2023 Undergraduate Research Symposium: Taral Patel and Sophie Habashy
Asthma negatively affects the quality of life of those who suffer from it, with the acknowledgment that the African American/Black community is disproportionately afflicted by the disease. Research suggests that increased atmospheric particulate matter among other pollutants is correlated with higher rates of reported asthma symptoms and hospitalizations.
The present study describes the methodology of cross-referencing Environmental Protection Agency (EPA) reported daily particulate matter 2.5 (PM2.5) with participant laboratory visits with the goal of allowing researchers to assess the effect of this pollutant with concurrent reports of psychosocial and asthma measures. Part of this data comes from the Asthma in the Lives of Families Today study which investigated psychosocial predictors of asthma-related health among African American children from the Detroit area between 2011-2018. Determining PM2.5 levels on lab visit days was conducted in multiple steps. Firstly, participants' zip codes were used to determine their geographical census block (i.e., GEOID). Next, GEOIDs were matched to the most closely located EPA PM2.5 sites of the twelve stationed in Wayne County.
After the EPA site was matched to the participant, the PM2.5 measurement on the day of each participant's ALOFT visit was identified. This methodological approach provided a clear air pollution reference on the date of lab visits, allowing ALOFT researchers to investigate its specific and subsequent impact on child asthma health.
Cómo distinguir una investigación seria de una fraudulentaantenasysalud
Segunda presentación del Dr. Mike Repacholi, presidente emérito del ICNIPR (Comisión Internacional de Protección contra la Radiación No Ionizante) y Miembro del Comité Asesor Internacional del Proyecto de EMF Internacional de la Organización Mundial de la Salud, durante el II Foro Internacional “Antenas y Telecomunicaciones; Inclusiòn, Desarrollo y Salud Humana. Repacholi ofreció una disertación focalizada a resaltar las diferencias entre investigaciones científicas serias y fraudulentas que muchas veces ganan gran atención de la prensa generando temor entre la población respecto a las presuntas relaciones entre la radiación que emiten las antenas y sus efectos en la salud.
L’aria è elemento essenziale per la vita dell’uomo.La “mission” di questo blog è quello di soddisfare le esigenze di ricerca e di conoscenza delle tecnologie che possono permettere alle persone di respirare ogni giorno un’aria più pulita e sana, migliorando la qualità e la durata della loro vita.
Cómo distinguir una investigación seria de una fraudulentaantenasysalud
Segunda presentación del Dr. Mike Repacholi, presidente emérito del ICNIPR (Comisión Internacional de Protección contra la Radiación No Ionizante) y Miembro del Comité Asesor Internacional del Proyecto de EMF Internacional de la Organización Mundial de la Salud, durante el II Foro Internacional “Antenas y Telecomunicaciones; Inclusiòn, Desarrollo y Salud Humana. Repacholi ofreció una disertación focalizada a resaltar las diferencias entre investigaciones científicas serias y fraudulentas que muchas veces ganan gran atención de la prensa generando temor entre la población respecto a las presuntas relaciones entre la radiación que emiten las antenas y sus efectos en la salud.
L’aria è elemento essenziale per la vita dell’uomo.La “mission” di questo blog è quello di soddisfare le esigenze di ricerca e di conoscenza delle tecnologie che possono permettere alle persone di respirare ogni giorno un’aria più pulita e sana, migliorando la qualità e la durata della loro vita.
Exposure to outdoor air pollution and its effect.pptxdipakghimire77
Outdoor air pollution is a complex and pervasive environmental issue that affects millions of people worldwide. The continuous release of pollutants into the atmosphere from various sources has led to widespread exposure, contributing to a range of health problems. This comprehensive review explores the sources, composition, and health effects of outdoor air pollution, emphasizing the significance of addressing this global challenge.
RESEARCH Open AccessExposures to fine particulate air poll.docxronak56
RESEARCH Open Access
Exposures to fine particulate air pollution and
respiratory outcomes in adults using two national
datasets: a cross-sectional study
Keeve E Nachman1* and Jennifer D Parker2
Abstract
Background: Relationships between chronic exposures to air pollution and respiratory health outcomes have yet
to be clearly articulated for adults. Recent data from nationally representative surveys suggest increasing disparity
by race/ethnicity regarding asthma-related morbidity and mortality. The objectives of this study are to evaluate the
relationship between annual average ambient fine particulate matter (PM2.5) concentrations and respiratory
outcomes for adults using modeled air pollution and health outcome data and to examine PM2.5 sensitivity across
race/ethnicity.
Methods: Respondents from the 2002-2005 National Health Interview Survey (NHIS) were linked to annual kriged
PM2.5 data from the USEPA AirData system. Logistic regression was employed to investigate increases in ambient
PM2.5 concentrations and self-reported prevalence of respiratory outcomes including asthma, sinusitis and chronic
bronchitis. Models included health, behavioral, demographic and resource-related covariates. Stratified analyses
were conducted by race/ethnicity.
Results: Of nearly 110,000 adult respondents, approximately 8,000 and 4,000 reported current asthma and recent
attacks, respectively. Overall, odds ratios (OR) for current asthma (0.97 (95% Confidence Interval: 0.87-1.07)) and
recent attacks (0.90 (0.78-1.03)) did not suggest an association with a 10 μg/m3 increase in PM2.5. Stratified analyses
revealed significant associations for non-Hispanic blacks [OR = 1.73 (1.17-2.56) for current asthma and OR = 1.76
(1.07-2.91) for recent attacks] but not for Hispanics and non-Hispanic whites. Significant associations were observed
overall (1.18 (1.08-1.30)) and in non-Hispanic whites (1.31 (1.18-1.46)) for sinusitis, but not for chronic bronchitis.
Conclusions: Non-Hispanic blacks may be at increased sensitivity of asthma outcomes from PM2.5 exposure.
Increased chronic PM2.5 exposures in adults may contribute to population sinusitis burdens.
Keywords: Particulate matter, Asthma, Sinusitis, Air pollution, National Health Interview Survey (NHIS)
Background
Relationships between exposure to particulate air pollu-
tion and a variety of adverse effects, including cardiovas-
cular and respiratory diseases, birth outcomes, genetic
polymorphisms, as well as mortality and life expectancy
have been studied [1-8]. A number of studies have
investigated the influence of exposure to particulate
matter on development of respiratory outcomes, though
the majority focus on children [9-13]; a limited number
of published reports exist documenting of the effects of
chronic exposures on non-cancer respiratory outcomes
in adults [14-17].
National prevalence data for several respiratory condi-
tions are available from the National Center for Health
Statistics (NCHS) of the Ce ...
Liberty UniversityMaster of Public HealthHealth 625Prevent.docxcroysierkathey
Liberty University
Master of Public Health
Health 625
Prevention and Control of Infectious Diseases
STUDYING RISK FACTORS ASSOCIATED WITH HUMAN LEPTOSPIROSIS (Kamath R et al.):
AN ARTICLE REVIEW
IMA STUDENT
ID: XOXOXO
November 4, 2014
Words: 951
Article: Kamath R, Swain S, Nair SN, Pattanshetty S. Studying risk factors associated with human Leptospirosis. J Glob Infect Dis.2014; 6(1): 3–9. doi:10.4103/0974-777X.127941.
