced oxygen supply- impaired wound
healing
3. Underlying vascular diseases –artery-reduced blood
supply, venous stasis- reduced oxygen supply
4. Presence of tension- reduced blood supply- to
wound- haematoma, dead space
oxygenation
infection
24. Hypertrophic Keloid
Time factor Regress after 6 months Continue after 6 months
Tendency No previous Previous tendency
Site Any site Over the bony prominent
e.g. sternum
Extend beyond the
margin of wound
Never Presence
Treatment No active treatment required Active treatment required –
injection steroid, pressure
dressing, R/T
Complication - Malignant change – Marjolin’s
ulcer
25. Principle of wound management
Clean wound – closed by primary intention
Contaminated wound – change to clean wound –
closed
Depend on - amount of contamination
- type of wound
26. A. Specific treatment
Contaminated wound- change to clean wound by-
1. “wound toilet”- irrigation of wound with sterile water including
antiseptic solution - to reduce contamination & remove foreign
body
2. “wound debridement”- excision of dead & devitalised tissue under
appropriate GA/LA/Reagional
Skin – as little as possible (easy to close the wound)
Subcut :fat & tls – as much as possible
Mls – till bleed ( viable mls )
Tendon – color suture for delayed repair
Nv – primary repair / delayed repair mark with suture
27. Bld v/s -Small v/s – haemostasis
-Major v/s – primary repair / graft
Bone - detached bone & pieces from periosteum
removed
- Reduction & traction by external fixator or POP
with windows for dressing
28. B. Supportive / symptomatic treatment
- Analgesic & antiinflammatory drugs - for pain & inflammation
- Antipyretic drugs – pt with febrile reaction
- Antibiotic – according to possible organ ( or ) C&S result
- tetanus prophylaxis – tetanus toxoid – active for regular
immunized person
– both active & passive in pt who has no
regular immmunization
- Nutritional support
- Correct the factors which delayed the wd healing e.g
Correction of Anaemia, Diabetes mellitus
29. C. Treatment of clean wd / wd become clean from
contaminated wound
- Skin closure d/on type of wound
( 1 ) when skin can oppose together eg .in incise &
lacerated wound ( less tissue loss )
- Primary closure – for clean wound.
- delayed primary closure – for contaminated wound.
30. - secondary closure – clean wound become
contaminated
- after primary closure & remove the suture and then
wait for clean wound and then reapplication of
suture
( 2 ) when skin cannot oppose together (tissue loss very
much) crush wound
a. Close the wound by – skin graft ( to fasten the wd
healing ) ( or )
b. Left the wound open and healing from base of
wound ( wd complication increased )