What are the five signs of tissue injury? Solution Ans: The five signs of tissue injury are: 1. Discomfort or pain which is usually worse with movement in the affected area. 2. Swelling to varying degrees over the affected area and surronding regions. 3. Tenderness with pressure on the affected area. 4. Bruising (discolouration of skin) over the affected area. 5. Weakness and instability in the affected area..