I. SUMMARY
The article presents the findings of a matched case-control study conducted to identify the occupational and environmental risk factors of Leptospirosis in India. The study was conducted from April 2012 to August 2012 with a total of 70 cases and 140 sex matched controls belonging to the same neighborhoods as cases.
Data collection on occupational and environmental risk factors was achieved through semi-structured questionnaires and researcher observation.
The study revealed that certain occupational and environmental factors were significantly associated with Leptospirosis and were therefore risk factors for this disease. Of all risk factors, the presence of a wound or cut in the skin while working was found to have the strongest association with Leptospirosis. This was followed by contact with soil contaminated with infected rodent urine. Occupations involving outdoor activities were significant risk factors for Leptospirosis compared to those involving indoor tasks. Other significant risk factors were the presence of drainage or sewage within a 15m radius from the home as well as the ingestion of inadequately cooked or raw vegetables with rat bites.
II. ARTICLE REVIEW
This article review examines the research methodology, study findings as well as the limitations of the study. Findings are analyzed using evidence from similar studies and recommendations are provided to address the identified limitations.
Review of Methodology
The case-control approach was used to determine risk factors of Leptospirosis. While this method is not very rigorous compared to other study designs, it is useful in the study of outbreaks and rare or neglected diseases such as Leptospirosis. This method is also appropriate where the small sample size and inadequate resources limit the use of more rigorous designs.
The control of confounders was achieved by matching cases and controls according to gender, age and geographic location. 1 While researchers identified the three main confounders, confounding by religion was not controlled, in fact majority of participants belonged to one religion. This may have been a result of selecting cases and controls from the same neighborhood. Religion may be a risk factor of Leptospirosis especially if it involves rituals or practices where members come in contact with contaminated rivers, water or soil.
Data collection was done through the use of semi-structured questionnaires and researcher observation. 1 While semi-structured questionnaires allow researchers to obtain substantial in ...
264 volume 123 number 3 March 2015 • Environmental Health .docxeugeniadean34240
264 volume 123 | number 3 | March 2015 • Environmental Health Perspectives
Research | Children’s Health A Section 508–conformant HTML version of this article is available at http://dx.doi.org/10.1289/ehp.1408133.
Introduction
Autism spectrum disorder (ASD) is a
developmental disorder with increasing
reported prevalence worldwide (French et al.
2013). Although genetics plays a strong role
in ASD, evidence suggests that environmental
exposures, particularly in utero or during early
life, also affect ASD risk (Grønborg et al.
2013; Hallmayer et al. 2011; Quaak et al.
2013). However, no specific environmental
toxicant has been consistently associated with
increased risk of ASD.
Air pollution contains various toxicants
that have been found to be associated with
neurotoxicity and adverse effects on the fetus
in utero (Crump et al. 1998; Grandjean and
Landrigan 2006; Rice and Barone 2000;
Rodier 1995; Stillerman et al. 2008). Airborne
particles are covered with various contami-
nants, and have been found to penetrate the
subcellular environment and induce oxidative
stress and mitochondrial damage in vitro (Li
et al. 2003; MohanKumar et al. 2008). In
rodents, these particles also have been found
to stimulate inflammatory cytokine release
systemically and in the brain, and alter the
neonatal immune system (Hertz-Picciotto
et al. 2005, 2008; MohanKumar et al.
2008)—processes that have been implicated
in ASD (Depino 2013; Napoli et al. 2013).
Several studies have explored associations
of air pollution with ASD, using the U.S.
Environmental Protection Agency (EPA)
hazardous air pollutant models, distance to
freeway, or local models for specific pollutants.
These studies suggest increased odds of having a
child with ASD with higher exposures to diesel
particulate matter (PM) (Roberts et al. 2013;
Windham et al. 2006), several metals (Roberts
et al. 2013; Windham et al. 2006), criteria
pollutants (Becerra et al. 2013; Volk et al.
2013), and some organic materials as well as
closer proximity to a freeway (Volk et al. 2011).
Our goal was to explore the association
between ASD and exposure to PM during
defined time periods before, during, and
after pregnancy, within the Nurses’ Health
Study II (NHS II), a large, well-defined
cohort with detailed residential history. This
nested case–control study includes partici-
pants from across the continental United
States, and exposure was linked to monthly
data on two size fractions of PM.
Methods
Participants. The study population included
offspring of participants in NHS II, a
prospective cohort of 116,430 U.S. female
nurses 25–43 years of age when recruited
in 1989, followed biennially (Solomon
et al. 1997). NHS II participants originally
were recruited from 14 states in all regions
of the continental United States, but they
now reside in all 50 states. The study was
approved by the Partners Health Care
Institutional Review Board and complied
with a.
HLTH 625Journal Article Reviews InstructionsReview and analyze.docxpooleavelina
HLTH 625
Journal Article Reviews Instructions
Review and analyze a recent journal article (published within the last 5 years) from a peer-reviewed publication (e.g The Journal of Infectious Diseases) about a TYPHOID FEVER.
· You must evaluate the chosen paper against at least 4 other peer-reviewed sources.
· You may cite your text; however, it does not count as one of your peer-reviewed sources.
· For each review, you will select an article about a topic from the required readings between each review assignment submission.
· You will then compose a 4 -page paper, not including the cover page and references, on your topic of choice.
· The goal of the assignment is to help link the current best practices identified in your text and the ongoing developments of research reflected in the peer-reviewed literature in support of learning outcomes A and B.
· You should, therefore, choose articles related to current epidemiologic trends for infectious diseases and/or the impact of the diseases and of the control measures on global populations. Special attention should be devoted to understanding the role of infectious agents as causes of morbidity and mortality in the context of economically developing nations.
Be sure to include the following elements:
· A clearly documented reference to best practices or standard of care
· Reported findings are completely and fairly assessed and critiqued
· A summary of the principal contents of the article under review
· Adequate information to understand the central themes and recommendations
· Paper, references, and citations all consistently follow current AMA formatting
Liberty University
Master of Public Health
Health 625
Prevention and Control of Infectious Diseases
STUDYING RISK FACTORS ASSOCIATED WITH HUMAN LEPTOSPIROSIS (Kamath R et al.):
AN ARTICLE REVIEW
IMA STUDENT
ID: XOXOXO
November 4, 2014
Words: 951
Article: Kamath R, Swain S, Nair SN, Pattanshetty S. Studying risk factors associated with human Leptospirosis. J Glob Infect Dis.2014; 6(1): 3–9. doi:10.4103/0974-777X.127941.
I. SUMMARY
The article presents the findings of a matched case-control study conducted to identify the occupational and environmental risk factors of Leptospirosis in India. The study was conducted from April 2012 to August 2012 with a total of 70 cases and 140 sex matched controls belonging to the same neighborhoods as cases.
Data collection on occupational and environmental risk factors was achieved through semi-structured questionnaires and researcher observation.
