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WOUND AND WOUND
MANAGEMENT
PRESSENTED BY:
MODERATED BY:
• Def Wound / Ulcer
• Types of wound
• mode of injury
• contamination
• wound healing phase
• factors of wound healing
• Methods of wound healing
Three Phases of Wound Healing
 Inflammatory Phase
 Proliferative Phase
 Remodeling Phase
Three Phases of Wound Healing
• Inflammatory Phase
• Proliferative Phase
• Begins when wound is covered by epithelium
• Production of collagen is hallmark
• 7 days to 6 weeks
• Remodeling Phase (Maturation Phase)
Inflammatory Phase
• Hemostasis and Inflammation
• Days 4 - 6
• Exposed collagen activates clotting cascade and
inflammatory phase
• Fibrin clot = scaffolding and concentrate cytokines
and growth factors
Inflammatory: Granulocytes
• First 48 hours
• Attracted by inflammatory mediators
• Oxygen-derived free radicals
• Non-specific
Inflammatory: Macrophages
• Monocytes
• attracted to area by complement
• Activated by:
• fibrin
• foreign body material
• exposure to hypoxic and acidotic environment
• Reached maximum after 24 hours
• Remain for weeks
Inflammatory: Macrophages
• Activated Macrophage:
• Essential for progression onto Proliferative Phase
• Mediate:
• Angiogenesis: FGF, PDGF, TGF-a&b and TNF-a
• Fibroplasia: IL’s, EGF and TNF
• Synthesize NO
• Secrete collagenases
Review of Wound Healing
• Three basic types of healing
• Primary
• Delayed Primary
• Secondary
Primary
• Wound surfaces opposed
• Healing without complications
• Minimal new tissue
• Results optional
Delayed Primary
• Left open initially
• Edges approximated 4-6 days later
Secondary
• Surfaces not approximated
• Defect filled by granulation
• Covered with epithelium
• Less functional
• More sensitive to thermal and mechanical injury
WOUND AND WOUND MANAGEMENT.pptx
WOUND AND WOUND MANAGEMENT.pptx
WOUND AND WOUND MANAGEMENT.pptx
WOUND AND WOUND MANAGEMENT.pptx
WOUND AND WOUND MANAGEMENT.pptx
WOUND AND WOUND MANAGEMENT.pptx
WOUND AND WOUND MANAGEMENT.pptx
WOUND AND WOUND MANAGEMENT.pptx
WOUND AND WOUND MANAGEMENT.pptx
WOUND AND WOUND MANAGEMENT.pptx
WOUND AND WOUND MANAGEMENT.pptx
WOUND AND WOUND MANAGEMENT.pptx
WOUND AND WOUND MANAGEMENT.pptx
WOUND AND WOUND MANAGEMENT.pptx
WOUND AND WOUND MANAGEMENT.pptx
WOUND AND WOUND MANAGEMENT.pptx
WOUND AND WOUND MANAGEMENT.pptx
WOUND AND WOUND MANAGEMENT.pptx
WOUND AND WOUND MANAGEMENT.pptx
WOUND AND WOUND MANAGEMENT.pptx
WOUND AND WOUND MANAGEMENT.pptx

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WOUND AND WOUND MANAGEMENT.pptx

  • 2. • Def Wound / Ulcer • Types of wound • mode of injury • contamination • wound healing phase • factors of wound healing • Methods of wound healing
  • 3.
  • 4.
  • 5. Three Phases of Wound Healing  Inflammatory Phase  Proliferative Phase  Remodeling Phase
  • 6. Three Phases of Wound Healing • Inflammatory Phase • Proliferative Phase • Begins when wound is covered by epithelium • Production of collagen is hallmark • 7 days to 6 weeks • Remodeling Phase (Maturation Phase)
  • 7. Inflammatory Phase • Hemostasis and Inflammation • Days 4 - 6 • Exposed collagen activates clotting cascade and inflammatory phase • Fibrin clot = scaffolding and concentrate cytokines and growth factors
  • 8. Inflammatory: Granulocytes • First 48 hours • Attracted by inflammatory mediators • Oxygen-derived free radicals • Non-specific
  • 9. Inflammatory: Macrophages • Monocytes • attracted to area by complement • Activated by: • fibrin • foreign body material • exposure to hypoxic and acidotic environment • Reached maximum after 24 hours • Remain for weeks
  • 10. Inflammatory: Macrophages • Activated Macrophage: • Essential for progression onto Proliferative Phase • Mediate: • Angiogenesis: FGF, PDGF, TGF-a&b and TNF-a • Fibroplasia: IL’s, EGF and TNF • Synthesize NO • Secrete collagenases
  • 11. Review of Wound Healing • Three basic types of healing • Primary • Delayed Primary • Secondary
  • 12. Primary • Wound surfaces opposed • Healing without complications • Minimal new tissue • Results optional
  • 13. Delayed Primary • Left open initially • Edges approximated 4-6 days later
  • 14. Secondary • Surfaces not approximated • Defect filled by granulation • Covered with epithelium • Less functional • More sensitive to thermal and mechanical injury