Dengue serotype 1,2,3,4
1 2 3 4 5 6 7 8 9 10
40 C
Dehydration
Reabsorption
Fluid overload
Organ impairment
Days
Temperature
Potential clinical issues
Laboratory changes
Serology & virology
Hematocrit
Platelets
Viraemia
IgM/IgG
Febrile Critical Recovery
Course of Dengue illness
4-10 days after mosquito bite
Shock
Bleeding
With
warning
signs
Without
Severe plasma leakage
Severe hemorrhage
Severe organ damage
Probable dengue
Nausea, Vomiting
Rash
Aches/pain
Tourniquet test +
Warning signs
Abd pain/tenderness
Persistent vomiting
Mucosal bleed
Lethargy/Liver size↑
HCT↑∕Platelet↓
Severe Plasma leakage
DSS
Respiratory distress
Severe bleeding
Evaluated by clinicians
Severe organ damage
Liver: AST/ALT >=1000
CNS: consciousness↓
Dengue case classification by severity
PCR
NS1 Antigen
ELISA
Rapid test
ELISA
Virus/Antigen detection ( 1-2 days ←fever→5-6 days)
IgM for recent infection (3-6 days after fever onset)
IgG for past dengue infection or secondary infection
Dengue Diagnosis
Dengue
without
warning signs
Dengue with
warning signs
Severe Dengue
Bed rest
↑Fluid intake
Paracetamol
as necessary
Home care Hospital care
Observation
↑Fluid intake/IV
Monitor vital signs/I-O
Monitor Hct 2-4 hrly
Emergency + Hospital care
Fluid resuscitation
Monitor vital signs/I-O
Monitor Hct hrly
Blood transfusion
as necessary
Dengue Management
Clear blockagesTurn over container
Remove waterChange water in vase
Adult
Pupae
Larvae
Egg
2-7 days
>4 days
2 days
Dengue Prevention

Dengue

  • 2.
  • 3.
    1 2 34 5 6 7 8 9 10 40 C Dehydration Reabsorption Fluid overload Organ impairment Days Temperature Potential clinical issues Laboratory changes Serology & virology Hematocrit Platelets Viraemia IgM/IgG Febrile Critical Recovery Course of Dengue illness 4-10 days after mosquito bite Shock Bleeding
  • 4.
    With warning signs Without Severe plasma leakage Severehemorrhage Severe organ damage Probable dengue Nausea, Vomiting Rash Aches/pain Tourniquet test + Warning signs Abd pain/tenderness Persistent vomiting Mucosal bleed Lethargy/Liver size↑ HCT↑∕Platelet↓ Severe Plasma leakage DSS Respiratory distress Severe bleeding Evaluated by clinicians Severe organ damage Liver: AST/ALT >=1000 CNS: consciousness↓ Dengue case classification by severity
  • 5.
    PCR NS1 Antigen ELISA Rapid test ELISA Virus/Antigendetection ( 1-2 days ←fever→5-6 days) IgM for recent infection (3-6 days after fever onset) IgG for past dengue infection or secondary infection Dengue Diagnosis
  • 6.
    Dengue without warning signs Dengue with warningsigns Severe Dengue Bed rest ↑Fluid intake Paracetamol as necessary Home care Hospital care Observation ↑Fluid intake/IV Monitor vital signs/I-O Monitor Hct 2-4 hrly Emergency + Hospital care Fluid resuscitation Monitor vital signs/I-O Monitor Hct hrly Blood transfusion as necessary Dengue Management
  • 7.
    Clear blockagesTurn overcontainer Remove waterChange water in vase Adult Pupae Larvae Egg 2-7 days >4 days 2 days Dengue Prevention