The study revealed that certain occupational and environmental factors were significantly associated with Leptospirosis and were therefore risk factors for this disease. Of all risk factors, the presence of a wound or cut in the skin while working was found to have the strongest association with Leptospirosis. This was followed by contact with soil contaminated with infected rodent urine. Occupations involving outdoor activities were significant ...
Identifying and Prioritizing Chemicals with Uncertain Burden oMalikPinckney86
Identifying and Prioritizing Chemicals with Uncertain Burden of Exposure:
Opportunities for Biomonitoring and Health-Related Research
Edo D. Pellizzari,1 Tracey J. Woodruff,2 Rebecca R. Boyles,3 Kurunthachalam Kannan,4 Paloma I. Beamer,5 Jessie P. Buckley,6
Aolin Wang,2 Yeyi Zhu,7,8 and Deborah H. Bennett9 (Environmental influences on Child Health Outcomes)
1Fellow Program, RTI International, Research Triangle Park, North Carolina, USA
2Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San
Francisco, San Francisco, California, USA
3Bioinformatics and Data Science, RTI International, Research Triangle Park, North Carolina, USA
4Wadsworth Center, New York State Department of Health, Albany, New York, USA
5Department of Community, Environment and Policy, Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, USA
6Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Heath, Johns Hopkins University,
Baltimore, Maryland, USA
7Northern California Division of Research, Kaiser Permanente, Oakland, California, USA
8Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA
9Department of Public Health Sciences, University of California, Davis, Davis, California, USA
BACKGROUND: The National Institutes of Health’s Environmental influences on Child Health Outcomes (ECHO) initiative aims to understand the
impact of environmental factors on childhood disease. Over 40,000 chemicals are approved for commercial use. The challenge is to prioritize chemi-
cals for biomonitoring that may present health risk concerns.
OBJECTIVES: Our aim was to prioritize chemicals that may elicit child health effects of interest to ECHO but that have not been biomonitored nation-
wide and to identify gaps needing additional research.
METHODS: We searched databases and the literature for chemicals in environmental media and in consumer products that were potentially toxic. We
selected chemicals that were not measured in the National Health and Nutrition Examination Survey. From over 700 chemicals, we chose 155 chemi-
cals and created eight chemical panels. For each chemical, we compiled biomonitoring and toxicity data, U.S. Environmental Protection Agency ex-
posure predictions, and annual production usage. We also applied predictive modeling to estimate toxicity. Using these data, we recommended
chemicals either for biomonitoring, to be deferred pending additional data, or as low priority for biomonitoring.
RESULTS: For the 155 chemicals, 97 were measured in food or water, 67 in air or house dust, and 52 in biospecimens. We found in vivo endocrine, de-
velopmental, reproductive, and neurotoxic effects for 61, 74, 47, and 32 chemicals, respectively. Eighty-six had data from high-throughput in vitro
assays. Positive results for endocrine, developmental, neurotoxicity, ...
This is basically a protocol upon the basis of P.G Public Health presentation on behalf of the Health effects due to environmental pollution on population.
2023 Undergraduate Research Symposium: Lane Belden and Bex Watson
The term folkhemmet or “the people’s home” is a Swedish political term that has enjoyed a wide usage amongst various political parties along with the development of the modern Swedish state over the past century. This project aims to define the term and describe its usage through the analysis of both primary and secondary sources.
The term is explored as a uniquely Swedish cultural phenomenon, with both populism and collectivism being explored as avenues to account for the seemingly contradictory usage of the term by opposing political parties. A timeline of the term is created to demonstrate its shifting associations.
2023 Undergraduate Research Symposium: Morgan Grougan
Amidst the ever-expanding cosmos of scientific literature, the quest for tools that can deftly extract and analyze data from publications has grown increasingly vital. Enter LoA (Librarian of Alexandria), a Linux-Python tool that harnesses the power of artificial intelligence to scour chemistry-related papers, meticulously extracting invaluable textual measurements and data into structured Excel files.
This approach engenders the formation of an expansive, high-quality dataset, poised to train predictive models in assessing the properties of chemicals, proteins, and other compounds, with a predominant emphasis on the field of chemistry. LoA's sophisticated AI algorithms artfully decipher and extract essential information from intricate scientific documents. Although the tool currently focuses on extracting text, plans for future iterations include deciphering images and delving into deeper analysis. LoA's potential transcends the realm of chemistry, with prospective applications in diverse scientific disciplines such as materials science, biology, and pharmacology, by tailoring the extraction process to the domain at hand.
Like the ancient Library of Alexandria, LoA aspires to become a beacon of knowledge, a comprehensive instrument for navigating the vast ocean of human intellect. As it is presented at an undergraduate research symposium, this innovative tool embodies the potential for revolutionizing scientific research, opening doors to interdisciplinary applications, and illuminating the path to discoveries yet unimagined. Embracing the beauty of imperfection, LoA continues to evolve, a testament to the resilience and adaptability that characterizes the boundless realm of scientific inquiry.
More Related Content
Similar to Wayne County PM2.5 Levels on Lab Visit Days Among Youth With Asthma: A Methodological Approach
Exposure to outdoor air pollution and its effect.pptxdipakghimire77
Outdoor air pollution is a complex and pervasive environmental issue that affects millions of people worldwide. The continuous release of pollutants into the atmosphere from various sources has led to widespread exposure, contributing to a range of health problems. This comprehensive review explores the sources, composition, and health effects of outdoor air pollution, emphasizing the significance of addressing this global challenge.
RESEARCH Open AccessExposures to fine particulate air poll.docxronak56
RESEARCH Open Access
Exposures to fine particulate air pollution and
respiratory outcomes in adults using two national
datasets: a cross-sectional study
Keeve E Nachman1* and Jennifer D Parker2
Abstract
Background: Relationships between chronic exposures to air pollution and respiratory health outcomes have yet
to be clearly articulated for adults. Recent data from nationally representative surveys suggest increasing disparity
by race/ethnicity regarding asthma-related morbidity and mortality. The objectives of this study are to evaluate the
relationship between annual average ambient fine particulate matter (PM2.5) concentrations and respiratory
outcomes for adults using modeled air pollution and health outcome data and to examine PM2.5 sensitivity across
race/ethnicity.
Methods: Respondents from the 2002-2005 National Health Interview Survey (NHIS) were linked to annual kriged
PM2.5 data from the USEPA AirData system. Logistic regression was employed to investigate increases in ambient
PM2.5 concentrations and self-reported prevalence of respiratory outcomes including asthma, sinusitis and chronic
bronchitis. Models included health, behavioral, demographic and resource-related covariates. Stratified analyses
were conducted by race/ethnicity.
Results: Of nearly 110,000 adult respondents, approximately 8,000 and 4,000 reported current asthma and recent
attacks, respectively. Overall, odds ratios (OR) for current asthma (0.97 (95% Confidence Interval: 0.87-1.07)) and
recent attacks (0.90 (0.78-1.03)) did not suggest an association with a 10 μg/m3 increase in PM2.5. Stratified analyses
revealed significant associations for non-Hispanic blacks [OR = 1.73 (1.17-2.56) for current asthma and OR = 1.76
(1.07-2.91) for recent attacks] but not for Hispanics and non-Hispanic whites. Significant associations were observed
overall (1.18 (1.08-1.30)) and in non-Hispanic whites (1.31 (1.18-1.46)) for sinusitis, but not for chronic bronchitis.
