West Nile virus is an arbovirus spread by infected mosquitoes that can cause febrile illness, encephalitis, or meningitis. It was first identified in Africa in 1937 and outbreaks occurred in Algeria in 1994 and Romania in 1996. The first case in the United States was detected in New York City in 1999, after which it spread across the continental US, into Canada, and parts of the Caribbean and Latin America over the next 5 years.