When Worlds Collide discusses the momentous events of 1492, when Christopher Columbus arrived in the Americas, connecting two worlds that had developed independently for thousands of years. The arrival of Europeans forever altered life for the indigenous peoples of the Americas and led to the exchange of commodities between the two worlds, fueling economic growth in Europe. It also examines the decline of the vast Spanish Empire in the late 1500s as it relinquished its role as the world's sole superpower.