Conclusions: Non-Hispanic blacks may be at increased sensitivity of asthma outcomes from PM2.5 exposure.
Increased chronic PM2.5 exposures in adults may contribute to population sinusitis burdens.
Keywords: Particulate matter, Asthma, Sinusitis, Air pollution, National Health Interview Survey (NHIS)
Background
Relationships between exposure to particulate air pollu-
tion and a variety of adverse effects, including cardiovas-
cular and respiratory diseases, birth outcomes, genetic
polymorphisms, as well as mortality and life expectancy
have been studied [1-8]. A number of studies have
investigated the influence of exposure to particulate
matter on development of respiratory outcomes, though
the majority focus on children [9-13]; a limited number
of published reports exist documenting of the effects of
chronic exposures on non-cancer respiratory outcomes
in adults [14-17].
National prevalence data for several respiratory condi-
tions are available from the National Center for Health
Statistics (NCHS) of the Ce ...
Liberty UniversityMaster of Public HealthHealth 625Prevent.docxcroysierkathey
Liberty University
Master of Public Health
Health 625
Prevention and Control of Infectious Diseases
STUDYING RISK FACTORS ASSOCIATED WITH HUMAN LEPTOSPIROSIS (Kamath R et al.):
AN ARTICLE REVIEW
IMA STUDENT
ID: XOXOXO
November 4, 2014
Words: 951
Article: Kamath R, Swain S, Nair SN, Pattanshetty S. Studying risk factors associated with human Leptospirosis. J Glob Infect Dis.2014; 6(1): 3–9. doi:10.4103/0974-777X.127941.
I. SUMMARY
The article presents the findings of a matched case-control study conducted to identify the occupational and environmental risk factors of Leptospirosis in India. The study was conducted from April 2012 to August 2012 with a total of 70 cases and 140 sex matched controls belonging to the same neighborhoods as cases.
Data collection on occupational and environmental risk factors was achieved through semi-structured questionnaires and researcher observation.
The study revealed that certain occupational and environmental factors were significantly associated with Leptospirosis and were therefore risk factors for this disease. Of all risk factors, the presence of a wound or cut in the skin while working was found to have the strongest association with Leptospirosis. This was followed by contact with soil contaminated with infected rodent urine. Occupations involving outdoor activities were significant risk factors for Leptospirosis compared to those involving indoor tasks. Other significant risk factors were the presence of drainage or sewage within a 15m radius from the home as well as the ingestion of inadequately cooked or raw vegetables with rat bites.
II. ARTICLE REVIEW
This article review examines the research methodology, study findings as well as the limitations of the study. Findings are analyzed using evidence from similar studies and recommendations are provided to address the identified limitations.
Review of Methodology
The case-control approach was used to determine risk factors of Leptospirosis. While this method is not very rigorous compared to other study designs, it is useful in the study of outbreaks and rare or neglected diseases such as Leptospirosis. This method is also appropriate where the small sample size and inadequate resources limit the use of more rigorous designs.
The control of confounders was achieved by matching cases and controls according to gender, age and geographic location. 1 While researchers identified the three main confounders, confounding by religion was not controlled, in fact majority of participants belonged to one religion. This may have been a result of selecting cases and controls from the same neighborhood. Religion may be a risk factor of Leptospirosis especially if it involves rituals or practices where members come in contact with contaminated rivers, water or soil.
Data collection was done through the use of semi-structured questionnaires and researcher observation. 1 While semi-structured questionnaires allow researchers to obtain substantial in ...
264 volume 123 number 3 March 2015 • Environmental Health .docxeugeniadean34240
264 volume 123 | number 3 | March 2015 • Environmental Health Perspectives
Research | Children’s Health A Section 508–conformant HTML version of this article is available at http://dx.doi.org/10.1289/ehp.1408133.
Introduction
Autism spectrum disorder (ASD) is a
developmental disorder with increasing
reported prevalence worldwide (French et al.
2013). Although genetics plays a strong role
in ASD, evidence suggests that environmental
exposures, particularly in utero or during early
life, also affect ASD risk (Grønborg et al.
2013; Hallmayer et al. 2011; Quaak et al.
2013). However, no specific environmental
toxicant has been consistently associated with
increased risk of ASD.
Air pollution contains various toxicants
that have been found to be associated with
neurotoxicity and adverse effects on the fetus
in utero (Crump et al. 1998; Grandjean and
Landrigan 2006; Rice and Barone 2000;
Rodier 1995; Stillerman et al. 2008). Airborne
particles are covered with various contami-
nants, and have been found to penetrate the
subcellular environment and induce oxidative
stress and mitochondrial damage in vitro (Li
et al. 2003; MohanKumar et al. 2008). In
rodents, these particles also have been found
to stimulate inflammatory cytokine release
systemically and in the brain, and alter the
neonatal immune system (Hertz-Picciotto
et al. 2005, 2008; MohanKumar et al.
2008)—processes that have been implicated
in ASD (Depino 2013; Napoli et al. 2013).
Several studies have explored associations
of air pollution with ASD, using the U.S.
Environmental Protection Agency (EPA)
hazardous air pollutant models, distance to
freeway, or local models for specific pollutants.
These studies suggest increased odds of having a
child with ASD with higher exposures to diesel
particulate matter (PM) (Roberts et al. 2013;
Windham et al. 2006), several metals (Roberts
et al. 2013; Windham et al. 2006), criteria
pollutants (Becerra et al. 2013; Volk et al.
2013), and some organic materials as well as
closer proximity to a freeway (Volk et al. 2011).
Our goal was to explore the association
between ASD and exposure to PM during
defined time periods before, during, and
after pregnancy, within the Nurses’ Health
Study II (NHS II), a large, well-defined
cohort with detailed residential history. This
nested case–control study includes partici-
pants from across the continental United
States, and exposure was linked to monthly
data on two size fractions of PM.
Methods
Participants. The study population included
offspring of participants in NHS II, a
prospective cohort of 116,430 U.S. female
nurses 25–43 years of age when recruited
in 1989, followed biennially (Solomon
et al. 1997). NHS II participants originally
were recruited from 14 states in all regions
of the continental United States, but they
now reside in all 50 states. The study was
approved by the Partners Health Care
Institutional Review Board and complied
with a.
HLTH 625Journal Article Reviews InstructionsReview and analyze.docxpooleavelina
HLTH 625
Journal Article Reviews Instructions
Review and analyze a recent journal article (published within the last 5 years) from a peer-reviewed publication (e.g The Journal of Infectious Diseases) about a TYPHOID FEVER.
· You must evaluate the chosen paper against at least 4 other peer-reviewed sources.
· You may cite your text; however, it does not count as one of your peer-reviewed sources.
· For each review, you will select an article about a topic from the required readings between each review assignment submission.
· You will then compose a 4 -page paper, not including the cover page and references, on your topic of choice.
· The goal of the assignment is to help link the current best practices identified in your text and the ongoing developments of research reflected in the peer-reviewed literature in support of learning outcomes A and B.
