Founded in 1988, Pyramid Laboratories, Inc., is a contract parenteral drug manufacturer and analytical provider that serves both the pharmaceutical and biotechnology industries. Among the Pyramid Laboratories, Inc., offerings is its equipment, including a laboratory-scale lyophilizer as well as a differential scanning calorimeter, along with a team of scientists to optimize the formulation of the product for lyophilization, also known as freeze-drying.
2. Introduction
Founded in 1988, Pyramid Laboratories, Inc., is a
contract parenteral drug manufacturer and analytical
provider that serves both the pharmaceutical and
biotechnology industries. Among the Pyramid
Laboratories, Inc., offerings is its equipment, including
a laboratory-scale lyophilizer as well as a differential
scanning calorimeter, along with a team of scientists
to optimize the formulation of the product for
lyophilization, also known as freeze-drying.
Since ice is less dense than water, freezing anything
that contains water under normal conditions results in
damage to the container as the water expands inside
it during freezing, then contracts as it thaws.
3. Lyophilization
Lyophilization is a method of freeze-drying
preferred by biotechnology and pharmaceutical
firms for products whose physical structure is
vulnerable to damage during the freezing process.
Lyophilization is achieved through the application
of a low-temperature as well as a low-pressure
environment. This takes advantage of the fact that
at low pressures, ice turns to gas, or sublimes.
Therefore, once the product is frozen, the
pressure of the container is lowered to a point
where the water within it turns directly to gas. This
results in a freeze-dried product that can be easily
re-hydrated.