This document summarizes the findings of a systematic review and meta-analysis of research on effective distance, online, and blended teaching and learning. The review identified five prominent themes in the literature: comparisons of distance/online and face-to-face instruction; factors affecting effectiveness; institutional adoption; research methods; and topic analysis. Key findings included that distance education can be as effective as traditional instruction, especially when incorporating interaction and collaboration. Blended learning showed particularly positive results. Effectiveness has increased over time with improvements in technology and pedagogy. However, more support is still needed for instructors to develop new competencies for online facilitation.