· You should, therefore, choose articles related to current epidemiologic trends for infectious diseases and/or the impact of the diseases and of the control measures on global populations. Special attention should be devoted to understanding the role of infectious agents as causes of morbidity and mortality in the context of economically developing nations.
Be sure to include the following elements:
· A clearly documented reference to best practices or standard of care
· Reported findings are completely and fairly assessed and critiqued
· A summary of the principal contents of the article under review
· Adequate information to understand the central themes and recommendations
· Paper, references, and citations all consistently follow current AMA formatting
Liberty University
Master of Public Health
Health 625
Prevention and Control of Infectious Diseases
STUDYING RISK FACTORS ASSOCIATED WITH HUMAN LEPTOSPIROSIS (Kamath R et al.):
AN ARTICLE REVIEW
IMA STUDENT
ID: XOXOXO
November 4, 2014
Words: 951
Article: Kamath R, Swain S, Nair SN, Pattanshetty S. Studying risk factors associated with human Leptospirosis. J Glob Infect Dis.2014; 6(1): 3–9. doi:10.4103/0974-777X.127941.
I. SUMMARY
The article presents the findings of a matched case-control study conducted to identify the occupational and environmental risk factors of Leptospirosis in India. The study was conducted from April 2012 to August 2012 with a total of 70 cases and 140 sex matched controls belonging to the same neighborhoods as cases.
Data collection on occupational and environmental risk factors was achieved through semi-structured questionnaires and researcher observation.
The study revealed that certain occupational and environmental factors were significantly associated with Leptospirosis and were therefore risk factors for this disease. Of all risk factors, the presence of a wound or cut in the skin while working was found to have the strongest association with Leptospirosis. This was followed by contact with soil contaminated with infected rodent urine. Occupations involving outdoor activities were significant ...
Identifying and Prioritizing Chemicals with Uncertain Burden oMalikPinckney86
Identifying and Prioritizing Chemicals with Uncertain Burden of Exposure:
Opportunities for Biomonitoring and Health-Related Research
Edo D. Pellizzari,1 Tracey J. Woodruff,2 Rebecca R. Boyles,3 Kurunthachalam Kannan,4 Paloma I. Beamer,5 Jessie P. Buckley,6
Aolin Wang,2 Yeyi Zhu,7,8 and Deborah H. Bennett9 (Environmental influences on Child Health Outcomes)
1Fellow Program, RTI International, Research Triangle Park, North Carolina, USA
2Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San
Francisco, San Francisco, California, USA
3Bioinformatics and Data Science, RTI International, Research Triangle Park, North Carolina, USA
4Wadsworth Center, New York State Department of Health, Albany, New York, USA
5Department of Community, Environment and Policy, Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, USA
6Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Heath, Johns Hopkins University,
Baltimore, Maryland, USA
7Northern California Division of Research, Kaiser Permanente, Oakland, California, USA
8Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA
9Department of Public Health Sciences, University of California, Davis, Davis, California, USA
BACKGROUND: The National Institutes of Health’s Environmental influences on Child Health Outcomes (ECHO) initiative aims to understand the
impact of environmental factors on childhood disease. Over 40,000 chemicals are approved for commercial use. The challenge is to prioritize chemi-
cals for biomonitoring that may present health risk concerns.
OBJECTIVES: Our aim was to prioritize chemicals that may elicit child health effects of interest to ECHO but that have not been biomonitored nation-
wide and to identify gaps needing additional research.
METHODS: We searched databases and the literature for chemicals in environmental media and in consumer products that were potentially toxic. We
selected chemicals that were not measured in the National Health and Nutrition Examination Survey. From over 700 chemicals, we chose 155 chemi-
cals and created eight chemical panels. For each chemical, we compiled biomonitoring and toxicity data, U.S. Environmental Protection Agency ex-
posure predictions, and annual production usage. We also applied predictive modeling to estimate toxicity. Using these data, we recommended
chemicals either for biomonitoring, to be deferred pending additional data, or as low priority for biomonitoring.
RESULTS: For the 155 chemicals, 97 were measured in food or water, 67 in air or house dust, and 52 in biospecimens. We found in vivo endocrine, de-
velopmental, reproductive, and neurotoxic effects for 61, 74, 47, and 32 chemicals, respectively. Eighty-six had data from high-throughput in vitro
assays. Positive results for endocrine, developmental, neurotoxicity, ...
This is basically a protocol upon the basis of P.G Public Health presentation on behalf of the Health effects due to environmental pollution on population.
2023 Undergraduate Research Symposium: Lane Belden and Bex Watson
The term folkhemmet or “the people’s home” is a Swedish political term that has enjoyed a wide usage amongst various political parties along with the development of the modern Swedish state over the past century. This project aims to define the term and describe its usage through the analysis of both primary and secondary sources.
The term is explored as a uniquely Swedish cultural phenomenon, with both populism and collectivism being explored as avenues to account for the seemingly contradictory usage of the term by opposing political parties. A timeline of the term is created to demonstrate its shifting associations.
2023 Undergraduate Research Symposium: Morgan Grougan
Amidst the ever-expanding cosmos of scientific literature, the quest for tools that can deftly extract and analyze data from publications has grown increasingly vital. Enter LoA (Librarian of Alexandria), a Linux-Python tool that harnesses the power of artificial intelligence to scour chemistry-related papers, meticulously extracting invaluable textual measurements and data into structured Excel files.
This approach engenders the formation of an expansive, high-quality dataset, poised to train predictive models in assessing the properties of chemicals, proteins, and other compounds, with a predominant emphasis on the field of chemistry. LoA's sophisticated AI algorithms artfully decipher and extract essential information from intricate scientific documents. Although the tool currently focuses on extracting text, plans for future iterations include deciphering images and delving into deeper analysis. LoA's potential transcends the realm of chemistry, with prospective applications in diverse scientific disciplines such as materials science, biology, and pharmacology, by tailoring the extraction process to the domain at hand.
Like the ancient Library of Alexandria, LoA aspires to become a beacon of knowledge, a comprehensive instrument for navigating the vast ocean of human intellect. As it is presented at an undergraduate research symposium, this innovative tool embodies the potential for revolutionizing scientific research, opening doors to interdisciplinary applications, and illuminating the path to discoveries yet unimagined. Embracing the beauty of imperfection, LoA continues to evolve, a testament to the resilience and adaptability that characterizes the boundless realm of scientific inquiry.
2023 Undergraduate Research Symposium: Carly Ghanem
The standard treatment for lower back pain has been interbody fusion: Transforaminal Lumbar Interbody Fusion (TLIF). The invasive nature leads to muscle detachment and damaged nerves. To address these issues, minimally invasive (MI) TLIF techniques have been developed.
While MI TLIFs show decreased blood loss and complication rates relative to open TLIF, surgery times and long-term outcomes are reported to be similar. Oblique lateral lumbar interbody fusion (OLLIF) is a MI lumbar spinal fusion through a single 10-15 mm incision, with a faster surgery time and easier approach. Anesthesia, surgery times, and blood loss were recorded for all patients that entered into the EMR. Because no suction is used in OLLIF procedures, blood loss was measured by weighing sponges and subtracting dry weight.
