Wilm's tumor and nephrotic syndrome are kidney disorders that mainly affect children. Wilm's tumor is a type of childhood kidney cancer that arises from renal parenchyma. Nephrotic syndrome is characterized by proteinuria, hypoalbuminemia, and edema. Both conditions are associated with genetic factors and present with nonspecific symptoms like fever, nausea, and abdominal masses. Diagnosis involves medical imaging and biopsy. Treatment consists of chemotherapy, surgery, radiation, and steroids depending on the stage or type of disease. Ongoing research aims to further understand the genetic causes and develop more targeted therapies to improve cure rates and reduce long-term side effects.