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Stratall ANRS 12110 / ESTHER trial   A randomised trial comparing  a public-health approach  to a standard clinical approach  in delivering antiretroviral therapy C. Kouanfack, C. Laurent, G. Laborde-Balen,  A. F. Aghokeng, A. Bourgeois, S. Kazé, J-M. Mben,  M. Dontsop, E. Mpoudi-Ngolé, S. Koulla-Shiro, E. Delaporte  for the Stratall ANRS 12110 / ESTHER Study Group.
Antiretroviral therapy coverage in low- and middle-income countries, December 2007 31% [27–34%] 9 700 000 [8.7–11.0 million] 2 990 000   [2.7–3.3 million] Total 7% 100 000 7 000 North Africa and the Middle East 17% 320 000   54 000 Europe and Central Asia 25% 1 700 000 420 000 East, South and South-East Asia 62% 630 000   390 000 Latin America and the Caribbean 30% 7 000 000 2 120 000 Sub-Saharan Africa         Coverage Estimated need Number of people receiving  ARV therapy Geographical Region
Standard clinical approach ,[object Object],[object Object],[object Object],[object Object],[object Object]
Limitations of the clinical approach ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Public-health approach (WHO) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Controversy ,[object Object],[object Object],[object Object],[object Object],[object Object]
Objectives ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Study design ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Inclusion criteria ,[object Object],[object Object],[object Object],[object Object],[object Object]
Assessment of effectiveness ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical exams ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Baseline characteristics of patients (n=459) Women 70.6% Median age (IQR) 36.9 (30.2-44.8) WHO clinical stage 2 3 4 0.2% 73.2% 26.6% Median CD4 cell count (IQR) 181 (87-336) Median HIV-1 RNA level (IQR) 5.6 (5.1-6.0)
Survival 0.00 0.25 0.50 0.75 1.00 0 90 180 270 360 Days
Deaths or stage 3 or 4 events 0.00 0.25 0.50 0.75 1.00 0 90 180 270 360 Days
ART change 0.00 0.25 0.50 0.75 1.00 0 90 180 270 360 Days
Discussion  1/2 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Discussion  2/2 Other ongoing studies. ,[object Object],[object Object],[object Object],[object Object]
Conclusion ,[object Object],[object Object]
Thank you for your kind attention

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Wesat2003

  • 1. Stratall ANRS 12110 / ESTHER trial A randomised trial comparing a public-health approach to a standard clinical approach in delivering antiretroviral therapy C. Kouanfack, C. Laurent, G. Laborde-Balen, A. F. Aghokeng, A. Bourgeois, S. Kazé, J-M. Mben, M. Dontsop, E. Mpoudi-Ngolé, S. Koulla-Shiro, E. Delaporte for the Stratall ANRS 12110 / ESTHER Study Group.
  • 2. Antiretroviral therapy coverage in low- and middle-income countries, December 2007 31% [27–34%] 9 700 000 [8.7–11.0 million] 2 990 000 [2.7–3.3 million] Total 7% 100 000 7 000 North Africa and the Middle East 17% 320 000   54 000 Europe and Central Asia 25% 1 700 000 420 000 East, South and South-East Asia 62% 630 000   390 000 Latin America and the Caribbean 30% 7 000 000 2 120 000 Sub-Saharan Africa         Coverage Estimated need Number of people receiving ARV therapy Geographical Region
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11.
  • 12.
  • 13. Baseline characteristics of patients (n=459) Women 70.6% Median age (IQR) 36.9 (30.2-44.8) WHO clinical stage 2 3 4 0.2% 73.2% 26.6% Median CD4 cell count (IQR) 181 (87-336) Median HIV-1 RNA level (IQR) 5.6 (5.1-6.0)
  • 14. Survival 0.00 0.25 0.50 0.75 1.00 0 90 180 270 360 Days
  • 15. Deaths or stage 3 or 4 events 0.00 0.25 0.50 0.75 1.00 0 90 180 270 360 Days
  • 16. ART change 0.00 0.25 0.50 0.75 1.00 0 90 180 270 360 Days
  • 17.
  • 18.
  • 19.
  • 20. Thank you for your kind attention