To monetize the cost per minute for a hospital, a published reference was utilized and adjusted with the consumer price index. These values were reported in aggregate and stratified, based on spinal level(s) of surgery. Mann-Whitney U-tests were utilized to test the null hypothesis that the OLLIF and TLIF groups have the same or identical mean distributions for age, BMI, blood loss, and uncensored time duration variables. Data analyses were performed using IBM SPSS. A shorter length of stay than TLIF by 58.5% across all surgeries studied was found.
The trend of shorter lengths of stay remained consistent when surgeries were stratified based on the spinal level(s) involved. OLLIF also had a lower surgical admission cost than TLIF, with a difference of $6,701 versus $11,583. These findings suggest that OLLIF may be a more cost-effective and efficient alternative to TLIF for treating lower back pain, particularly for hospitals with limited resources.
2023 Undergraduate Research Symposium: Kira Jonatzke
Under favorable environments, the worm C. elegans undergoes four different larval stages before becoming a fertile adult. However, when environments are harsh, such as under high temperatures or high population density and low food availability, C. elegans enters a different developmental program, known as dauer.
Dauers are developmentally arrested, highly resistant to stress and live long. Thus, when environments improve, dauers exit to the last larval stage and become fertile adults. Recently, we serendipitously discovered that the Mos1 transposon insertion site ttTi5605 produced more dauers at high temperatures, when compared to wild-type animals. This Mos1 insertion site is situated between two genes, the predicted glucose transporter FGT-2 and the F14E5.8 gene of unknown function.
Thus, the Mos1 transposon insertion might alter the expression of FGT-2 and/or F14E5.8, which potentially suggests a role for at least one of these proteins in regulating the switch to the dauer program.
2023 Undergraduate Research Symposium: Lexi Soltesz
A central health issue for those with a chronic spinal cord injury (SCI) above the sixth thoracic vertebrae is autonomic dysfunction. Autonomic dysfunction results in significant increases and decreases in blood pressure and negatively affects health-related quality of life.
This uncontrolled blood pressure also negatively impacts cognitive function and adherence to rehabilitation programs. Additionally, the lesion itself impairs motor function thereby resulting in decreased physical activity and impaired mitochondrial function. Moreover, autonomic dysfunction can lead to an increased risk of stroke, and therefore increased mortality. Mild intermittent hypoxia (MIH), an experimental protocol in which participants experience lower oxygen, in a controlled and repetitive sequence, has been shown to improve blood pressure control in humans.
Our study aims to investigate the impact of MIH on autonomic dysfunction during in-lab provocation and during in-home testing. Likewise, we will also investigate the impact of MIH on mitochondrial and microvascular function and motor function. Our preliminary data shows that MIH may improve autonomic dysfunction which may be explained by improvements in baroreceptor and/or mitochondrial and endothelial function. As evidenced by our preliminary data, MIH is a promising potential protocol for improving health-related quality of life in those with SCI.
2023 Undergraduate Research Symposium: Mahmoud Teran
The development of memories, including those throughout extinction learning, require neuroplasticity for encoding and retrieval to occur. As environmental factors can affect gene expression, epigenetic changes can play a critical role in the development of memory formation and updating and ultimately manifesting in behavioral changes reflective of the learning.
The purpose of the current project is to show the utility of Positron Emission Tomography (PET), a functional, molecular imaging technique that employs radioactive substances to measure specific markers in the brain. As part of our efforts to understand the neurobiological mechanisms of fear learning and the role of epigenetic changes using PET, images of the brains were collected before and after extinction learning of acquired long-term fear (LTF) memories induced by shock tone pairings made every 30 seconds over 38 min.
PET images were collected by injecting the radiotracer [18F]TFAHA, a substrate for class IIa histone deacetylases (HDACs). The resulting accumulation of the breakdown product of [18F]TFAHA could be considered as a proxy for class IIa HDAC expression changes before and after LTF memory. HDAC activity is directly related to gene expression changes through deacetylation of histone lysine residues. This results in a closed chromatin conformation and prevents the binding of RNA polymerase II and ultimate gene transcription and protein synthesis.
This can then be manifested and seen as behavioral change. Our preliminary analysis of PET images results indicate a significant interaction effect between pre-to-post class IIa HDAC expression-activity, sex, and shock condition. Additional PET image analysis is anticipated to show the extent of HDAC activity in both the sexes following LTF.
2022 Undergraduate Research Symposium: Christina Kort
There are five developmental factors discussed throughout the review that are applicable to adolescents during the pandemic. This involves the incorporation of nutrition and exercise health, in which a lack of physical activity or appropriate eating habits may be hindering growth.
Learning experiences have been altered to a digital platform and have deeply affected students' motivation and cognitive engagement. Forming strong social connections with friends and members of the community is another way to help ensure that developing brains are progressing. In some cases, the home environment may be negatively impacting the ability to complete work or achieve personal space. Taking some time away or setting boundaries around family may be crucial for growth.
The last aspect necessary for adolescents to sustain positive development consists of a daily structure. Staying active in recreational activities is a good way to ensure structure and can greatly benefit the other factors related to forming new bonds and getting physical exercise.
2022 Undergraduate Research Symposium: Mary Tooma
Graduate co-author: Emily Graham LeRose
This research was conducted to investigate the underlying etiological cause(s) and/or psychosocial contributions to suicidal ideation as highly self-reported among individuals with a developmental stutter.
A comprehensive literature review was completed to explore two of the hypothesized components thought to increase risk for suicidal ideation in this population; genetic heritability of suicidal ideation and the presence of co-morbid mental health disorders arising as a result of having a stutter (i.e., depression, anxiety, etc.). Additionally, an empirical review was completed for recommendations to improve overall outcomes in therapy for individuals who stutter.
Results from this investigation of the literature found the most empirical support for a connection between high rates of co-morbid mental health disorders and suicidal ideation in individuals who stutter. Additionally, a therapeutic approach titled "Attachment-Based Family Therapy" has been shown to be highly effective in treating individuals, particularly adolescents, who experience suicidal ideation and depression.
2022 Undergraduate Research Symposium: Justin Ahrens
Graduate co-author: Maddy Denison
The main goal of this project is to use IrIII complexes to monitor cytochrome P450 (CYP) activity. CYP P450 metabolism determines how quickly drugs are excreted from the body and what kind of dose is required for pharmaceuticals to be effective.
Existing probes for CYPs are non-fluorescent, but when CYPs metabolize them, they are “turned on” and fluoresce. Even though these probes are able to monitor metabolism, once they are metabolized and “turned on” they cannot be reversed or turned off. Therefore, this is no current way to monitor dynamic changes in CYP activity continuously over time.
The Kodanko laboratory is addressing this unmet need by developing IrIII complexes that are reversible sensors of CYP enzymes. A chiral resolution strategy with enantioenriched ligands was used to prepare four analogs of IrIII complexes with different stereochemistry. These complexes were evaluated as emissive sensors in human liver hepatocytes to establish which IrIII complex is the lead compound for sensing CYP in living cells. Results from this multi-disciplinary study will be reported.
2022 Undergraduate Research Symposium: Bahea Nasser
My research is overall in the issue of the mass incarceration rate of people with serious mental illness. My research goes into detail about the factors and causes of this problem, re-offending, deinstitutionalization, other important information, and how people with serious mental illness in the criminal justice system receive inadequate treatment.
2022 Undergraduate Research Symposium: Tareq Murshed
Accounting has had major developments and throughout the years it has went from pen and paper to paperless.
2022 Undergraduate Research Symposium: Hanna Alfasih
This research is about the misuse of analgesics and how they have contributed to the opioid epidemic.
2022 Undergraduate Research Symposium: Dorian Mersinllari
This PowerPoint shows how can CRNAs better help/ understand their patients? It was a project for my English class and I think it's really good at explaining how nurses should be treating their patients and how it would help their relationship with them. It's a 13-slide PowerPoint that includes a synthesis map and six good sources. I also had to record myself presenting it which includes information outside of what you see on the PowerPoint.
2022 Undergraduate Research Symposium: Ma'ldah Sheikh
The male gaze is a point of view in literary and digital media. It is from the viewing pleasure and perspective of heterosexual men. This form of content is predominantly characterized by the objectification and sexualization of women and other minority groups. The female gaze is meant to oppose the male gaze in cinema, but there are many controversies pertaining to this within the film discourse community.
Many theorists debate that there is no such thing as the female gaze, while others argue that even with the existence of the female gaze, the male gaze can never truly be reversed.
2022 Undergraduate Research Symposium: Vivian Truong
Young adults (18-25) have the highest prevalence (29.4%) of any mental illness and the lowest rate of receiving mental health services (38.9%; NIMH). WSU CAPS provides Wayne State students with an online mental health screening opportunity. The numbers of screenings were of interest for this project.
COVID-19 has been shown to negatively impact students’ social and academic engagement, as a result, screening usage during the pandemic was expected to increase. Additionally, the literature on gender and racial/ethnic disparities in mental health service utilization suggest that screening tools may be used less by men and underrepresented minorities. We also expected gender and racial disparities in use, despite the anonymity provided by online screening.
We examined screening use during the pandemic from 3/15/2020 to 6/15/2021 in comparison with pre-pandemic use from 3/15/2018 to 6/15/2019. It is found that the rate of screening is slightly elevated during the pandemic. Secondly, the rate of screening use among different demographic groups, specifically racial/ethnic groups, and gender groups during the fall of 2020 was explored. Of the 897 screenings that were completed, White completed more than 50% of them. Black students were less likely to be screened (12.2% versus 14.8%, p < .01), as were Hispanic students (3.3% versus 5%, p < .001).
Surprisingly, Asian students were more likely to complete the screening (16% versus 10.2%, p < .001). Students who identified as male were highly underrepresented among those who completed the screenings (17.5% versus 40.7% of students).
2022 Undergraduate Research Symposium: Shane Tinsley
Introduction: Disease-specific health awareness (HA) campaigns have rapidly developed as an important avenue to improve patient education and ideally outcomes. Our study objective was to understand the impact of urological HA months on engaging public search interests in the United States.
Methods: We utilized Google Trends to examine public health interest in urologic conditions during monthly awareness campaigns over a 17-year period (2004-2021). Relative Search Volume (RSV) during the annual HA campaign months relative to non-health awareness (NHA) campaign months was calculated. Differences between HA-RSV and NHA-RSV months were compared using t-test.
Results: Although small increases in public interest were noted for certain diseases (prostate cancer in November, testicular cancer in April and erectile dysfunction), there was interestingly a comparative decrease in RSV for other diseases (bladder cancer, prostate cancer in September, testicular cancer in November, kidney cancer, benign prostate hyperplasia and male infertility) in their respective HA months; however, none of these differences were statistically significant (p > 0.05).
Conclusion: Our study did not find a significant difference in public interest of any urological diseases during their respective HA campaign months. This highlights the critical need for further research to investigate potential improvements in campaign methodology during dedicated HA months to better achieve their goals of increased public health engagement.
2022 Undergraduate Research Symposium: Avery Bacheller
My research abstract explains the importance of adolescent suicide by breaking down statistics, defining the discourse community, citing and explaining sources that help build a good argument for my thesis. All of these combined help me to spread awareness and information regarding adolescent suicide.
2022 Undergraduate Research Symposium: Taha Kader
Family physicians are crucial to providing appropriate medical care in rural areas. Family physicians tackle various roles such as maternity and emergency care in these areas. However, there aren't nearly enough family physicians in these areas, and something needs to be done.
2022 Undergraduate Research Symposium: Samaah Saifullah
Graduate co-author: Kelsey L. Canada
Automated hippocampal subfield segmentation methods have led to exponential growth in the literature. Although automated segmentation is perfectly reliable, deviations from anatomical definitions are common and weaken their validity.
To address the lack of guidance for quality control (QC) of automated segmentation methods, we developed a taxonomy of errors and two-step protocol for 1) identification and 2) manual correction. Raters examined segmentations from a customized atlas to identify errors in six categories with severity ratings; only major severity errors are manually corrected in order to minimize introducing human error.
The QC procedure was developed and cross-validated with an independent sample on two MRI scanners. Raters had excellent agreement in QC decisions between- and within-raters on all regions, manual corrections introduced less than 3% error and were unrelated to participant demographic.
The feasible and reliable QC procedure allows confident interpretation of hippocampal subfield segmentations, and potential applications to other brain regions.
2022 Undergraduate Research Symposium: Neel Patel and Mariana Sierra
The Kristen Rat Sarcoma (KRAS) protein, encoded by the KRAS gene, is a signal transducer that plays a crucial role in regulating cell proliferation. KRAS mutations have been known to cause lung, colorectal, and pancreatic cancers. Previously, KRAS was considered an “undruggable” target. However, with better understanding of the protein’s biology paired with advanced new technologies, the FDA approved the first KRAS inhibitor (sotorasib) for lung cancer patients with the KRASG12C mutation in 2021, expressing the recent interest of targeted drugs for KRAS.
In clinical trials, sotorasib proved ineffective for pancreatic and colorectal cancers with the G12C mutation. Irrespective of mutant identity, oncogenic KRAS requires activation by the guanine nucleotide exchange factor (GEF) Son of Sevenless 1 (SOS1), highlighting an exploitable vulnerability with broad therapeutic applicability. The goal of this study is to develop novel pan-KRAS inhibitors by targeting the KRAS-SOS1 interactions through computational modeling. To start, we applied Gaussian accelerated molecular dynamics (GaMD) simulation, an advanced conformational sampling method, to collect the nature of the KRAS protein motion in solution. Then, the clustering analysis method was used to assemble KRAS conformational structures into ten groups for later virtual screening and docking simulations.
We aim to address 20 to 30 compounds to later be experimentally assessed for their (1) ability to disrupt the KRAS-SOS1 interactions and (2) cytotoxicity in KRAS mutation-bearing cell lines. The work will provide insights in the drug efficacy of KRAS inhibitors and give rise to a novel set of KRAS candidates to be used in clinical oncogenic treatments.
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Wayne County PM2.5 Levels on Lab Visit Days Among Youth With Asthma: A Methodological Approach
1. Wayne County PM2.5 Levels on Lab Visit Days
among Youth with Asthma:
A Methodological Approach
Taral Patel1*, Sophie Habashy1*
Jacqueline Rodriguez-Stanley1, MA
Samuele Zilioli1,2, PhD
*Denotes equally contributing first authors
1Department of Psychology,
2Department of Family Medicine and Public Health Sciences, Wayne State University
2. Asthma negatively affects the quality of life of those who suffer from it, with the
acknowledgement that the African American/Black community is
disproportionately afflicted by the disease. Research suggests that increased
atmospheric particulate matter among other pollutants is correlated with higher
rates of reported asthma symptoms and hospitalizations. The present study
describes the methodology of cross-referencing Environmental Protection Agency
(EPA) reported daily particulate matter 2.5 (PM2.5) with participant laboratory
visits with the goal of allowing researchers to assess the effect of this pollutant
with concurrent reports of psychosocial and asthma measures. Part of this data
come from the Asthma in the Lives of Families today study which investigated
psychosocial predictors of asthma-related health among African American children
from the Detroit area between 2011-2018. Determining PM2.5 levels on lab visit
days was conducted in multiple steps. Firstly, participants’ zip codes were used to
determine their geographical census block (i.e., GEOID). Next, GEOIDs were
matched to the most closely located EPA PM2.5 sites of the twelve stationed in
Wayne County. After the EPA site was matched to the participant, the PM2.5
measurement on the day of each participant’s ALOFT visit was identified. This
methodological approach provided a clear air pollution reference on the date of lab
visits, allowing ALOFT researchers to investigate its specific and subsequent
impact on child asthma health.
Abstract
3. Background
▪ Air pollutants such as particulate matter 10 (PM10), particulate matter 2.5, (PM2.5) and ozone
can exacerbate asthma symptoms (Ostro et. al., 2001; Huang et al., 2021)
▪ Harsher weather conditions, greater precipitation, higher pollen, and changes
in vegetation attributed to seasonal peaks and harsher climates, are associated with greater
asthma aggression (D'Amato & Cecci, 2008)
▪ Detroit has comparatively higher rates of PM2.5 relative to expected amounts in other urban
areas (Milando et al., 2016).
▪ Understanding environmental contaminants is especially important for the African American
population who are disproportionally affected by asthma-related morbidity (Huang et al.,
2021)
▪ This study focuses on PM2.5 recorded from the Environmental Protection Agency (EPA)
monitoring sites in Wayne County (EPA, 2018).
▪ Connecting one's physical environment with their psychosocial processes are important to
predict asthma symptomology.
Introduction
4. Research Aim
▪ Connect government pollutant data with the date youth with asthma participated in a
research study.
Introduction
Supplemental Hypotheses
▪ There will be higher PM2.5 in peak seasons
compared to when seasons are not in peak
▪ Higher PM2.5 will be associated with greater
asthma exacerbation measured by lower
peak flow values and higher self-reported
quantity and severity of asthma symptoms
5. Participants & Procedure
Demographic Distribution
• N = 144; 45.8% female
• M = 12.72, σ = 1.66, age range 10 - 17
• 93.1% Black/African American
ALOFT Study Overview (2011-2018)
• Multi-wave study on 297 families that examined
psychosocial and biological factors on asthma
• Consisted of lab 1 visit, 4-day daily assessment
period, and a final at-home visit 1 week later
Methodology
6. Measures
Peak Flow
• Measures lung capacity and function operationalized as peak expiratory flow rate (PEFR)
• Measured 3 times before bed each night.
• Best nightly reading used for analyses.
• *M = 306.93 L/min, σ = 82.76 L/min; range = 115 -575 L/min
Asthma Symptom Frequency
• Number of symptoms experienced each night
• *M = 10.29, σ = 10.53; range = 0.00 - 45.00
Asthma Symptom Severity
• Self-reported severity/ intensity of wheezing, chest tightness, shortness of breath, coughing
• Scale: 0 (none), 4 (severe)
• *M = 1.33, σ = 0.39; range = 1.00 - 2.60
*Note: All values were calculated as an average across the 4-day at-home daily assessment period
Methodology
7. Measures (cont.)
Seasons
• Date of lab visit was used to code each
participant as visiting during season peak (1)
or non-peak (0)
• Peak Seasons
• Winter: Mid- January through February
• Summer: July through mid-August
• Spring: Mid-April through May
• Fall: October through mid-November
• Non-Peak Seasons
• Remaining months
Covariates
• Height, sex, age, race, medication use,
smoking
Methodology
8. Methodological Approach
1. EPA air pollutant monitoring site’s latitude & longitude
used to identify Wayne County zip-code
2. Cross-referenced zip-codes of participants and EPA
monitoring sites and assigned an EPA monitoring site to
each participant (see Wayne County PM2.5 Map)
3. PM2.5 values spreadsheet was downloaded from EPA for
each year of study (2011- 2028)
4. The PM2.5 value on the day of the participant's Lab 1
visit was recorded (Note: If this value was unavailable, the
value on the closest date before Lab 1 visit was used)
5. This methodological approach was repeated for all
participants
Results
9. Wayne County PM2.5 Map
Results
The resulting Wayne
County map depicts the
locations of the various EPA
PM2.5 monitoring sites used
to collect data from to
match with the participants
within the same or adjacent
zip-codes
10. Supplemental Results
Results
Table 1. Mean Difference of PM2.5 between Season’s Peaks
Table 2. PM2.5 predicting Asthma Outcomes
Although not statistically significant,
there is an evident increase in PM2.5
during peak seasons
PM2.5 was not associated with peak
flow values, asthma symptom
frequency, or asthma symptom severity
11. Discussion
Significance
• The constructed methodology of pin-pointing the residence of participants and
collecting data from the near monitoring site is a process that can be repeated for future
studies and methodologies
Limitations
• The PM2.5 values taken from publicly available EPA data had inconsistencies in
documentation
• Limited availability of PM10 & ozone data, preventing options to study other pollutants
• Small sample size contained within one county among one demographic
(Black/African American youth)
• Considering PM2.5 estimates over longer periods of time (i.e., 6 months) may be a
more accurate exposure composite
Future Directions
• Investigate the time in between air pollutant exposure and occurrence of asthma
symptom exacerbation
• Determine the psychosocial factors that may buffer air pollutants impact on asthma
symptoms
• Further investigation of association between peak seasons and asthma outcomes
12. Acknowledgements
We would like to extend our many thanks and acknowledgements to Jacqueline
Rodriguez-Stanley, MA and Dr. Samuele Zilioli, PhD for their time, guidance,
mentorship, and assistance throughout our research process and for their support
as we pieced this project together.
We would also like to thank the entire ALOFT team for supplying us with the
data used in this project.
We could not have accomplished this without the work of many dedicated
researchers that worked to collect this data.
Contacts
Taral Patel: taralpatel@wayne.edu
Sophie Habashy: sophiehabashy@wayne.edu
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